CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(01): 156-158
DOI: 10.1055/s-0042-1750069
Case Report

Contiguous Lumbar Vertebral Involvement with Vertebral Collapse in Giant Cell Tumor: A Usual Tumor with an Unusual Presentation

Ankita Soni
1   Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
,
Devinderpal Singh Dhanota
2   Department of Radiodiagnosis, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
,
Ruchita Tyagi
1   Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
,
Ashwani Kumar Chaudhary
3   Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
,
Harpreet Kaur
3   Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
,
Neena Sood
1   Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
› Author Affiliations
Funding None.

Abstract

Giant cell tumor (GCT) is a primary bone tumor of long bones, which can rarely involve the vertebrae. Contiguous vertebral involvement by GCT is a rare presentation and poses a diagnostic dilemma on imaging. We report a case of GCT involving three contiguous lumbar vertebrae causing vertebral collapse along with a large soft tissue component. Considering the site and clinical presentation, possibilities of a round cell tumor with large extraosseous soft tissue component and malignant neurogenic tumor were suggested on initial radiological examination but histopathology confirmed the diagnosis of GCT. It is important to diagnose this entity correctly because of totally different lines of management. In our case, initial surgical management was excluded in view of high surgical morbidity and, thereby, adjuvant therapy with denosumab was planned.

Authors' Contributions

A.S., D.S.D., and R.T. contributed to concept and design of the study, definition of intellectual content, literature search, clinical studies, experimental studies, data acquisition and analysis. A.S. and D.S.D. contributed to statistical analysis and manuscript editing. A.K.C. contributed to definition of intellectual content, literature search, clinical studies, experimental studies, and data acquisition and analysis. H.K. contributed to definition of intellectual content, clinical studies, data acquisition and analysis, statistical analysis and manuscript editing and reviewing. N.S. contributed to the study concept, definition of intellectual content, clinical and experimental studies, data analysis, and manuscript editing and reviewing. H.K. and N.S. are the guarantors of the study.




Publication History

Article published online:
26 July 2022

© 2022. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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