Pneumologie 2017; 71(12): 849-919
DOI: 10.1055/s-0043-119504
Leitlinie
© Georg Thieme Verlag KG Stuttgart · New York

S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma

herausgegeben von der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. und der Deutschen Atemwegsliga e.V., unter Beteiligung der Gesellschaft für Pädiatrische Pneumologie e.V. und der Österreichischen Gesellschaft für PneumologieGuideline for the Diagnosis and Treatment of AsthmaGuideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of PneumologyUnter Mitwirkung der folgenden Wissenschaftlichen Fachgesellschaften: Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e. V., Deutsche Gesellschaft für Rehabilitationswissenschaften e.V. und Deutsche Gesellschaft für Gynäkologie und Geburtshilfe e.V.;
R. Buhl
 1   Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Schwerpunkt Pneumologie, III. Medizinische Klinik, Mainz
,
R. Bals
 2   Universitätsklinikum des Saarlandes, Klinik für Innere Medizin V, Homburg/Saar
,
X. Baur
 3   European Society for Environmental and Occupational Medicine, EOM, Berlin
,
D. Berdel
 4   im Ruhestand, Hamminkeln
,
C.-P. Criée
 5   Evangelisches Krankenhaus Göttingen Weende, Abteilung für Pneumologie, Bovenden-Lenglern
,
M. Gappa
 6   Marien-Hospital gGmbH, Klinik für Kinder- und Jugendmedizin, Wesel
,
A. Gillissen
 7   Klinikum Am Steinenberg, Ermstalklinik, Medizinische Klinik III/Innere Medizin und Pneumologie, Reutlingen-Bad Urach
,
T. Greulich
 8   Universitätsklinikum Gießen und Marburg, Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Marburg
,
P. Haidl
 9   Fachkrankenhaus Kloster Grafschaft GmbH, Abteilung Pneumologie II, Schmallenberg
,
E. Hamelmann
10   Evangelisches Klinikum Bethel, Klinik für Kinder- und Jugendmedizin, Bielefeld
,
P. Kardos
11   Lungenpraxis an der Klinik Maingau vom Roten Kreuz, Frankfurt am Main
,
K. Kenn
12   Schön Klinik Berchtesgadener Land, Fachzentrum für Pneumologie, Schönau am Königssee, Philipps Universität Marburg, Standort Schönau
,
L. Klimek
13   Zentrum für Rhinologie und Allergologie, Wiesbaden
,
S. Korn
 1   Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Schwerpunkt Pneumologie, III. Medizinische Klinik, Mainz
,
M. Lommatzsch
14   Universitätsmedizin Rostock, Abteilung Pneumologie, Rostock
,
H. Magnussen
15   Pneumologisches Forschungsinstitut an der LungenClinic Grosshansdorf GmbH, Großhansdorf
,
T. Nicolai
16   Klinikum der Universität München, Kinderklinik und Kinderpoliklinik, LMU München
,
D. Nowak
17   Klinikum der Universität München, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, LMU München
,
O. Pfaar
13   Zentrum für Rhinologie und Allergologie, Wiesbaden
18   HNO-Universitätsklinik Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim
,
K. F. Rabe
19   LungenClinic Grosshansdorf GmbH, Abteilung für Pneumologie, Großhansdorf
,
J. Riedler
20   Kardinal Schwarzenberg Klinikum, Kinder- und Jugendmedizin, Schwarzach im Pongau, Österreich
,
T. Ritz
21   Southern Methodist University, Department of Psychology, Dallas, USA
,
K. Schultz
22   Klinik Bad Reichenhall, Fachbereich Pneumologie, Bad Reichenhall
,
A. Schuster
23   Universitätsklinikum Düsseldorf, Zentrum für Kinder- und Jugendmedizin, Düsseldorf
,
T. Spindler
24   Waldburg-Zeil Kliniken, Fachkliniken Wangen, Klinik für Pädiatrische Pneumologie und Allergologie, Rehabilitationsklinik für Kinder und Jugendliche, Wangen
,
C. Taube
25   Universitätsmedizin Essen, Ruhrlandklinik, Klinik für Pneumologie, Essen
,
K. Taube
26   Atem-Reha GmbH, Hamburg
,
C. Vogelmeier
 8   Universitätsklinikum Gießen und Marburg, Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Marburg
,
A. von Leupoldt
27   University of Leuven, Health Psychology, Leuven, Belgien
,
F. Wantke
28   Floridsdorfer Allergiezentrum, Wien, Österreich
,
S. Weise
29   Atem- und Physiotherapie Solln, München
,
J. Wildhaber
30   HFR Freiburg, Kantonsspital, Klinik für Pädiatrie, Freiburg, Schweiz
,
H. Worth
31   Facharztzentrum Fürth, Fürth
,
A. Zacharasiewicz
32   Wilhelminenspital, Lehrkrankenhaus der Medizinischen Universität Wien, Abteilung für Kinder- und Jugendheilkunde, Wien, Österreich
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
07. Dezember 2017 (online)

Zusammenfassung

Die vorliegende Leitlinie ist eine Neufassung und Aktualisierung der Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma, welche die bisher für den deutschen Sprachraum gültige Version aus dem Jahr 2006 ablöst. Die Fülle an neuen Erkenntnissen zur Pathophysiologie und zu den Phänotypen von Asthma und das erweiterte Spektrum an diagnostischen und therapeutischen Möglichkeiten bei dieser Erkrankung machte eine Neufassung und Aktualisierung notwendig. Es werden sowohl für Kinder und Jugendliche als auch für Erwachsene mit Asthma die aktuellen, Evidenz-basierten diagnostischen und therapeutischen Empfehlungen dargelegt.

