Endoscopy 2022; 54(S 01): S185
DOI: 10.1055/s-0042-1745065
Abstracts | ESGE Days 2022
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THE EFFECTIVENESS AND TOLERABILITY OF VERY LOW VOLUME PREPARATION FOR COLONOSCOPY COMPARED TO STANDARD 2 L AND 4 L PEG-SOLUTIONS IN A REAL-LIFE SETTING

N. Nyhlin
1   Örebro University Hospital, Division of Gastroenterology, Department of Medicine, Örebro, Sweden
,
O. Bednarska
2   Linköping University Hospital, Department of Gastroenterology, Linköping, Sweden
,
P. Thelin Schmidt
3   Karolinska Institutet, Department of Medicine, Solna, Stockholm, Sweden
4   Ersta Hospital, Department of Medicine, Stockholm, Sweden
,
G. Wurm Johansson
5   Skåne University Hospital, Lund University, Department of Gastroenterology, Malmö, Sweden
,
E. Toth
5   Skåne University Hospital, Lund University, Department of Gastroenterology, Malmö, Sweden
,
P. Lindfors
6   Karolinska Institutet, Department of Clinical Neuroscience, Division of Psychology, Stockholm, Sweden
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Aims Adequate bowel cleansing is essential for a high-quality colonoscopy. Recently, a new 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to standard 2L PEG-ASC and 4L PEG solutions, in a real-life setting.

Methods In six different endoscopy units in Sweden, all outpatients undergoing colonoscopy were either prescribed 2L PEG-ASC or 4L PEG-solutions according to local routines, or the 1L PEG-ASC, all in split dose regimen. Bowel cleansing effectiveness and patient experience was assessed using the Boston Bowel preparation scale (BBPS) and a patient questionnaire.

Results A total of 1098 patients were included in the study. Mean age was 58 years, 48% men and 52% women. Cecal intubation rate was 96% for the 4L solutions, 90% for 2L PEG-ASC and 94% for 1L PEG-ASC. Nausea and vomiting were more common with 1L PEG-ASC compared to 2L PEG-ASC and 4L PEG (43%, 22%, 37% and 12%, 4% and 7% respectively). Smell, taste and total experience was graded as better for 1L PEG-ASC compared to the 4L PEG solutions (p<0.001), and similar compared to the 2L PEG-ASC solution.

BBPS scores are presented in the table:

Table 1

BBPS

4L PEG (n 371)

2L PEG-ASC (n 204)

1L PEG-ASC (n 523)

p-value (ANOVA, Tukey HSD)

Right Colon(mean, SD)

2.55 (0.55)

2.39 (0.71)

2.73 (0.54)

<0.001 (1l vs 4L)
<0.001 (1L vs 2L)

Transverse colon(mean, SD)

2.69 (0.49)

2.47 (0.65)

2.79 (0.50)

<0.05 (1L vs 4L)
<0.001 (1L vs 2L)

Left colon(mean, SD)

2.64 (0.51)

2.48 (0.65)

2.75 (0.54)

<0.05 (1L vs 4L)
<0.001 (1L vs 2L)

Total score(mean, SD)

7.86 (1.43)

7.28 (1.97)

8.25 (1.53)

<0.001 (1L vs 4L)
<0.001 (1L vs 2L)

Conclusions 1L PEG-ASC leads to better total BBPS scores and subsegment scores compared to 2L PEG-ASC and 4L PEG products. Nausea and vomiting were more common, but patient satisfaction was as good as or better than the other products.



Publication History

Article published online:
14 April 2022

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