Endoscopy 2022; 54(S 01): S278
DOI: 10.1055/s-0042-1745390
Abstracts | ESGE Days 2022
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VANEK’S TUMOR AS A RARE CAUSE OF DYSPEPTIC SYMPTOMS IN A WOMAN WITH PRIMARY BILIARY CHOLANGITIS: A CASE REPORT

R. Pellegrino
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
I. Panarese
2   University of Campania “Luigi Vanvitelli”, Mental and Physical Health and Preventive Medicine, Naples, Italy
,
N. De Gennaro
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
P. Ciamarra
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
K. Priadko
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
L. Granata
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
G. Palladino
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
G. Scidà
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
A. Facchiano
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
R. Franco
2   University of Campania “Luigi Vanvitelli”, Mental and Physical Health and Preventive Medicine, Naples, Italy
,
M. Romano
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
,
A.G. Gravina
1   University of Campania “Luigi Vanvitelli”, Precision Medicine, Naples, Italy
› Author Affiliations
 

Aims Vanek's Tumor is a rare mesenchymal gastrointestinal tumor. Different locations have been described and it is generally considered a benign lesion and characterized as a solitary/submucosal polypoid/nodular lesion. It's characterized by a hypocellular population, generally consisting of spindle-like cells, with soft ovoid nuclei, with little eosinophilic cytoplasm. We present a case of Vanek's Tumor.

Methods We presented a case of a 67-year-old patient with unclear dyspeptic syndrome and a history of primitive biliary cholangitis, non-bloody uterine fibroids as well as arthrosis of the right knee, and undergoing esophagogastroduodenoscopy because of dyspepsia unresponsive to symptomatic therapy. Family history was silent for gastrointestinal pathologies. A mild epigastric pain was the only clinical evidence.

Results Esophagogastroduodenoscopy showed a sessile mucosal formation at gastric angulus (diameter 10 millimeters). Random biopsies were taken from antrum, angulus and gastric body and targeted biopsies on the polypoid lesion were also taken because at Narrow Band Imaging examination it had no peculiar characteristics. On histology, we found gastric body-fundus type mucosa with moderate and quiescent chronic inflammation. One of the gastric body fragments showed elongated and branched foveola with focal cystic glandular dilatation (gastric hyperplastic polyp). Then polypectomy was performed which allowed to observe low cell density submucosa proliferation, consisting of spindle cells, with bland nuclei, irregularly arranged and immersed in an edematous-lax stroma, with numerous inflammatory elements including several eosinophils. An abundant vascular network was associated. CD34+, S100-, CD117-, ALK (d5f3 clone)- was found at immunohistochemistry.

Conclusions We were able to reach diagnosis of Vanek’s tumor of the stomach.



Publication History

Article published online:
14 April 2022

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