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DOI: 10.1055/s-0042-1746590
B-helper Neutrophils in Regional Lymph Nodes Correlate with Improved Survival of Head and Neck Cancer Patients
Introduction The role of neutrophils during cancer formation and elimination is not well understood. Here, we investigate neutrophil helper cells (NBH) and their influence on B cell properties in the regional lymph nodes (RLN) of head-and-neck cancer (HNC) patients.
Materials and methods Circulating and lymph node neutrophils of HNC patients with stage I–IV disease were investigated with flow cytometry and qPCR. Additionally, neutrophil/B cell co-localization in RLNs was analyzed using immunohistochemistry. B cell proliferation and patient survival were evaluated.
Results Neutrophils exhibited a helper cell phenotype. B cells in close proximity to such NBH of HNC patients showed significantly higher proliferation rates. NBH frequencies influenced patients’ survival
Conclusion Neutrophils in RLN influence T cell-independent activation pathways through B cell stimulation, positively correlating with patient prognosis.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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