Three New Abietane-Type Diterpenoids from Plectranthus africanus and Their Antibacterial Activities

Raïssa T. Nzogong; Blaise K. Nganou; Alex T. Tedonkeu; Maurice D. Awouafack; Mathieu Tene; Takuya Ito; Pierre Tane; Hiroyuki Morita

doi:10.1055/s-0043-114426

Planta Medica, Inhaltsverzeichnis

Planta Med 2018; 84(01): 59-64
DOI: 10.1055/s-0043-114426

Natural Product Chemistry and Analytical Studies

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Three New Abietane-Type Diterpenoids from Plectranthus africanus and Their Antibacterial Activities

Autoren

Raïssa T. Nzogong

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Blaise K. Nganou

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Alex T. Tedonkeu

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Maurice D. Awouafack

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

²Institute of Natural Medicine, University of Toyama, Toyama, Japan
Mathieu Tene

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Takuya Ito

²Institute of Natural Medicine, University of Toyama, Toyama, Japan
Pierre Tane

¹Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Hiroyuki Morita

²Institute of Natural Medicine, University of Toyama, Toyama, Japan

Abstract

Three new abietane-type diterpenoids, plectranthroyleanones A – C (1 – 3), together with five known compounds (4 – 8) were isolated from the methanol extract of the whole plant of Plectranthus africanus using column chromatography techniques. The structures of the new compounds were elucidated using a combination of 1D and 2D NMR and HRESIMS analyses. Compound 1 exhibited weak activities with minimal inhibitory concentration values of 75 µg/mL against gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, and 150 µg/mL against two gram-negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumoniae, respectively, while 2 and 3 had moderate antibacterial activity against K. pneumoniae with a minimal inhibitory concentration value of 37.5 µg/mL.

Key words

Plectranthus africanus - Lamiaceae - abietanes - plectranthroyleanone - antibacterial activity

Volltext

Referenzen

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