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DOI: 10.1055/s-0042-1744877
THE DUBLIN SCORE IS A USEFUL TOOL FOR PREDICTING DISEASE COURSE IN PATIENTS WITH ULCERATIVE COLITIS
Aims The DUBLIN (Degree of Ulcerative colitis Burden of Luminal Inflammation) is a novel simple clinical score of inflammation in patients with Ulcerative Colitis (UC).
Methods We performed a multicentre study. DS at diagnosis was calculated based on disease extent and endoscopic severity in patients with UC. Study outcomes were need for colectomy and/or biologic therapy and time to commencing biologics dependent on DS at diagnosis. We examined prospectively the association between DS at recruitment and FCP, albumin and C-reactive protein.
Results 268 patients had a DS at diagnosis. Baseline demographics are summarised in [Table 1]. Median DS was significantly higher in patients requiring a colectomy compared to those colectomy free (5 versus 4, p=0.005) and in patients requiring biologic therapy compared to patients not requiring biologic agents (4 versus 3, p=0.02) ([Figure 1a,b]). Of patients requiring biologic 28% with a DS≤3 required biologic therapy compared to 64% of patients with a DS>3. Median time to commencing biologic therapy was significantly shorter in patient with a DS>3 than those with a DS≤3 (2.8 versus 7.1 years, p=<.001). There was a weak positive correlation between both DS and faecal calprotectin [correlation coefficient 0.27, p=0.001] and C-reactive protein [correlation coefficient 0.1, p=0.03] and a weak negative correlation between DS and albumin [correlation coefficient -0.32, p=<0.001].
Baseline Demographics |
N=268 |
||
---|---|---|---|
Median age at diagnosis (IQR) |
38.9 (27 – 50) |
Biologic therapy |
|
Male |
138 ( |
Colectomies |
|
5ASA |
Median DUBLIN SCORE at diagnosis (IQR) |
||
Immunomodulator |
Median DUBLIN Score at recruitment (range) |
Conclusions Our study validates the clinical utility of the DS at diagnosis in predicting a patients disease course including need for biologics and surgery.
Publication History
Article published online:
14 April 2022
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