Abstract

The present guideline is a new version and an update of the guideline for the diagnosis and treatment of asthma, which replaces the previous version for german speaking countries from the year 2006. The wealth of new data on the pathophysiology and the phenotypes of asthma, and the expanded spectrum of diagnostic and therapeutic options necessitated a new version and an update. This guideline presents the current, evidence-based recommendations for the diagnosis and treatment of asthma, for children and adolescents as well as for adults with asthma.

 
  • Literatur

  • 1 Buhl R, Berdel D, Criée CP. et al. [Guidelines for diagnosis and treatment of asthma patients]. Pneumologie 2006; 60: 139-177
  • 2 Guideline (GINA) Global Initiative for Asthma Management and Prevention. Verfügbar unter www.ginasthma.com
  • 3 www.awmf.org
  • 4 Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 2008; 38: 872-897
  • 5 Holgate ST, Davies DE. Rethinking the pathogenesis of asthma. 2009; 31: 362-367
  • 6 An SS, Bai TR, Bates JH. et al. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 2007; 29: 834-860
  • 7 Wang L, McParland BE, Paré PD. The functional consequences of structural changes in the airways: implications for airway hyperresponsiveness in asthma. Chest 2003; 123: 356S-362S
  • 8 Holgate ST. The airway epithelium is central to the pathogenesis of asthma. Allergol Int 2008; 57: 1-10
  • 9 Holt PG, Sly PD. Environmental Microbial Exposure and Protection against Asthma. N Engl J Med 2015; 373: 2576-2578
  • 10 Holgate ST, Davies DE, Lackie PM. et al. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000; 105: 193-204
  • 11 Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity 2009; 31: 412-424
  • 12 Bratke K, Lommatzsch M, Julius P. et al. Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge. Thorax 2007; 62: 168-175
  • 13 Robinson DS. The role of the T cell in asthma. J Allergy Clin Immunol 2010; 126: 1081-1091
  • 14 Smith SG, Chen R, Kjarsgaard M. et al. Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia. J Allergy Clin Immunol 2016; 137: 75-86 .e8
  • 15 Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol 2015; 16: 45-56
  • 16 Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006; 117: 1277-1284
  • 17 Bochner BS, Gleich GJ. What targeting eosinophils has taught us about their role in diseases. J Allergy Clin Immunol 2010; 126: 16-25
  • 18 Price DB, Rigazio A, Campbell JD. et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med 2015; 3: 849-858
  • 19 Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009; 6: 256-259
  • 20 Kornerup KN, Page CP. The role of platelets in the pathophysiology of asthma. Platelets 2007; 18: 319-328
  • 21 Lommatzsch M, Schloetcke K, Klotz J. et al. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med 2005; 171: 115-120
  • 22 Lommatzsch M, Lindner Y, Edner A. et al. Adverse effects of salmeterol in asthma: a neuronal perspective. Thorax 2009; 64: 763-769
  • 23 Benton AS, Kumar N, Lerner J. et al. Airway platelet activation is associated with airway eosinophilic inflammation in asthma. J Investig Med 2010; 58: 987-990
  • 24 Undem BJ, Carr MJ. The role of nerves in asthma. Curr Allergy Asthma Rep 2002; 2: 159-165
  • 25 Verhein KC, Fryer AD, Jacoby DB. Neural control of airway inflammation. Curr Allergy Asthma Rep 2009; 9: 484-490
  • 26 Fryer AD, Stein LH, Nie Z. et al. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. J Clin Invest 2006; 116: 228-236
  • 27 Zanini A, Chetta A, Imperatori AS. et al. The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. Respir Res 2010; 11: 132
  • 28 Detoraki A, Granata F, Staibano S. et al. Angiogenesis and lymphangiogenesis in bronchial asthma. Allergy 2010; 65: 946-958
  • 29 Murphy DM, OʼByrne PM. Recent advances in the pathophysiology of asthma. Chest 2010; 137: 1417-1426
  • 30 Meyers DA. Genetics of asthma and allergy: what have we learned?. J Allergy Clin Immunol 2010; 126: 439-446
  • 31 Beuther DA. Obesity and asthma. Clin Chest Med 2009; 30: 479-488
  • 32 Thyagarajan B, Jacobs DR, Apostol GG. et al. Longitudinal association of body mass index with lung function: the CARDIA study. Respir Res 2008; 9: 31
  • 33 Haldar P, Pavord ID, Shaw DE. et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218-224
  • 34 Torchio R, Gobbi A, Gulotta C. et al. Mechanical effects of obesity on airway responsiveness in otherwise healthy humans. J Appl Physiol 2009; 107: 408-416
  • 35 Bisgaard H, Bønnelykke K. Long-term studies of the natural history of asthma in childhood. J Allergy Clin Immunol 2010; 126: 187-197
  • 36 Hasler G, Gergen PJ, Kleinbaum DG. et al. Asthma and panic in young adults: a 20-year prospective community study. Am J Respir Crit Care Med 2005; 171: 1224-1230
  • 37 Scott KM, Von Korff M, Alonso J. et al. Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma. Psychosom Med 2008; 70: 1035-1043
  • 38 Chen E, Chim LS, Strunk RC. et al. The role of the social environment in children and adolescents with asthma. Am J Respir Crit Care Med 2007; 176: 644-649
  • 39 Kullowatz A, Rosenfield D, Dahme B. et al. Stress effects on lung function in asthma are mediated by changes in airway inflammation. Psychosom Med 2008; 70: 468-475
