Endoscopy 2022; 54(S 01): S249
DOI: 10.1055/s-0042-1745285
Abstracts | ESGE Days 2022
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PANCREATIC CYSTIC FLUID GLUCOSE LEVEL IN THE DIAGNOSIS OF MUCINOUS PANCREATIC CYSTS: A SINGLE CENTRE EXPERIENCE

S. Stigliano
1   Campus Bio-Medico University Hospital, Endoscopy Department, Rome, Italy
,
F.M. Di Matteo
1   Campus Bio-Medico University Hospital, Endoscopy Department, Rome, Italy
› Author Affiliations
 

Aims Available intra-cystic biomarkers have low accuracy in distinguishing pancreatic cystic neoplasm (PCN). Glucose is an attractive alternative due to its availability and low cost.

We aimed at assess the role of intra-cystic glucose level in the diagnosis of mucinous PCN.

Methods Prospective observational study on consecutive patients with PCN receiving EUS FNA at the Endoscopy department of Campus Bio-medico University Hospital of Rome.

The cut-off of intra-cystic value used to distinguish mucinous cysts from not mucinous cysts was 50 mg/dl.

A p<0.05 was considered statistically significant.

Results From March 2018 to September 2021, 56 patients were enrolled (32% male; mean age 64±16 year old). Intra-cystic glucose<50 mg/dl was observed in 58.9%. The final diagnosis was “mucinous” in 51.7% PCN.

The mean value of intra-cystic glucose was lower in mucinous cyst (23±28 vs 56±42 p 0.001).

The presence of intra-cystic glucose<50 mg/dl was associated with higher rate of mucinous cysts (75.8% vs 24.1% p 0.01).

Sensibility was 75.8% (95% CI 56.5-89.7) and specificity was 59.3% (95% CI 38.8- 77.6). The PPV and the NPV were respectively 66.7% (95% CI 54.8-76.7) and 69.6% (95% CI 52.7-82.4).

A ROC curve analysis showed the best glucose cut-off of 66 mg/dl had a sensitivity of 93% and specificity of 52% (AUC 0.74 (p 0.001).

Conclusions Intra-cystic level of glucose is lower in mucinous cysts. A cut off of 66 mg/dl seems to have higher accuracy in the diagnosis of mucinous cysts but larger studies are necessary to confirm it.



Publication History

Article published online:
14 April 2022

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