Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst

Austin Gamblin; Jarom Gropp; Vance L. Fredrickson; Hediyeh Baradaran; William T. Couldwell

doi:10.1055/s-0042-1756628

Asian Journal of Neurosurgery, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Asian J Neurosurg 2022; 17(03): 507-510
DOI: 10.1055/s-0042-1756628

Case Report

Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst

Authors

Austin Gamblin

¹School of Medicine, University of Utah, Salt Lake City, Utah, United States
Jarom Gropp

¹School of Medicine, University of Utah, Salt Lake City, Utah, United States
Vance L. Fredrickson

²Department of Radiology, University of Utah, Salt Lake City, Utah, United States
Hediyeh Baradaran

³Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States
William T. Couldwell

³Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States

Abstract

Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are uncommon benign lesions that are rarely diagnosed radiographically. We report an unusual case of a left middle cerebellar peduncle CAPNON with vasogenic edema and a perilesional cyst. The patient was a 36-year-old woman with a 20-year history of left-sided hearing loss that had recently progressed. Computed tomography and magnetic resonance imaging showed a heterogenous calcified lesion with vasogenic edema and a perilesional cyst in the left middle cerebellar peduncle. Although it is a rare radiographic feature of CAPNON, vasogenic edema should be included as a possible feature of this uncommon tumefactive lesion.

Keywords

calcifying pseudoneoplasms - case report - CAPNON - microsurgery - perilesional cyst - vasogenic edema

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Referenzen

References
1 Ho ML, Eschbacher KL, Paolini MA, Raghunathan A. New insights into calcifying pseudoneoplasm of the neuraxis (CAPNON): a 20-year radiological-pathological study of 37 cases. Histopathology 2020; 76 (07) 1055-1069
2 Rhodes RH, Davis RL. An unusual fibro-osseous component in intracranial lesions. Hum Pathol 1978; 9 (03) 309-319
3 Yang K, Reddy K, Chebib I, Hammond R, Lu JQ. Calcifying pseudoneoplasm of the neuraxis (CAPNON): from pathogenesis to diagnostic and therapeutic considerations. World Neurosurg 2021; 148: 165-176
4 Lu JQ, Popovic S, Provias J, Cenic A. Collision lesions of calcifying pseudoneoplasm of the neuraxis and rheumatoid nodules: a case report with new pathogenic insights. Int J Surg Pathol 2021; 29 (03) 314-320
5 Ghaemi J, Wasimi M, Siripurapu R. et al. Calcifying pseudoneoplasm of the neuraxis (CaPNoN): an unusual cause of third nerve palsy in a teenager. BJR Case Rep 2016; 2 (03) 20150494
6 Lopes AJ, Brock RS, Martins TG. et al. Intradural calcifying pseudoneoplasm of the neuraxis presenting as a cauda equina syndrome. Surg Neurol Int 2016; 7 (Suppl. 42) S1102-S1105
7 Vallejo FA, Chen SH, Bano G, Gultekin S, Morcos J. Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: case report and literature review. J Clin Neurosci 2020; 78: 439-443
8 Wiśniewski K, Janczar K, Tybor K, Papierz W, Jaskólski DJ. Calcifying pseudoneoplasm of the foramen magnum–case report and review of the literature. Br J Neurosurg 2015; 29 (06) 891-893
9 Yang K, Reddy K, Wang BH. et al. Immunohistochemical markers in the diagnosis of calcifying pseudoneoplasm of the neuraxis. Can J Neurol Sci 2021; 48 (02) 259-266
10 Fletcher AM, Greenlee JJ, Chang KE, Smoker WR, Kirby PA, O'Brien EK. Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension. J Clin Neurosci 2012; 19 (07) 1048-1049
11 Barber SM, Low JCM, Johns P, Rich P, MacDonald B, Jones TL. Calcifying pseudoneoplasm of the neuraxis: a case illustrating natural history over 17 years of radiologic surveillance. World Neurosurg 2018; 115: 309-319
12 Conway KS, Jentzen J, Pratt D, Camelo-Piragua S. Sudden death due to calcifying pseudoneoplasm of the neuraxis: a case report and a review of sudden death due to undiagnosed central nervous system mass lesions. Am J Forensic Med Pathol 2020; 41 (01) 70-74
13 Brasiliense LB, Dickson DW, Nakhleh RE, Tawk RG, Wharen R. Multiple calcifying pseudoneoplasms of the neuraxis. Cureus 2017; 9 (02) e1044
14 Hubbard M, Qaiser R, Clark HB, Tummala R. Multiple calcifying pseudoneoplasms of the neuraxis. Neuropathology 2015; 35 (05) 452-455
15 Bertoni F, Unni KK, Dahlin DC, Beabout JW, Onofrio BM. Calcifying pseudoneoplasms of the neural axis. J Neurosurg 1990; 72 (01) 42-48
16 Qian J, Rubio A, Powers JM. et al. Fibro-osseous lesions of the central nervous system: report of four cases and literature review. Am J Surg Pathol 1999; 23 (10) 1270-1275
17 Aiken AH, Akgun H, Tihan T, Barbaro N, Glastonbury C. Calcifying pseudoneoplasms of the neuraxis: CT, MR imaging, and histologic features. AJNR Am J Neuroradiol 2009; 30 (06) 1256-1260
18 Yang K, Reddy K, Ellenbogen Y, Wang BH, Bojanowski MW, Lu JQ. Skull base calcifying pseudoneoplasms of the neuraxis: two case reports and a systematic review of the literature. Can J Neurol Sci 2020; 47 (03) 389-397
19 Paolini MA, Ho ML, Monahan HR, Raghunathan A. Supratentorial CAPNON associated with WHO grade II meningioma: a case report. Neuropathology 2018; 38 (05) 535-538
20 Inukai M, Shibahara I, Hotta M. et al. Case of calcifying pseudoneoplasms of the neuraxis coexisting with interhemispheric lipoma and agenesis of the corpus callosum: involvement of infiltrating macrophages. World Neurosurg 2020; 134: 635-640.e1
21 Watanabe A, Nakanishi K, Kataoka K, Wakasa T, Ohta Y. Regrowth and progression of multiple calcifying pseudoneoplasms of the neuraxis: case report. Surg Neurol Int 2018; 9: 243
22 Higa N, Yokoo H, Hirano H. et al. Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low-grade glioma: a case report and review of the literature. Neuropathology 2017; 37 (05) 446-451
23 Chang H, Park JB, Kim KW. Intraosseous calcifying pseudotumor of the axis: a case report. Spine 2000; 25 (08) 1036-1039
24 Fetsch JF, Montgomery EA, Meis JM. Calcifying fibrous pseudotumor. Am J Surg Pathol 1993; 17 (05) 502-508