  • 40 Ritz T, Kullowatz A, Goldman MD. et al. Airway response to emotional stimuli in asthma: the role of the cholinergic pathway. J Appl Physiol 2010; 108: 1542-1549
  • 41 Liangas G, Morton JR, Henry RL. Mirth-triggered asthma: is laughter really the best medicine?. Pediatr Pulmonol 2003; 36: 107-112
  • 42 Ritz T, Wittchen HU, Klotsche J. et al. Asthma Trigger Reports Are Associated with Low Quality of Life, Exacerbations, and Emergency Treatments. Ann Am Thorac Soc 2016; 13: 204-211
  • 43 Vázquez I, Romero-Frais E, Blanco-Aparicio M. et al. Psychological and self-management factors in near-fatal asthma. J Psychosom Res 2010; 68: 175-181
  • 44 Andersson NW, Hansen MV, Larsen AD. et al. Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies. Allergy 2016; 71: 15-26
  • 45 Sears MR, Greene JM, Willan AR. et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349: 1414-1422
  • 46 Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 2012; 18: 726-735
  • 47 Platts-Mills T, Vaughan J, Squillace S. et al. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001; 357: 752-756
  • 48 Lau S, Illi S, Platts-Mills TA. et al. Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood-report of the German Multicentre Allergy Study (MAS 90). Allergy 2005; 60: 766-773
  • 49 Illi S, von Mutius E, Lau S. et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368: 763-770
  • 50 Deifl S, Bohle B. Factors influencing the allergenicity and adjuvanticity of allergens. Immunotherapy 2011; 3: 881-893
  • 51 Schaub B, Lauener R, von Mutius E. The many faces of the hygiene hypothesis. J Allergy Clin Immunol 2006; 117: 969-977
  • 52 Patel MM, Miller RL. Air pollution and childhood asthma: recent advances and future directions. Curr Opin Pediatr 2009; 21: 235-242
  • 53 Stein MM, Hrusch CL, Gozdz J. et al. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med 2016; 375: 411-421
  • 54 Chatila TA. Innate Immunity in Asthma. N Engl J Med 2016; 375: 477-479
  • 55 von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 2010; 10: 861-868
  • 56 Ege MJ, Mayer M, Normand AC. et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011; 364: 701-709
  • 57 Ball TM, Castro-Rodriguez JA, Griffith KA. et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000; 343: 538-543
  • 58 Bønnelykke K, Vissing NH, Sevelsted A. et al. Association between respiratory infections in early life and later asthma is independent of virus type. J Allergy Clin Immunol 2015; 136: 81-86
  • 59 Jackson DJ, Gangnon RE, Evans MD. et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-672
  • 60 Jackson DJ, Evans MD, Gangnon RE. et al. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med 2012; 185: 281-285
  • 61 Tesse R, Pandey RC, Kabesch M. Genetic variations in toll-like receptor pathway genes influence asthma and atopy. Allergy 2011; 66: 307-316
  • 62 Huang YJ, Nelson CE, Brodie EL. et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011; 127: 372-381
  • 63 Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med 2011; 364: 248-254
  • 64 Sutherland ER, Goleva E, Jackson LP. et al. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med 2010; 181: 699-704
  • 65 Searing DA, Zhang Y, Murphy JR. et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010; 125: 995-1000
  • 66 Ginde AA, Sutherland ER. Vitamin D in asthma: panacea or true promise?. J Allergy Clin Immunol 2010; 126: 59-60
  • 67 Castro M, King TS, Kunselman SJ. et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA 2014; 311: 2083-2091
  • 68 von Mutius E, Martinez FD. Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA 2016; 315: 347-348
  • 69 Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J 2004; 24: 822-833
  • 70 Bateman ED, Boushey HA, Bousquet J. et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 2004; 170: 836-844
  • 71 Chaudhuri R, Livingston E, McMahon AD. et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003; 168: 1308-1311
  • 72 Lazarus SC, Chinchilli VM, Rollings NJ. et al. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 2007; 175: 783-790
  • 73 Chalmers GW, Macleod KJ, Little SA. et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57: 226-230
  • 74 Dezateux C, Stocks J, Dundas I. et al. Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med 1999; 159: 403-410
  • 75 Carlsen KH, Carlsen KC. Respiratory effects of tobacco smoking on infants and young children. Paediatr Respir Rev 2008; 9: 11-19
  • 76 Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 2011; 127: 724-733
  • 77 Ma J, Strub P, Lv N. et al. Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. Eur Respir J 2016; 47: 122-132
  • 78 Willers SM, Devereux G, Craig LC. et al. Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax 2007; 62: 773-779
  • 79 Bisgaard H, Stokholm J, Chawes BL. et al. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med 2016; 375: 2530-2539
  • 80 Duncan JM, Sears MR. Breastfeeding and allergies: time for a change in paradigm?. Curr Opin Allergy Clin Immunol 2008; 8: 398-405
  • 81 Penders J, Kummeling I, Thijs C. Infant antibiotic use and wheeze and asthma risk: a systematic review and meta-analysis. Eur Respir J 2011; 38: 295-302
