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CC BY-NC-ND 4.0 · Avicenna J Med 2022; 12(03): 148-153
DOI: 10.1055/s-0042-1755389
Original Article

Serum SCUBE-1 Levels and Return of Spontaneous Circulation Following Cardiopulmonary Resuscitation in Adult Patients

Cahit Yılmaz
1   Department of Emergency Medicine, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey
,
Bedia Gülen 
2   Department of Emergency Medicine, İstanbul Medipol University, Istanbul, Turkey
,
Ertan Sönmez 
3   Department of Emergency Medicine, Bezmialem Foundation University, Istanbul, Turkey
,
Dursun Akbay
4   Private Practice, Bezmialem Foundation University, Istanbul, Turkey
,
Özgür Söğüt
5   Department of Emergency Medicine, University of Health Sciences Haseki Training and Research Hospital, Istanbul, Turkey
,
Serdar Özdemir 
1   Department of Emergency Medicine, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey
,
Ömer Faruk Özer 
6   Department of Biochemistry, Bezmialem Foundation University, Istanbul, Turkey
› Author Affiliations Funding This study was funded by the Bezmialem Vakıf Üniversitesi BAP Koordinasyon Birimi (number:12.2015/16).
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Abstract

Background SCUBE 1-has been used as a biomarker for the diagnoses of myocardial infarction, stroke, mesenteric ischemia, and gastric cancer in some recent studies. In this study, we investigated the relationship between serum SCUBE−1 levels and return of spontaneous circulation (ROSC) in patients who received cardiopulmonary resuscitation (CPR).

Methods Patients over 18 years of age who were not pregnant and received CPR were divided into two groups: those who achieved ROSC and those who died. There were 25 patients in each group. SCUBE−1 and other routine biochemical parameters were studied in blood samples taken at the time of admission.

Results There was no significant difference between the age and gender distribution of the patients between the two groups. The SCUBE−1 value of the ROSC group was significantly higher than that of the non-survivor group (p ˂ 0.05). At a cut-off value of 9 ng/mL, SCUBE−1 had a sensitivity of 100%, a positive predictive value of 65.8%, specificity of 48%, and a negative predictive value of 100% in predicting ROSC.

Conclusions The SCUBE−1 values were found to be significantly higher in the ROSC group compared with the non-survivor group.

Keywords

cardiopulmonary resuscitation - peptides - SCUBE−1 protein


Publication History

Article published online:
05 September 2022

© 2022. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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