Planta Med 2017; 83(17): 1313-1320
DOI: 10.1055/s-0043-108650
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Anti-inflammatory, Antipyretic, and Antinociceptive Effects of a Cressa cretica Aqueous Extract

Heba Mohammed Ibrahim Abdallah1, Abdelsamed Ibrahim Elshamy2, Abd El-Nasser Gaber El Gendy3, Ahmed Mohamed Abd El-Gawad4, Elsayed Abouelfotowh Omer3, Marinella De Leo5, Luisa Pistelli5
  • 1Pharmacology Department, National Research Centre, Dokki, Giza, Egypt
  • 2Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt
  • 3Medicinal and Aromatic Plants Research Department, National Research Centre, Dokki, Giza, Egypt
  • 4Department of Botany, Mansoura University, Mansoura, Egypt
  • 5Dipartimento di Farmacia, Università di Pisa, Pisa, Italy
Further Information

Publication History

received 07 December 2016
revised 01 March 2017

accepted 31 March 2017

Publication Date:
24 April 2017 (eFirst)


Cressa cretica is a widely grown halophytic plant traditionally used for the treatment of different ailments. Previous investigations reported its biological activity on a wide spectrum of diseases. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. C. cretica showed writhing inhibition in acetic acid-induced peripheral nociception of 43 and 48 % at doses of 50 and 100 mg/kg, respectively. The same doses increased latency time in a hot plate model of central analgesia by 66 and 78 % compared to the control group, respectively. The acute anti-inflammatory effect of the extract was explored in the carrageenan-induced rat hind paw test. The inhibition of paw volume was better than that of the standard drug indomethacin. C. cretica significantly decreased rectal temperature in the rats injected with Brewerʼs yeast. C. cretica aqueous extract showed both central and peripheral antinociceptive activities and was effective as an anti-inflammatory and antipyretic. Phenolic compounds, including chlorogenic acids and flavonol glycosides, were identified by HPLC-PDA-ESI-MS techniques. These findings indicate the medicinal importance of this traditionally used plant as a therapeutic remedy for different ailments.