  • 82 Wickens K, Beasley R, Town I. et al. The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort. Clin Exp Allergy 2011; 41: 399-406
  • 83 Sheehan WJ, Mauger DT, Paul IM. et al. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med 2016; 375: 619-630
  • 84 Kowalski ML, Makowska JS, Blanca M. et al. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) – classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*. Allergy 2011; 66: 818-829
  • 85 Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet 2006; 368: 804-813
  • 86 Agusti A, Bel E, Thomas M. et al. Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J 2016; 47: 410-419
  • 87 Burrows B, Martinez FD, Halonen M. et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320: 271-277
  • 88 Tomassen P, Jarvis D, Newson R. et al. Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study. Allergy 2013; 68: 1289-1297
  • 89 OʼHollaren MT, Yunginger JW, Offord KP. et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 1991; 324: 359-363
  • 90 Harju T, Keistinen T, Tuuponen T. et al. Seasonal variation in childhood asthma hospitalisations in Finland, 1972-1992. Eur J Pediatr 1997; 156: 436-439
  • 91 Mitakakis TZ, Tovey ER, Xuan W. et al. Personal exposure to allergenic pollen and mould spores in inland New South Wales, Australia. Clin Exp Allergy 2000; 30: 1733-1739
  • 92 Bousquet J, Khaltaev N, Cruz AA. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63: 8-160
  • 93 Chipps BE, Zeiger RS, Borish L. et al. Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol 2012; 130: 332-342
  • 94 Lommatzsch M, Korn S, Buhl R. et al. Against all odds: anti-IgE for intrinsic asthma?. Thorax 2014; 69: 94-96
  • 95 Humbert M, Menz G, Ying S. et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20: 528-533
  • 96 Arbes SJ. Do all asthmatics with atopy have atopic asthma?. J Allergy Clin Immunol 2012; 130: 1202-1204
  • 97 Virchow JC, Backer V, Kuna P. et al. Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. JAMA 2016; 315: 1715-1725
  • 98 Ingram JL, Kraft M. IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. J Allergy Clin Immunol 2012; 130: 829-884
  • 99 Gauthier M, Ray A, Wenzel SE. Evolving Concepts of Asthma. Am J Respir Crit Care Med 2015; 192: 660-668
  • 100 Berry M, Morgan A, Shaw DE. et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007; 62: 1043-1049
  • 101 Pavord ID, Korn S, Howarth P. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380: 651-659
  • 102 McGrath KW, Icitovic N, Boushey HA. et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med 2012; 185: 612-619
  • 103 Fleming L, Tsartsali L, Wilson N. et al. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 2012; 67: 675-681
  • 104 Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med 2013; 19: 977-979
  • 105 Hanania NA, Wenzel S, Rosén K. et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013; 187: 804-811
  • 106 Wenzel S, Ford L, Pearlman D. et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013; 368: 2455-2466
  • 107 Katz LE, Gleich GJ, Hartley BF. et al. Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. Ann Am Thorac Soc 2014; 11: 531-536
  • 108 Ortega HG, Liu MC, Pavord ID. et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014; 371: 1198-1207
  • 109 Castro M, Zangrilli J, Wechsler ME. et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med 2015; 3: 355-366
  • 110 Castro M, Wenzel SE, Bleecker ER. et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2014; 2: 879-890
  • 111 Dicpinigaitis PV. Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest 2006; 129: 75S-79S
  • 112 Morice AH, Millqvist E, Belvisi MG. et al. Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. Eur Respir J 2014; 44: 1132-1148
  • 113 Kardos P, Berck H, Fuchs KH. et al. Guidelines of the German Respiratory Society for diagnosis and treatment of adults suffering from acute or chronic cough. Pneumologie 2010; 64: 701-711
  • 114 Rajan JP, Wineinger NE, Stevenson DD. et al. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature. J Allergy Clin Immunol 2015; 135: 676-681
  • 115 Farooque SP, Lee TH. Aspirin-sensitive respiratory disease. Annu Rev Physiol 2009; 71: 465-487
  • 116 Randolph C. An update on exercise-induced bronchoconstriction with and without asthma. Curr Allergy Asthma Rep 2009; 9: 433-438
  • 117 Carlsen KH. The breathless adolescent asthmatic athlete. Eur Respir J 2011; 38: 713-720
  • 118 www.nada.de
  • 119 www.nada.at
  • 120 www.antidoping.ch
  • 121 Lamprecht B, McBurnie MA, Vollmer WM. et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest 2011; 139: 752-763
  • 122 Criée CP, Baur X, Berdel D. et al. [Standardization of spirometry: 2015 update. Published by German Atemwegsliga, German Respiratory Society and German Society of Occupational and Environmental Medicine]. Pneumologie 2015; 69: 147-164
  • 123 Reed CE. Asthma in the elderly: diagnosis and management. J Allergy Clin Immunol 2010; 126: 681-687
  • 124 Fairs A, Agbetile J, Hargadon B. et al. IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med 2010; 182: 1362-1368
  • 125 Knutsen AP, Bush RK, Demain JG. et al. Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol 2012; 129: 280-291
