Abstract
Objective Dermatophytoses, one of the most ancient diseases, is becoming a menace in recent
times. This has made the knowledge of antifungal susceptibility a priority in today's
times.
Material and Methods This is a prospective study conducted over 18 months including all dermatophytes
isolated during the period. Dermatophytes were identified by routine phenotypic methods.
Antifungal susceptibility testing was performed for griseofulvin, terbinafine, and
itraconazole as per the Clinical Laboratory Standard Institute M38 A2, and minimum
inhibitory concentrations (MICs) were read after 5 days.
Results Patient details and associated risk factors were recorded. Fixed dose combinations
with steroids were associated with 79.3% (46 out of 58) of patients with dermatophytosis
of skin. Among the 72 dermatophytes isolated during the study period, 58 (80.5%) were
isolated from skin scrapings and 14 (19.4%) from nail samples. Tinea corporis with
cruris was the most common presentation. The most common dermatophyte isolated from
skin scrapings was Trichophyton mentagrophytes complex (70.6%, 41 out of 58), while from nail samples it was Trichophyton rubrum complex (78.57%, 11 out of 14). Based on the MIC50 and MIC90 results, itraconazole showed the lowest MICs, followed by terbinafine and then griseofulvin.
Conclusion With the changing epidemiology of species distribution and antifungal resistance,
there is a need for continuous surveillance of these parameters of dermatophytes.
Keywords
Dermatophytes -
Trichophyton
- antifungal susceptibility - Griseofulvin - Terbinafine
