Planta Med
DOI: 10.1055/s-0043-117742
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Potential Anti-inflammatory Sesquiterpene Lactones from Eupatorium lindleyanum

Fang Wang1, 2, *, Huanhuan Zhong1, *, Shiqi Fang1, Yunfeng Zheng1, 3, Cunyu Li1, 3, Guoping Peng1, 3, Xinchun Shen2
  • 1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
  • 2College of food science and Engineering, Nanjing University of Finance and Economics, Nanjing, P. R. China
  • 3Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, P. R. China
Further Information

Publication History

received 13 April 2017
revised 12 July 2017

accepted 23 July 2017

Publication Date:
09 August 2017 (eFirst)


Eupatorium lindleyanum has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from E. lindleyanum led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1) and eupalinolide M (2), and seven known sesquiterpene lactones (39). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques. In vivo experiments showed that the sesquiterpenes fraction significantly reduced mouse ear edema induced by xylene (18.6%, p < 0.05). In in vitro assays, compounds 19 showed excellent anti-inflammatory activities, as they lowered TNF-α and IL-6 levels in lipopolysaccharide-stimulated murine macrophage RAW 264.7 cells (p < 0.001). The above results suggest that the sesquiterpene lactones from E. lindleyanum can be developed as novel potential natural anti-inflammatory agents.

* These authors contributed equally to this work.

Supporting Information