  • 126 Ogawa Y, Calhoun WJ. Phenotypic characterization of severe asthma. Curr Opin Pulm Med 2010; 16: 48-54
  • 127 Lommatzsch M, Virchow JC. Severe asthma: definition, diagnosis and treatment. Dtsch Arztebl Int 2014; 111: 847-855
  • 128 Chung KF, Wenzel SE, Brozek JL. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43: 343-373
  • 129 Sembajwe G, Cifuentes M, Tak SW. et al. National income, self-reported wheezing and asthma diagnosis from the World Health Survey. Eur Respir J 2010; 35: 279-286
  • 130 von Mutius E, Martinez FD, Fritzsch C. et al. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994; 149: 358-364
  • 131 Nowak D, Heinrich J, Jörres R. et al. Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J 1996; 9: 2541-2552
  • 132 Sears MR. Trends in the prevalence of asthma. Chest 2014; 145: 219-225
  • 133 Pearce N, Aït-Khaled N, Beasley R. et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62: 758-766
  • 134 Nowak D, Volmer T, Wettengel R. [Bronchial asthma--a cost of illness analysis]. Pneumologie 1996; 50: 364-371
  • 135 Schramm B, Ehlken B, Smala A. et al. Cost of illness of atopic asthma and seasonal allergic rhinitis in Germany: 1-yr retrospective study. Eur Respir J 2003; 21: 116-122
  • 136 Bousquet J, Jeffery PK, Busse WW. et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000; 161: 1720-1745
  • 137 Kelly HW, Sternberg AL, Lescher R. et al. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 2012; 367: 904-912
  • 138 Suissa S, Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J Allergy Clin Immunol 2001; 107: 937-944
  • 139 Schultze-Werninghaus G. [Asthma mortality in Germany – a critical evaluation]. Pneumologie 2010; 64: 392
  • 140 Brand PL, Baraldi E, Bisgaard H. et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32: 1096-1110
  • 141 Brand PL, Caudri D, Eber E. et al. Classification and pharmacological treatment of preschool wheezing: changes since 2008. Eur Respir J 2014; 43: 1172-1177
  • 142 Gotz M, Eber E, Frischer T. et al. Rezidivierende obstruktive Bronchitis und Asthma bronchiale im Vorschulalter. Konsensuspapier der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde (ÖGKJ) und der Österreichischen Gesellschaft für Pneumologie (ÖGP). Monatsschr Kinderheilkd 2006; 154: 679-684
  • 143 Quanjer PH, Stanojevic S, Cole TJ. et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J 2012; 40: 1324-1343
  • 144 Jenkins C, Seccombe L, Tomlins R. Investigating asthma symptoms in primary care. BMJ 2012; 344: e2734
  • 145 Cockcroft DW, Murdock KY, Berscheid BA. et al. Sensitivity and specificity of histamine PC20 determination in a random selection of young college students. J Allergy Clin Immunol 1992; 89: 23-30
  • 146 Schneider A, Gindner L, Tilemann L. et al. Diagnostic accuracy of spirometry in primary care. BMC Pulm Med 2009; 9: 31
  • 147 O'Byrne PM. Conclusion: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010; 138: 44S-45S
  • 148 Joos GF, O'Connor B, Anderson SD. et al. Indirect airway challenges. Eur Respir J 2003; 21: 1050-1068
  • 149 Criée CP, Sorichter S, Smith HJ. et al. Body plethysmography – its principles and clinical use. Respir Med 2011; 105: 959-971
  • 150 Lex C, Zacharasiewicz A, Schulze J. et al. Bronchiale Provokation im Kindes und Jugendalter. Konsensusstatement der AG Lungenfunktion der Gesellschaft Pädiatrische Pneumologie. Monatsschrift Kinderheilkd 2015; 163: 826-832
  • 151 Moeller A, Carlsen KH, Sly PD. et al. Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation. Eur Respir Rev 2015; 24: 204-215
  • 152 Brzozowska A, Majak P, Grzelewski T. et al. Measurement of specific airway resistance decreased the risk of delay in asthma diagnosis in children. Allergy Asthma Proc 2009; 30: 47-54
  • 153 Magnussen H, Richter K, Taube C. Are chronic obstructive pulmonary disease (COPD) and asthma different diseases?. Clin Exp Allergy 1998; 28: 187-194
  • 154 Reddel HK, Salome CM, Peat JK. et al. Which index of peak expiratory flow is most useful in the management of stable asthma?. Am J Respir Crit Care Med 1995; 151: 1320-1325
  • 155 Petsky HL, Cates CJ, Lasserson TJ. et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax 2012; 67: 199-208
  • 156 Dweik RA, Boggs PB, Erzurum SC. et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011; 184: 602-615
  • 157 Pavord ID, Shaw DE, Gibson PG. et al. Inflammometry to assess airway diseases. Lancet 2008; 372: 1017-1019
  • 158 Porsbjerg C, Baines K, Gibson P. et al. IL-33 is related to innate immune activation and sensitization to HDM in mild steroid-free asthma. Clin Exp Allergy 2016; 46: 564-574
  • 159 Donohue JF, Jain N. Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates. Respir Med 2013; 107: 943-952
  • 160 Pedrosa M, Cancelliere N, Barranco P. et al. Usefulness of exhaled nitric oxide for diagnosing asthma. J Asthma 2010; 47: 817-821
  • 161 Elmasri M, Romero KM, Gilman RH. et al. Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy. Lung 2014; 192: 305-312
  • 162 Karrasch S, Linde K, Rücker G. et al. Accuracy of FENO for diagnosing asthma: a systematic review. Thorax 2017; 72: 109-116
