Expression of microRNA Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease

Oliver Buchhave Pedersen; Erik Lerkevang Grove; Peter H. Nissen; Sanne Bøjet Larsen; Leonardo Pasalic; Steen Dalby Kristensen; Anne-Mette Hvas

doi:10.1055/s-0042-1760258

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2023; 123(03): 307-316
DOI: 10.1055/s-0042-1760258

Cellular Haemostasis and Platelets

Expression of microRNA Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease

Oliver Buchhave Pedersen

¹Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

²Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

³Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

,

Erik Lerkevang Grove

²Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

³Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

,

Peter H. Nissen

¹Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

³Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

,

Sanne Bøjet Larsen

²Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

,

Leonardo Pasalic

⁴Department of Clinical and Laboratory Haematology, Institute of Clinical Pathology and Medical Research, Westmead University Hospital, Sydney, Australia

⁵Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia

,

Steen Dalby Kristensen

²Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

³Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

,

Anne-Mette Hvas

¹Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

³Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

› Institutsangaben

Abstract

Background New biomarkers are warranted to identify patients with coronary artery disease (CAD) at high risk of recurrent cardiovascular events. It has been reported that the expression of microRNAs (miRs) may influence the development of CAD.

Objectives We aimed to investigate whether the expression of selected candidate miRs is a predictor of cardiovascular events in a cohort of stable CAD patients.

Methods We performed a single-center prospective study of 749 stable CAD patients with a median follow-up of 2.8 years. We investigated the expression of nine candidate miRs and their relation to cardiovascular events in this cohort. The primary endpoint was the composite of nonfatal myocardial infarction (MI), stent thrombosis (ST), ischemic stroke, and cardiovascular death. The composite of nonfatal MI and ST was analyzed as a secondary endpoint. Furthermore, nonfatal MI, ST, ischemic stroke, and all-cause mortality were analyzed as individual endpoints.

Results Employing receiver operating characteristic curves, it was shown that compared with traditional cardiovascular risk factors alone, combining the expression of miR-223–3p with existing traditional cardiovascular risk factors increased the predictive value of ST (area under the curve: 0.88 vs. 0.77, p = 0.04), the primary composite endpoint (0.65 vs. 0.61, p = 0.049), and the secondary endpoint of the composite of nonfatal MI and ST (0.68 vs. 0.62, p = 0.04).

Conclusion Among patients with CAD, adding miR-223–3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST. Clinical trials confirming these findings are warranted.

Keywords

coronary artery disease - microRNAs - myocardial infarction - risk factors

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Referenzen

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