INCIDENCE OF EARLY ONSET COLORECTAL CANCER AND ADVANCED NEOPLASIA DOES NOT HAVE MALE PREDOMINANCE – RETROSPECTIVE OBSERVATIONAL STUDY

Aims To assess the real-life incidence of early onset colorectal cancer and advanced neoplasias in a single non-university endoscopic center.

Methods We retrospectively assessed the incidence of advanced neoplasias and colorectal cancer in population under 50 years of age compared to older population. We collected the data from all colonoscopic examinations performed in non-university hospital from January 2012 to the end of June 2021.

Results In study period, 18257 colonoscopic examinations were done in total, 14728 in population 50 years and older and 3529 in population under 50 years of age. In our study there were 29 patients with early onset colorectal cancer (5.12% from 557 total) and 106 patients with early onset advanced neoplasias (4.47% from 2371 total). The incidence of early onset colorectal cancer and advanced neoplasias in younger group did not significantly differ between the sexes (see [Table 1]). Positive family history of colorectal cancer was not significantly associated with risk of early onset colorectal cancer (p=0.316) or early onset advanced neoplasia (p=0.323) in our study.

Table 1

	All	Men	Women	p
Colorectal cancer≥50	528/14728 (3.59%)	331/7942 (4.17%)	197/6786 (2.09%)	<0.001
Advanced neoplasias≥50	2265/14728 (15.38%)	1477/7942 (18.60%)	788/6786 (11.61%)	<0.001
Colorectal cancer<50	29/3529 (0.82%)	14/1772 (0.79%)	15/1757 (0.85%)	0.834
Advanced neoplasias<50	106/3529 (3.00%)	58/1772 (3.27%)	48/1757 (2.73%)	0.361

Conclusions Early onset colorectal cancer represented 5.21% of all colorectal cancers diagnosed in the study period. The incidence of colorectal cancer and advanced neoplasias in population under 50 years of age was 0.82% and 3.00% compared to 3.59% and 15.38% in older population. In contrast to older population, the incidence of early onset colorectal cancer and advanced neoplasias did not differ between the sexes. Positive family history of colorectal cancer was not significantly associated with risk of early onset colorectal cancer or advanced neoplasias.

Publication History

Article published online:
14 April 2022