  • 163 Petsky HL, Kew KM, Chang AB. Exhaled nitric oxide levels to guide treatment for children with asthma. Cochrane Database Syst Rev 2016; 11: CD011439
  • 164 Petsky HL, Kew KM, Turner C. et al. Exhaled nitric oxide levels to guide treatment for adults with asthma. Cochrane Database Syst Rev 2016; 9: CD011440
  • 165 Lehtimäki L, Csonka P, Mäkinen E. et al. Predictive value of exhaled nitric oxide in the management of asthma: a systematic review. Eur Respir J 2016; 48: 706-714
  • 166 Pijnenburg MW, Hofhuis W, Hop WC. et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005; 60: 215-218
  • 167 Zacharasiewicz A, Wilson N, Lex C. et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005; 171: 1077-1082
  • 168 McNicholl DM, Stevenson M, McGarvey LP. et al. The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma. Am J Respir Crit Care Med 2012; 186: 1102-1108
  • 169 Powell H, Murphy VE, Taylor DR. et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet 2011; 378: 983-990
  • 170 Höffken G, Lorenz J, Kern W. et al. Guidelines of the Paul-Ehrlich-Society of Chemotherapy, the German Respiratory Diseases Society, the German Infectious Diseases Society and of the Competence Network CAPNETZ for the Management of Lower Respiratory Tract Infections and Community-acquired Pneumonia. Pneumologie 2010; 64: 149-154
  • 171 Graif Y, Yigla M, Tov N. et al. Value of a negative aeroallergen skin-prick test result in the diagnosis of asthma in young adults: correlative study with methacholine challenge testing. Chest 2002; 122: 821-825
  • 172 Chan EY, Dundas I, Bridge PD. et al. Skin-prick testing as a diagnostic aid for childhood asthma. Pediatr Pulmonol 2005; 39: 558-562
  • 173 Melioli G, Passalacqua G, Canonica GW. et al. Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma. Curr Opin Allergy Clin Immunol 2013; 13: 446-451
  • 174 Ollert M, Mari A. In vitro allergy diagnosis – molecules and component-resolved diagnosis. In: Akdis CA. Hrsg. Global Atlas of Allergy. Zurich, Switzerland: European Academy of Allergy and Clinical Immunology; 2014: 168-170
  • 175 Mehl A, Niggemann B, Keil T. et al. Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cowʼs milk and henʼs egg allergy in children: does one replace the other?. Clin Exp Allergy 2012; 42: 1266-1272
  • 176 Ricci G, Capelli M, Miniero R. et al. A comparison of different allergometric tests, skin prick test, Pharmacia UniCAP and ADVIA Centaur, for diagnosis of allergic diseases in children. Allergy 2003; 58: 38-45
  • 177 Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet 2010; 376: 803-813
  • 178 Price DB, Yawn BP, Jones RC. Improving the differential diagnosis of chronic obstructive pulmonary disease in primary care. Mayo Clin Proc 2010; 85: 1122-1129
  • 179 Dima E, Rovina N, Gerassimou C. et al. Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int J Chron Obstruct Pulmon Dis 2010; 5: 287-296
  • 180 Silvestri IC, Pereira CA, Rodrigues SC. Comparison of spirometric changes in the response to bronchodilators of patients with asthma or chronic obstructive pulmonary disease. J Bras Pneumol 2008; 34: 675-682
  • 181 Barnes PJ. Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases. Am J Respir Crit Care Med 2006; 174: 240-243
  • 182 Barnes PJ. Asthma-COPD Overlap. Chest 2016; 149: 7-8
  • 183 http://ginasthma.org/asthma-copd-and-asthma-copd-overlap-syndrome-acos/
  • 184 Barnes NC. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control study. Am J Respir Crit Care Med 2004; 170: 830-831
  • 185 Bateman ED, Buhl R, O'Byrne PM. et al. Predictors of asthma control and a risk score for exacerbations. Am J Respir Crit Care Med 2012; 185: A5667
  • 186 Bateman ED, Reddel HK, Eriksson G. et al. Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol 2010; 125: 600-608
  • 187 van Essen-Zandvliet EE, Hughes MD, Waalkens HJ. et al. Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. The Dutch Chronic Non-specific Lung Disease Study Group. Am Rev Respir Dis 1992; 146: 547-554
  • 188 Haahtela T, Järvinen M, Kava T. et al. Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med 1991; 325: 388-392
  • 189 Kerrebijn KF, van Essen-Zandvliet EE, Neijens HJ. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987; 79: 653-659
  • 190 Barnes PJ, Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma. Report of a workshop held in Eze, France, October 1992. Am Rev Respir Dis 1993; 148: 1-26
  • 191 Djukanović R, Wilson JW, Britten KM. et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992; 145: 669-674
  • 192 Jeffery PK, Godfrey RW, Adelroth E. et al. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 1992; 145: 890-899
  • 193 Gardiner PV, Ward C, Booth H. et al. Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics. Am J Respir Crit Care Med 1994; 150: 1006-1011
  • 194 Laitinen LA, Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol 1992; 90: 32-42
  • 195 Anderson SD, Rozea PJ, Dolton R. et al. Inhaled and oral bronchodilator therapy in exercise induced asthma. Aust N Z J Med 1975; 5: 544-550
  • 196 Shaw RJ, Waller JF, Hetzel MR. et al. Do oral and inhaled terbutaline have different effects on the lung?. Br J Dis Chest 1982; 76: 171-176
