Endoscopy 2022; 54(S 01): S122
DOI: 10.1055/s-0042-1744877
Abstracts | ESGE Days 2022
ESGE Days 2022 Digital poster exhibition

THE DUBLIN SCORE IS A USEFUL TOOL FOR PREDICTING DISEASE COURSE IN PATIENTS WITH ULCERATIVE COLITIS

J. Doherty
1   School of Medicine, University College Dublin, Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland
2   www.initiativeibd.ie, INITIative IBD research network, Dublin, Ireland
,
N.O Morain
1   School of Medicine, University College Dublin, Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland
,
R. Stack
1   School of Medicine, University College Dublin, Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland
,
F.O Hara
3   Trinity College, Department of Gastroenterology, Tallaght University Hospital, Dublin, Ireland
,
R. Corcoran
4   Trinity College, Department of Gastroenterology, St James Hospital, Dublin, Ireland
,
Y. Bailey
4   Trinity College, Department of Gastroenterology, St James Hospital, Dublin, Ireland
,
D. McNamara
3   Trinity College, Department of Gastroenterology, Tallaght University Hospital, Dublin, Ireland
5   Trinity College, Trinity Academic Gastroenterology Group, School of Medicine, Dublin, Ireland
2   www.initiativeibd.ie, INITIative IBD research network, Dublin, Ireland
,
D. Kevans
5   Trinity College, Trinity Academic Gastroenterology Group, School of Medicine, Dublin, Ireland
4   Trinity College, Department of Gastroenterology, St James Hospital, Dublin, Ireland
2   www.initiativeibd.ie, INITIative IBD research network, Dublin, Ireland
,
G. Doherty
1   School of Medicine, University College Dublin, Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland
2   www.initiativeibd.ie, INITIative IBD research network, Dublin, Ireland
› Author Affiliations
 

Aims The DUBLIN (Degree of Ulcerative colitis Burden of Luminal Inflammation) is a novel simple clinical score of inflammation in patients with Ulcerative Colitis (UC).

Methods We performed a multicentre study. DS at diagnosis was calculated based on disease extent and endoscopic severity in patients with UC. Study outcomes were need for colectomy and/or biologic therapy and time to commencing biologics dependent on DS at diagnosis. We examined prospectively the association between DS at recruitment and FCP, albumin and C-reactive protein.

Results 268 patients had a DS at diagnosis. Baseline demographics are summarised in [Table 1]. Median DS was significantly higher in patients requiring a colectomy compared to those colectomy free (5 versus 4, p=0.005) and in patients requiring biologic therapy compared to patients not requiring biologic agents (4 versus 3, p=0.02) ([Figure 1a,b]). Of patients requiring biologic 28% with a DS≤3 required biologic therapy compared to 64% of patients with a DS>3. Median time to commencing biologic therapy was significantly shorter in patient with a DS>3 than those with a DS≤3 (2.8 versus 7.1 years, p=<.001). There was a weak positive correlation between both DS and faecal calprotectin [correlation coefficient 0.27, p=0.001] and C-reactive protein [correlation coefficient 0.1, p=0.03] and a weak negative correlation between DS and albumin [correlation coefficient -0.32, p=<0.001].

Zoom Image
Fig. 1

Table 1

Baseline Demographics

N=268

Median age at diagnosis (IQR)

38.9 (27 – 50)

Biologic therapy

Male

138 (

Colectomies

5ASA

Median DUBLIN SCORE at diagnosis (IQR)

Immunomodulator

Median DUBLIN Score at recruitment (range)

Conclusions Our study validates the clinical utility of the DS at diagnosis in predicting a patients disease course including need for biologics and surgery.



Publication History

Article published online:
14 April 2022

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