MEAN WEIGHT LOSS POST-ENDOSCOPIC SLEEVE GASTROPLASTY IS INDEPENDENT OF THE SUTURE PATTERN: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL

Aims We compared the efficacy of three different suturing patterns in terms of weight loss after endoscopic sleeve gastroplastly.

Methods: Prospective, single blind, single centre randomized controlled trial. Patients were randomly assigned to one of the three study groups plus lifestyle interventions. In group A, the suture pattern aimed to modify gastric accommodation by increasing the distention ability of the fundus, in group B to reduce the gastric volume and in group C to assume an interruption of the normal gastric emptying. Inclusion criteria: 18-64 years and BMI 30-40 kg/m². The difference in the mean percentage of weight loss [total body weight loss (TBWL) and excessive weight loss (EWL)] among the three groups at 12 months of follow-up consisted the primary outcome.

Results Overall, 48 patients (83.3% female, age 41.9 years, BMI:33.8±2.7 kg/m²⁾ were assigned to the three groups (16 in each group). In the entire cohort the mean (95%CI) TBWL and EWL at the end of the follow-up were 10.11%(7.1-13.12) and 42.56%(28.23-56.9). Regarding the primary endpoint there was no difference among the three study groups in terms of mean TBWL [9.13%(2.16-16.11) vs. 11.29%(5.79-16.80) vs. 9.96%(4.58-15.35); p=0.589] and mean EWL [34.54%(6.09-62.99) vs. 44.75%(23.63-65.88) vs. 46.94%(16.72-77.15); p=0.888] at 12 months post-procedure. Moreover, the three groups did not differ neither in terms of mean gastric emptying time nor in terms of satiety tests at the end of the follow-up.

Conclusions Different suture patterns during endoscopic sleeve gastroplasty demonstrated comparable efficacy in terms of weight loss with all of them achieving≥25% EWL at 12 months.

Publication History

Article published online:
14 April 2022