Endoscopy 2018; 50(02): 142-147
DOI: 10.1055/s-0043-119212
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Magnified endoscopic observation of small depressed gastric lesions using linked color imaging with indigo carmine dye

Yoshiyasu Kitagawa
1  Endoscopy Division, Chiba Cancer Center, Chiba, Japan
,
Taro Hara
2  Hara Clinic, Chiba, Japan
,
Dai Ikebe
3  Division of Surgical Pathology, Chiba Cancer Center, Chiba, Japan
,
Rino Nankinzan
1  Endoscopy Division, Chiba Cancer Center, Chiba, Japan
,
Hideyuki Takashiro
1  Endoscopy Division, Chiba Cancer Center, Chiba, Japan
,
Ryosuke Kobayashi
1  Endoscopy Division, Chiba Cancer Center, Chiba, Japan
,
Kazuyoshi Nakamura
4  Department of Gastroenterology, Chiba Cancer Center, Chiba, Japan
,
Taketo Yamaguchi
4  Department of Gastroenterology, Chiba Cancer Center, Chiba, Japan
,
Takuto Suzuki
1  Endoscopy Division, Chiba Cancer Center, Chiba, Japan
› Author Affiliations
Further Information

Publication History

submitted 16 February 2017

accepted after revision 04 August 2017

Publication Date:
27 September 2017 (eFirst)

Abstract

Background and study aims Magnifying linked color imaging with indigo carmine dye (M-Chromo-LCI) enables sterically enhanced and color image-magnified observation of the superficial gastric mucosa. This study investigated the usefulness of M-Chromo-LCI for the differential diagnosis of gastric lesions.

Patients and methods 100 consecutive small depressed lesions were examined with conventional white-light imaging (C-WLI), magnifying blue-laser imaging (M-BLI), and M-Chromo-LCI. Endoscopic images were reviewed by three experts and three non-experts. Diagnostic accuracy and interobserver agreement were compared among the modalities.

Results For experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (82.7 % vs. 67.0 %; P < 0.001). The diagnostic accuracy of M-Chromo-LCI was not different from M-BLI (87.7 % vs. 82.7 %; P = 0.31). For non-experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (69.3 % vs. 52.3 %; P < 0.001). M-Chromo-LCI additionally showed a significantly higher diagnostic accuracy than M-BLI (79.7 % vs. 69.3 %; P = 0.005). M-Chromo-LCI had the highest interobserver agreement for each group.

Conclusions: M-Chromo-LCI is expected to become a useful modality for the accurate diagnosis of gastric lesions.