Planta Med
DOI: 10.1055/s-0043-109567
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Denudatin A, a Dimeric Acylphloroglucinol from Hypericum denudatum Presents an Antinociceptive Effect in Mice

Henrique Bridi1, Gabriela de Carvalho Meirelles1, Sérgio Augusto de Loreto Bordignon2, Stela Maris Kuze Rates1, Gilsane Lino von Poser1
  • 1Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • 2Programa de Pós Graduação em Avaliação de Impactos Ambientais, UNILASALLE, Canoas, Brazil
Further Information

Publication History

received 27 January 2017
revised 05 April 2017

accepted 19 April 2017

Publication Date:
04 May 2017 (eFirst)

Abstract

A new dimeric acylphloroglucinol, denudatin A (1), was isolated from the flowering aerials parts of Hypericum denudatum, along with the known phloroglucinols selancin A (2), hyperbrasilol A (3), uliginosin B (4), and isouliginosin B (5). The structure of 1 was elucidated using 1D, 2D NMR, and MS experiments, and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Denudatin A (1) and selancin A (2) were administered orally to mice displaying antinociceptive activity in the hot plate test. The compounds did not induce motor impairment in the rotarod apparatus.

Supporting Information