  • 197 Powell H, Gibson PG. Initial starting dose of inhaled corticosteroids in adults with asthma: a systematic review. Thorax 2004; 59: 1041-1045
  • 198 Zhang L, Prietsch SO, Ducharme FM. Inhaled corticosteroids in children with persistent asthma: effects on growth. Cochrane Database Syst Rev 2014; 7: CD009471
  • 199 Godfrey S, Bar-Yishay E. Exercised-induced asthma revisited. Respir Med 1993; 87: 331-344
  • 200 Parsons JP, Hallstrand TS, Mastronarde JG. et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2013; 187: 1016-1027
  • 201 Weiler JM, Brannan JD, Randolph CC. et al. Exercise-induced bronchoconstriction update-2016. J Allergy Clin Immunol 2016; 138: 1292-1295 .e36
  • 202 [No authors listed]. Using beta 2-stimulants in asthma. Drug Ther Bull 1997; 35: 1-4
  • 203 OʼByrne PM, Barnes PJ, Rodriguez-Roisin R. et al. Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med 2001; 164: 1392-1397
  • 204 Pauwels RA, Pedersen S, Busse WW. et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 2003; 361: 1071-1076
  • 205 Zeiger RS, Baker JW, Kaplan MS. et al. Variability of symptoms in mild persistent asthma: baseline data from the MIAMI study. Respir Med 2004; 98: 898-905
  • 206 Reddel HK, Busse WW, Pedersen S. et al. Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study. Lancet 2017; 389: 157-166
  • 207 Weinberger M, Hendeles L. Theophylline in asthma. N Engl J Med 1996; 334: 1380-1388
  • 208 Welsh EJ, Cates CJ. Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma. Cochrane Database Syst Rev 2010; 9: CD008418
  • 209 Haahtela T, Järvinen M, Kava T. et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med 1994; 331: 700-705
  • 210 Lazarus SC, Boushey HA, Fahy JV. et al. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001; 285: 2583-2593
  • 211 Lemanske RF, Sorkness CA, Mauger EA. et al. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 2001; 285: 2594-2603
  • 212 Simons FE. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. N Engl J Med 1997; 337: 1659-1665
  • 213 Powell H, Gibson PG. Inhaled corticosteroid doses in asthma: an evidence-based approach. Med J Aust 2003; 178: 223-225
  • 214 Wilson JW, Djukanović R, Howarth PH. et al. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med 1994; 149: 86-90
  • 215 The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000; 343: 1054-1063
  • 216 Adams NP, Bestall JB, Malouf R. et al. Inhaled beclomethasone versus placebo for chronic asthma. Cochrane Database Syst Rev 2005; 1: CD002738
  • 217 Suissa S, Ernst P, Benayoun S. et al. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 2000; 343: 332-336
  • 218 Bisgaard H. A metal aerosol holding chamber devised for young children with asthma. Eur Respir J 1995; 8: 856-860
  • 219 Cates CC, Bara A, Crilly JA. et al. Holding chambers versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev 2003; 3: CD000052
  • 220 Selroos O, Halme M. Effect of a volumatic spacer and mouth rinsing on systemic absorption of inhaled corticosteroids from a metered dose inhaler and dry powder inhaler. Thorax 1991; 46: 891-894
  • 221 Williamson IJ, Matusiewicz SP, Brown PH. et al. Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations. Eur Respir J 1995; 8: 590-592
  • 222 Brown PH, Greening AP, Crompton GK. Large volume spacer devices and the influence of high dose beclomethasone dipropionate on hypothalamo-pituitary-adrenal axis function. Thorax 1993; 48: 233-238
  • 223 Chauhan BF, Ducharme FM. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev 2012; 5: CD002314
  • 224 Lemanske RF, Mauger DT, Sorkness CA. et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med 2010; 362: 975-985
  • 225 Philip G, Nayak AS, Berger WE. et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis. Curr Med Res Opin 2004; 20: 1549-1558
  • 226 Wilson AM, Dempsey OJ, Sims EJ. et al. A comparison of topical budesonide and oral montelukast in seasonal allergic rhinitis and asthma. Clin Exp Allergy 2001; 31: 616-624
  • 227 Bjermer L, Bisgaard H, Bousquet J. et al. Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial. BMJ 2003; 327: 891-895
  • 228 Busse W, Nelson H, Wolfe J. et al. Comparison of inhaled salmeterol and oral zafirlukast in patients with asthma. J Allergy Clin Immunol 1999; 103: 1075-1080
  • 229 Davies B, Brooks G, Devoy M. The efficacy and safety of salmeterol compared to theophylline: meta-analysis of nine controlled studies. Respir Med 1998; 92: 256-263
  • 230 Fish JE, Israel E, Murray JJ. et al. Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy. Chest 2001; 120: 423-430
  • 231 Nelson HS, Busse WW, Kerwin E. et al. Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J Allergy Clin Immunol 2000; 106: 1088-1095
  • 232 Ringdal N, Eliraz A, Pruzinec R. et al. The salmeterol/fluticasone combination is more effective than fluticasone plus oral montelukast in asthma. Respir Med 2003; 97: 234-241
  • 233 Shah L, Wilson AJ, Gibson PG. et al. Long acting beta-agonists versus theophylline for maintenance treatment of asthma. Cochrane Database Syst Rev 2003; 3: CD001281
  • 234 Ni Chroinin M, Greenstone I, Lasserson TJ. et al. Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children. Cochrane Database Syst Rev 2009; 4: CD005307
