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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2017; 77(07): 780-785
DOI: 10.1055/s-0043-109867
GebFra Science
Original Article
Georg Thieme Verlag KG Stuttgart · New York

The Incidence and Effects of Alloimmunization in Pregnancy During the Period 2000 – 2013

Die Häufigkeit und Effekte der Immunisierung während der Schwangerschaft im Zeitraum 2000 – 2013
Marjana Jerković Raguž
1   Department of Neonatology and Intensive Care Unit, Clinic for Childrenʼs Diseases, University Clinical Hospital Mostar, Bosnian and Herzegovina
,
Darinka Šumanovic Glamuzina
1   Department of Neonatology and Intensive Care Unit, Clinic for Childrenʼs Diseases, University Clinical Hospital Mostar, Bosnian and Herzegovina
,
Jerko Brzica
1   Department of Neonatology and Intensive Care Unit, Clinic for Childrenʼs Diseases, University Clinical Hospital Mostar, Bosnian and Herzegovina
,
Tonći Gruica
2   Department of Gynecology and Obstetrics General Hospital Šibenik, Croatia
› Author Affiliations
Further Information

Publication History

received 26 February 2017
revised 20 April 2017

accepted 26 April 2017

Publication Date:
17 July 2017 (online)

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Abstract

Introduction The objective of the analysis was to examine the epidemiological aspects of maternal alloimmunization and to determine the most common antibody specificities resulting in hemolytic disease of the newborn (HDN).

Materials and Methods The retrospective epidemiological study encompasses all pregnant women who underwent immunohematological screening and the newborn treated for HDN in the period from 2000 to 2013 in the Herzegovina region.

Results The indirect Coombs test (ICT) detected antibodies against antigens in 384 (2.4%) pregnant women of the 18 800 who were tested at the Department of Transfusion Medicine. The direct Coombs test (DCT) detected antibodies against antigens in 160 (0.8%) newborn treated for HDN. The results of our 13-year study, in which 60% of the pregnant women had non-RhD antibodies, confirms this finding.

Conclusion However, we have reached the 21st century and the burden of alloimmunisation in pregnancy is still on our backs. The problem of immunization and HDN is still present in our region, which is a neonatal and public health problem.

Zusammenfassung

Einführung Das Ziel dieser Analyse war die Untersuchung von epidemiologischen Aspekten der häufigsten Antikörperspezifitäten, die zu einem Morbus haemolyticus neonatorum (MHN) führen können.

Methode Die retrospektive Studie umfasste alle Schwangeren, bei denen im immunhämatologischen Screening ein erythrozytärer Antikörper entdeckt wurde, sowie Neugeborene, die im Zeitraum von 13 Jahren (2000 – 2013) in der Region Herzegowina wegen MHN behandelt wurden.

Ergebnisse Der indirekte Coombs-Test (ICT) war positiv bei 384 (2,4%) von insgesamt 18 800 an der Abteilung für Transfusionsmedizin getesteten Schwangeren. Der direkte Coombs-Test (DCT) war positiv bei 160 (0,8%) der Neugeborenen, die wegen MHN behandelt wurden. Das Ergebnis der 13-jährigen Untersuchung zeigte, dass 60% der Schwangeren Anti-Rh-D-Antikörper haben.

Schlussfolgerung Das Immunisierungsproblem und MHN sind weiterhin erheblich vorhanden in der Region Herzegowina, was ein neonatales und öffentlich-gesundheitliches Problem darstellt.

Key words

newborn - hemolytic disease - sensitization

Schlüsselwörter

Neugeborene - Morbus haemolyticus neonatorum - Antikörperspezifitäten
 

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