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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2022; 32(03): 287-293
DOI: 10.1055/s-0042-1755251
Original Article

Diagnostic Performance of Acoustic Radiation Force Impulse Imaging in Evaluating Liver Fibrosis in Patients with Chronic Hepatitis B Infection: A Cross-Sectional Study

Hoang Huu Bui 
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
2   Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
,
Van Huy Vo 
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
,
Chuong Dinh Nguyen 
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
,
Sang The Phan
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
,
Phong Tien Quach
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
,
Dung Bich Nguyen
1   Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
› Author Affiliations
Funding None.
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Abstract

Background Acoustic radiation force impulse point shear wave elastography (ARFI-pSWE), measuring shear-wave velocity (SWV), has been utilized to examine the liver stiffness caused by different etiologies. However, information on its reliability in staging liver fibrosis in chronic hepatitis B (CHB) patients is scarce.

Purpose The aim of the study is to examine the diagnostic performance of ARFI-pSWE and determine the optimal SWV cut-off values to predict significant fibrosis (F ≥2) and cirrhosis (F4) in CHB patients.

Material and Methods All 114 adult CHB patients visiting the University Medical Center, Ho Chi Minh City, Vietnam between February 2019 and March 2021 underwent liver stiffness measurement using ARFI-pSWE and FibroScan. SWV results were tested against FibroScan for sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The area under the receiver operating characteristic (AUROC) curve was used to identify the optimal SWV cut-off values.

Results There was a strong agreement between ARFI-pSWE and FibroScan (r = 0.92, p <0.001). The optimal SWV cut-off value for detecting significant fibrosis was 1.37 m/s with an AUROC of 0.975, sensitivity of 83.3%, specificity of 100%, PPV of 100%, and NPV of 81%. The optimal cut-off value for predicting cirrhosis was 1.70 m/s with an AUROC of 0.986, sensitivity of 97%, specificity of 93%, PPV of 95%, and NPV of 96%.

Conclusion ARFI-pSWE could be an effective technique for evaluating liver fibrosis in CHB patients. SWV cut-off values of 1.37 and 1.70 m/s could be used to diagnose significant fibrosis and cirrhosis, respectively.

Keywords

chronic hepatitis B - liver fibrosis - ARFI - point shear wave elastography - FibroScan

Authors' Contributions

The trial was designed by H.H.B., together with V.H.V., S.T.P., P.T.Q. B.D.N. collected the data. C.D.N. analyzed the data. H.H.B., V.H.V., and C.D.N. wrote the manuscript. H.H.B., C.D.N., S.T.P., P.T.Q., and B.D.N. revised the manuscript. All authors approved the final version of the manuscript.


Presentation at a Meeting

This study was presented as an e-poster in Singapore Hepatology Conference 2021, October 11 to 15th.


Research Ethics and Patient Consent

Written informed consent was obtained from all study participants. The study was approved by the Ethics Committee of the University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam (Reference No. 71/2019/HĐ-ĐHYD) and was performed in accordance with the ethical principles of the Declaration of Helsinki.




Publication History

Article published online:
30 August 2022

© 2022. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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