  • 235 Lazarinis N, Jørgensen L, Ekström T. et al. Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. Thorax 2014; 69: 130-136
  • 236 American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med 2007; 175: 235-242
  • 237 Dahl R, Larsen BB, Venge P. Effect of long-term treatment with inhaled budesonide or theophylline on lung function, airway reactivity and asthma symptoms. Respir Med 2002; 96: 432-438
  • 238 Evans DJ, Taylor DA, Zetterstrom O. et al. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med 1997; 337: 1412-1418
  • 239 Lim S, Jatakanon A, Gordon D. et al. Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax 2000; 55: 837-841
  • 240 Reed CE, Offord KP, Nelson HS. et al. Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma. The American Academy of Allergy, Asthma and Immunology Beclomethasone Dipropionate-Theophylline Study Group. J Allergy Clin Immunol 1998; 101: 14-23
  • 241 Rivington RN, Boulet LP, Côté J. et al. Efficacy of Uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids. Am J Respir Crit Care Med 1995; 151: 325-332
  • 242 Tinkelman DG, Reed CE, Nelson HS. et al. Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993; 92: 64-77
  • 243 Ukena D, Harnest U, Sakalauskas R. et al. Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. Eur Respir J 1997; 10: 2754-2760
  • 244 Tsiu SJ, Self TH, Burns R. Theophylline toxicity: update. Ann Allergy 1990; 64: 241-257
  • 245 Guevara JP, Ducharme FM, Keren R. et al. Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma. Cochrane Database Syst Rev 2006; 2: CD003558
  • 246 Sridhar AV, McKean M. Nedocromil sodium for chronic asthma in children. Cochrane Database Syst Rev 2006; 3: CD004108
  • 247 Ducharme FM, Ni Chroinin M, Greenstone I. et al. Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. Cochrane Database Syst Rev 2010; 5: CD005535
  • 248 Kesten S, Chapman KR, Broder I. et al. A three-month comparison of twice daily inhaled formoterol versus four times daily inhaled albuterol in the management of stable asthma. Am Rev Respir Dis 1991; 144: 622-625
  • 249 Pauwels RA, Löfdahl CG, Postma DS. et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 1997; 337: 1405-1411
  • 250 Pearlman DS, Chervinsky P, LaForce C. et al. A comparison of salmeterol with albuterol in the treatment of mild-to-moderate asthma. N Engl J Med 1992; 327: 1420-1425
  • 251 Shrewsbury S, Pyke S, Britton M. Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ 2000; 320: 1368-1373
  • 252 Wenzel SE, Lumry W, Manning M. et al. Efficacy, safety, and effects on quality of life of salmeterol versus albuterol in patients with mild to moderate persistent asthma. Ann Allergy Asthma Immunol 1998; 80: 463-470
  • 253 Bateman ED, Harrison TW, Quirce S. et al. Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Respir Res 2011; 12: 38
  • 254 Cates CJ, Karner C. Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children. Cochrane Database Syst Rev 2013; 4: CD007313
  • 255 Kew KM, Karner C, Mindus SM. et al. Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev 2013; 12: CD009019
  • 256 Papi A, Corradi M, Pigeon-Francisco C. et al. Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial. Lancet Respir Med 2013; 1: 23-31
  • 257 Patel M, Pilcher J, Pritchard A. et al. Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Lancet Respir Med 2013; 1: 32-42
  • 258 Aubier M, Pieters WR, Schlösser NJ. et al. Salmeterol/fluticasone propionate (50/500 microg) in combination in a Diskus inhaler (Seretide) is effective and safe in the treatment of steroid-dependent asthma. Respir Med 1999; 93: 876-884
  • 259 Bateman E. Salmeterol/Fluticasone Propionate Combination. Drugs 1999; 57: 941-943
  • 260 Chapman KR, Ringdal N, Backer V. et al. Salmeterol and fluticasone propionate (50/250 microg) administered via combination Diskus inhaler: as effective as when given via separate Diskus inhalers. Can Respir J 1999; 6: 45-51
  • 261 Nelson HS, Chapman KR, Pyke SD. et al. Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers. J Allergy Clin Immunol 2003; 112: 29-36
  • 262 Van den Berg NJ, Ossip MS, Hederos CA. et al. Salmeterol/fluticasone propionate (50/100 microg) in combination in a Diskus inhaler (Seretide) is effective and safe in children with asthma. Pediatr Pulmonol 2000; 30: 97-105
  • 263 Zetterström O, Buhl R, Mellem H. et al. Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone. Eur Respir J 2001; 18: 262-268
  • 264 Turner S, Richardson K, Murray C. et al. Long-Acting β-Agonist in Combination or Separate Inhaler as Step-Up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids. J Allergy Clin Immunol Pract 2017; 5: 99-106 .e3
  • 265 Ducharme FM, Ni Chroinin M, Greenstone I. et al. Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma. Cochrane Database Syst Rev 2010; 4: CD005533
  • 266 Szefler SJ, Martin RJ, King TS. et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002; 109: 410-418
  • 267 Greening AP, Ind PW, Northfield M. et al. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Lancet 1994; 344: 219-224
  • 268 Woolcock A, Lundback B, Ringdal N. et al. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996; 153: 1481-1488
  • 269 Busse WW, Chervinsky P, