IMPACT OF A LOW-RESIDUE DIET (LRD) ON BOWEL CLEANSING QUALITY (BCQ) BEFOR COLONOSCOPY: A PROSPECTIVE SINGLE BLINDED RANDOMIZED CONTROLLED TRIAL

Aims The optimal LRD duration is still controversial. We have compared the effect of different LRDregimens in a Mediterranean diet population on the quality of bowel preparation and patient tolerance.

Methods Consecutive patients scheduled for outpatient colonoscopy were randomized to the 1-day, 3-days, 5-days or without LRD(control group) groups. All patients received PEG-ES for bowel preparation(BP). The primary outcome was BCQ as evaluated using the Boston Bowel Preparation Scale(BBPS). Secondary outcomes were polyp/adenoma detection, rate adherence to and level of satisfaction with theLRD, difficulty following the dietary recommendations, and willingness to repeat the sameLRD in the future.

Results 400 patients(100 per group) were included. There was a significant difference in BP quality between 3-daysLRD and 5-daysLRD vs1-dayLRD and control group. The 5-daysLRD group had a BBPS of 7.38±1.43 points, 3-daysLRD ; 6.87±1.81, while the 1-dayLRD group had a score of 5.12±1.36, control group; 5.08±1,26(P<0.001).There was no significant difference between 3-days vs 5-daysLRD or 1-dayLRD vs control group.

The groups reported similar polyp/adenoma detection rates and patient tolerance scores. The numbers of patients who reported that compliance as easy were 83(83%) in the 3-days group vs 58(58%) in the 5 days group (p<0.05) and the numbers who were willing to use the diet again were 91(91%)vs 61(61%);(p<0.05).

Conclusions 5-daysLRD did not offer advantages over 3-daysLRD in preparation for colonoscopy. Patients in the 3-day group had higher tolerance and satisfaction levels than patients in the 5-dayLRD group. However, BPquality was higher with the 3-days group than with the 1-dayLRD or control group

Publication History

Article published online:
14 April 2022