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CC BY 4.0 · SynOpen 2023; 07(01): 8-16
DOI: 10.1055/s-0042-1751408
DOI: 10.1055/s-0042-1751408
paper
Selective Syntheses of Coumarin and Benzofuran Derivatives Using Phenols and α-Methoxy-β-ketoesters
This research was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant JP20J23632.
Abstract
Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols and α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans are formed in the presence of water. In the synthetic process of benzofurans, α-methoxy-β-ketoesters are converted into α-methoxyacetophenones, and the methoxy group is an important element in the intermolecular annulation.
Key words
coumarin - benzofuran - selective syntheses - phenol - α-methoxy-β-ketoester - α-methoxyacetophenoneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751408.
- Supporting Information
Publication History
Received: 11 December 2022
Accepted: 13 December 2022
Article published online:
26 January 2023
© 2023. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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