Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection among Hospitalized Under-5s in Northwestern Nigeria

Maria Ahuoiza Garba; Fatima Jummai Giwa; Hamdala Adelaiye; Abiola Aira Olorukooba; Fatima Abdullahi; Hauwa Makarfi; Yvette Löwensteyn; Louis Bont; Fadlullah Abdurraheem; Ehi Uudu; Halima Mudasir; Natalie I Mazur

doi:10.1055/s-0042-1760446

Journal of Pediatric Infectious Diseases, Table of Contents

J Pediatr Infect Dis 2023; 18(02): 101-106
DOI: 10.1055/s-0042-1760446

Original Article

Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection among Hospitalized Under-5s in Northwestern Nigeria

Authors

Maria Ahuoiza Garba

¹Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Fatima Jummai Giwa

²Department of Medical Microbiology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Hamdala Adelaiye

³Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Kaduna State, Nigeria
Abiola Aira Olorukooba

¹Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Fatima Abdullahi

¹Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Hauwa Makarfi

¹Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Yvette Löwensteyn

⁴Department of Pediatric Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
Louis Bont

⁴Department of Pediatric Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
Fadlullah Abdurraheem

³Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Kaduna State, Nigeria
Ehi Uudu

³Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Kaduna State, Nigeria
Halima Mudasir

³Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Kaduna State, Nigeria
Natalie I Mazur

⁴Department of Pediatric Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands

Abstract

Objective Globally, 33 million cases of respiratory syncytial virus (RSV) infections occur annually among under-fives (5s). Ninety-nine percent of deaths from RSV occur in low- and middle-income countries. Under-five pneumonia mortality in Nigeria was estimated at 140,520 in 2017, but RSV epidemiological data are scant due to poor awareness and limited testing. Vaccines for RSV are currently under development and RSV mortality data from this high mortality, low resource setting are essential to maximizing the potential benefit of vaccination as well as promoting vaccine uptake. This study aimed to describe the epidemiology of RSV-associated acute lower respiratory tract infection (ALRTI) in children younger than 5 years in Zaria, Northwestern Nigeria.

Methods A prospective cohort study was conducted among children aged 1 month to 5 years who were hospitalized with ALRTI in the Emergency Pediatric Unit of a tertiary hospital in Zaria from November 2018 to October 2019. Naso-pharyngeal swabs were obtained for RSV testing using a point-of-care immunoassay technique.

Results Thirty-three percent (35/106) of the children had RSV-related ALRTI. The median age of RSV-positive cases was 8 months (IQR 3–14). Two-thirds of children (68.6%, 24/35) were below 12 months. The RSV mortality rate was 5.7% (2/35). RSV occurred in 10 months of the year with peaks in March and July.

Conclusion A third of admitted children with ALRTI were positive for RSV. Therefore RSV significantly contributes to childhood pneumonia and the dual seasonal peak observed in our study may have implications for vaccine implementation.

Keywords

respiratory syncytial virus - prevalence - epidemiology - seasonality - under-5s

Full Text

References

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