CC BY 4.0 · Journal of Health and Allied Sciences NU 2023; 13(03): 332-336
DOI: 10.1055/s-0042-1758036
Review Article

Factors Influencing the Aggressive Behavior of Odontogenic Keratocyst: A Narrative Review

Reshma Amin
1   Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Science, Department of Oral Pathology, Mangalore
Avaneendra Talwar
2   Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Science, Mangalore
› Institutsangaben
Funding None.


During odontogenesis, the dental lamina disintegrates, leaving behind the remnants. Odontogenic pathologies such as cysts and tumors can arise from these remnants. The odontogenic keratocyte (OKC) arises from dental lamina remnants. Among the cysts, the odontogenic keratocyst is the most controversial. There is convincing evidence that inflammation plays a significant role in the pathogenesis and expansion of OKCs. Several factors mediate the proliferative capacity of the epithelial lining. The presence of mast cells close to the epithelial lining, cystic pressure build-up by vascular endothelial growth factors (VEGFs), and other cytokines contribute to the cystic expansion. Fibroblast activation by inflammation in the connective tissue stroma and changes in the epithelial lining are responsible for the aggressive nature of OKC. The use of molecular methodologies gives more profound insights into the factors influencing the progression of the lesion and helps develop newer treatment modalities for OKC. This review describes the characteristics that determine the aggressive behavior of this unique cyst.


Artikel online veröffentlicht:
23. November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (

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