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Primary Bilateral Ovarian Lymphoma: A Rare Case Report
Primary ovarian lymphomas constitute 0.5% of all ovarian malignancies. We report one such case in a middle-aged woman who presented with a bilateral ovarian tumor. Bilateral oophorectomy with salpingectomy was sent for frozen section analysis that revealed a round cell tumor. Final histopathology showed a mitotically active small round blue cell tumor arranged in diffuse sheets and chords with an evident starry-sky pattern. Extensive immunohistochemistry (IHC) panel was performed. Histopathology along with IHC did not classify the tumor into diffuse-large-B cell-lymphoma or Burkitt lymphoma and a final diagnosis of high-grade B cell lymphoma (HGBL) was made. This case is presented for its rarity and to discuss the challenges on IHC to subclassify a lymphoma as HGBL. Although rare, the possibility of primary ovarian non-Hodgkin lymphoma should be kept in mind when dealing with bilateral ovarian tumors as a timely and accurate diagnosis can save unnecessary surgeries and improve outcome.
Keywordsprimary ovarian lymphoma - high-grade B cell lymphoma - bilateral ovarian non-hodgkin lymphoma
Article published online:
25 July 2022
© 2022. Spring Hope Cancer Foundation & Young Oncologist Group of Asia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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- 1 Ferry JA, McCluggage WG, Daya D. et al. Lymphoid and myeloid tumors. In: Robert JK, Maria LC, Simon CH, Robert HY. eds. WHO Classification of Tumours of Female Reproductive Organs. 4th Edition,. Lyon: IARC Press; 2014
- 2 Afshan A, Sadaf N. Primary ovarian lymphoma–a rare entity. J Pak Med Assoc 2013; 63 (04) 519-520
- 3 Nwanze J, Siddiqui MT, Stevens KA, Saxe D, Cohen C. MYC Immunohistochemistry predicts MYC rearrangements by FISH. Front Oncol 2017; 7: 209
- 4 Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, Thiele J. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: International Agency for Research on Cancer; 2017
- 5 Senol T, Doger E, Kahramanoglu I. et al. Five cases of non-hodgkin B-cell lymphoma of the ovary. Case Rep Obstet Gynecol. 2014 392758. doi:10.1155/2014/392758