Outpatient Use of Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Mild-to-Moderate Coronavirus Disease 2019

Antonio Riccardo Buonomo; Isabella Di Filippo; Nunzia Esposito; Gabriele Saccone; Mariano Nobile; Giulio Viceconte; Riccardo Villari; Costantino Di Carlo; Giuseppe Bifulco; Ivan Gentile

doi:10.1055/s-0042-1753488

American Journal of Perinatology, Table of Contents

Am J Perinatol 2024; 41(03): 365-367
DOI: 10.1055/s-0042-1753488

Short Communication

Outpatient Use of Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Mild-to-Moderate Coronavirus Disease 2019

Authors

Antonio Riccardo Buonomo

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy
Isabella Di Filippo

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy
Nunzia Esposito

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy
Gabriele Saccone

²Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, - Naples, Italy
Mariano Nobile

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy
Giulio Viceconte

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy
Riccardo Villari

²Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, - Naples, Italy
Costantino Di Carlo

²Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, - Naples, Italy
Giuseppe Bifulco

²Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, - Naples, Italy
Ivan Gentile

¹Department of Clinical Medicine and Surgery, Infectious Diseases Unit University “Federico II,” – Naples, Italy

Abstract

Objective The aim of this study was to report the use casirivimab/imdevimab therapy in pregnant women with moderate coronavirus disease 2019 (COVID-19).

Study Design We report 12 cases of unvaccinated pregnant patients with mild-to-moderate COVID-19 treated with casirivimab/imdevimab.

Results Twelve unvaccinated pregnant patients with mild-to-moderate COVID-19 received casirivimab/imdevimab at the dose of 1200/1200 mg by intravenous infusion over 60 minutes. All women were managed outpatient. None experienced severe adverse drug reaction and none progressed to severe disease.

Conclusion Casirivimab/imdevimab should be considered for outpatient treatment of unvaccinated pregnant women with mild-to-moderate COVID-19 to decrease the risk of severe disease.

Key Points

Casirivimab/imdevimab is not well studied in pregnant women.
Casirivimab/imdevimab in pregnant women with mild-to-moderate COVID-19 decreases the risk of severe disease.
Casirivimab/imdevimab in pregnant women with mild-to-moderate COVID-19 is well tolerated.

Keywords

COVID-19 - infection - NICU - preterm birth

Full Text

References

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