Planta Med 2018; 84(02): 123-128
DOI: 10.1055/s-0043-117742
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Potential Anti-inflammatory Sesquiterpene Lactones from Eupatorium lindleyanum

Fang Wang*
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
College of food science and Engineering, Nanjing University of Finance and Economics, Nanjing, P. R. China
,
Huanhuan Zhong*
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
,
Shiqi Fang
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
,
Yunfeng Zheng
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, P. R. China
,
Cunyu Li
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, P. R. China
,
Guoping Peng
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, P. R. China
,
Xinchun Shen
College of food science and Engineering, Nanjing University of Finance and Economics, Nanjing, P. R. China
› Author Affiliations
Further Information

Publication History

received 13 April 2017
revised 12 July 2017

accepted 23 July 2017

Publication Date:
09 August 2017 (eFirst)

Abstract

Eupatorium lindleyanum has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from E. lindleyanum led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1) and eupalinolide M (2), and seven known sesquiterpene lactones (39). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques. In vivo experiments showed that the sesquiterpenes fraction significantly reduced mouse ear edema induced by xylene (18.6%, p < 0.05). In in vitro assays, compounds 19 showed excellent anti-inflammatory activities, as they lowered TNF-α and IL-6 levels in lipopolysaccharide-stimulated murine macrophage RAW 264.7 cells (p < 0.001). The above results suggest that the sesquiterpene lactones from E. lindleyanum can be developed as novel potential natural anti-inflammatory agents.

* These authors contributed equally to this work.


Supporting Information