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CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(01): 146-148
DOI: 10.1055/s-0042-1750071
Case Report

Hemolytic Disease of Newborn due to ABO Incompatibility between B Blood Group Mother and A Blood Group Neonate

Suman S. Routray
1   Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India
,
Debasish Mishra
1   Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India
,
Girija N. Kanungo
1   Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India
,
Rachita Behera
1   Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India
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Abstract

ABO incompatibility between O blood group mother and non–O blood group neonate is common. It rarely causes anemia and hyperbilirubinemia in neonate, requiring invasive management. Direct antiglobulin test may be positive in these cases with immunoglobulin (Ig)-G antibody specificity. There are few cases of hemolytic disease of newborn due to ABO incompatibility between mother and newborn with non ̶ O blood group mother. After obtaining consent from the patient, we reported a case of incompatibility in a B blood group mother and A blood group neonate, and it was managed with phototherapy.

Keywords

ABO incompatibility - direct antiglobulin test - elution


Publication History

Article published online:
26 July 2022

© 2022. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Akanmu AS, Oyedeji OA, Adeyemo TA, Ogbenna AA. Estimating the risk of ABO hemolytic disease of the newborn in Lagos. J Blood Transfus 2015; 2015: 560738
    CrossrefPubMedGoogle Scholar
  • 2 Peevy KJ, Wiseman HJ. ABO hemolytic disease of the newborn: evaluation of management and identification of racial and antigenic factors. Pediatrics 1978; 61 (03) 475-478
    CrossrefPubMedGoogle Scholar
  • 3 Jain A, Malhotra S, Marwaha N, Kumar P, Sharma RR. Severe ABO hemolytic disease of fetus and newborn requiring blood exchange transfusion. Asian J Transfus Sci 2018; 12 (02) 176-179
    CrossrefPubMedGoogle Scholar
  • 4 Haque KM, Rahman M. An unusual case of ABO-haemolytic disease of the newborn. Bangladesh Med Res Counc Bull 2000; 26 (02) 61-64
    PubMedGoogle Scholar
  • 5 Usha KK, Sulochana PV. Detection of high risk pregnancies with relation to ABO haemolytic disease of newborn. Indian J Pediatr 1998; 65 (06) 863-865
    CrossrefPubMedGoogle Scholar
  • 6 Matteocci A, De Rosa A, Buffone E, Pierelli L. Retrospective analysis of HDFN due to ABO incompatibility in a single institution over 6 years. Transfus Med 2019; 29 (03) 197-201
    CrossrefPubMedGoogle Scholar
  • 7 Bujandric N, Grujic J. Exchange transfusion for severe neonatal hyperbilirubinemia: 17 years' experience from Vojvodina, Serbia. Indian J Hematol Blood Transfus 2016; 32 (02) 208-214
    CrossrefPubMedGoogle Scholar
  • 8 Sabzehei MK, Basiri B, Shokouhi M, Torabian S. Complications of exchange transfusion in hospitalised neonates in two neonatal centers in Hamadan, a five-year experience. Journal of Comprehensive Pediatrics 2015;6(02):
    Google Scholar
  • 9 Routray SS, Behera R, Mallick B. et al. The spectrum of hemolytic disease of the newborn: evaluating the etiology of unconjugated hyperbilirubinemia among neonates pertinent to immunohematological workup. Cureus 2021; 13 (08) e16940
    PubMedGoogle Scholar
  • 10 Wang R, Li Y, Tong Y, Su N. Hemolytic disease of the fetus and newborn caused by anti-group a IgG from a group B mother. J Pediatr Hematol Oncol 2021; 43 (06) e785-e787
    CrossrefPubMedGoogle Scholar
  • 11 Schooley N, Chabra S, Stolla M. From A to AB: A Caucasian mother with high anti-B titer causing hemolytic disease of the newborn. Lab Med 2022; 53 (02) e33-e35
    CrossrefPubMedGoogle Scholar
  • 12 Li P, Pang LH, Liang HF, Chen HY, Fan XJ. Maternal IgG anti-A and anti-B titer levels screening in predicting ABO hemolytic disease of the newborn: a meta-analysis. Fetal Pediatr Pathol 2015; 34 (06) 341-350
    CrossrefPubMedGoogle Scholar
  • 13 Kannan S, Kulkarni R, Basavarajegowda A. Prevalence of high titered anti-A and anti-B antibodies among O blood group individuals and their associated factors. Global Journal of Transfusion Medicine. 2020; 5 (02) 187
    CrossrefGoogle Scholar