Synthesis, Table of Contents Synthesis 2024; 56(07): 1200-1206DOI: 10.1055/s-0042-1751517 paper Emerging Trends in Glycoscience Synthesis of the Hexasaccharide Repeating Unit Corresponding to the Cell Wall O-Antigen of Providencia alcalifaciens O9:H8 Strain Authors Abhijit Rana Anup Kumar Misra∗ Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract A straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Providencia alcalifaciens O9:H8 strain was achieved in very good yield by applying a stereo- and regioselective [4+2] block glycosylation strategy. The tetrasaccharide acceptor and disaccharide donor were synthesized by sequential stereo- and regioselective glycosylations. Thioglycoside and glycosyl trichloroacetimidate derivatives were used as glycosyl donors in the synthetic strategy. The glycosylation steps were high-yielding and gave satisfactory stereochemical outcomes. 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