EVALUATION OF 2 DIFFERENT REGIMENS OF COLON PREPARATION FOR AN ADVANCED CLEANING USING A 2LT PEG-CS WITH SIMETHICONE: A RANDOMIZED, CONTROLLED STUDY – THE ERACLES STUDY

Aims Although the split dose regimen is recommended as bowel preparation in patients underwent to morning colonoscopy, its use in daily practice remains limited. Conversely, the classic day before regimen account for up to 35% of inadeguate bowel cleansing.

On this context, the Italian Society of Digestive Endoscopy(SIED) promoted a prospective muticentric randomised study to compare two different regimen of low volume(PEG/citrate/symeticone) bowel preparation in patient that undergo to early morning colonoscopy

Methods In this ad-interim analysis, 204 patient were equally randomised in group A to assume both dose of preparation from 8pm to midnight(the day before late group) and group B in which the second dose was taken 4 hours before the examination(split dose group). The primary endpoint was to evaluate bowel cleansing adopting Boston Bowel Preparation Score. Secondary endpoints were the evaluation of compliance and tolerability, safety, Intraluminal boubles score, polyp detection rate.

Results Efficacy measured using Chi-square test showed 83,9%(CI 95%, 74,5-90,9) good or optimal bowel cleansing for patients in group A and 94,3%(CI 95% 87,1-98,1) in group B (p-value0,029)

Thirteen patient in the group A and 20 in the group B referred fear of incontinence during the journey to the hospital (p value=0.165).

Compliance, tolerability, propensity to repeat the same regime in the next colonoscopy, didn’t show differences among the two groups.

Conclusions Although the split dose regimen remains the standard, in some specific setting, the use of the day before late represents an alternative that guarantees an adeguate intestinal cleansing for early morning colonoscopy

Publication History

Article published online:
14 April 2022