Neurology International Open 2017; 01(04): E287-E293
DOI: 10.1055/s-0043-107843
Review
© Georg Thieme Verlag KG Stuttgart · New York

Role of the Gut Microbiota in Ischemic Stroke

Katarzyna Winek1, 2, 3, Ulrich Dirnagl1, 2, 3, 4, 5, 6, Andreas Meisel1, 2, 3, 4
  • 1Experimentelle Neurologie, Charité – Universitätsmedizin Berlin
  • 2NeuroCure Clinical Research, Charité – Universitätsmedizin Berlin
  • 3Centrum für Schlaganfallforschung Berlin, Charité – Universitätsmedizin Berlin
  • 4Klinik für Neurologie, Charité – Universitätsmedizin Berlin
  • 5Deutsches Zentrum für neurodegenerative Erkrankungen (DZNE), Standort Berlin
  • 6Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Standort Berlin
Further Information

Publication History

Publication Date:
17 October 2017 (online)

Abstract

Recent studies have provided evidence for the role of the gut microbiota in the homeostasis of the central nervous system (CNS) and in the pathophysiology of its disorders, e. g. by regulation of the peripheral immune response. In this article, we discuss the importance of the gut microbiota in stroke by providing a summary of available clinical and experimental data suggesting that 1) stroke changes the gut microbiome, 2) microbiota modulates stroke outcome and 3) microbiota plays an important role in the pathogenesis of stroke (risk factors). Currently available clinical and experimental evidence suggests an important role of gut microbiota in stroke and promises clinically relevant discoveries within coming years.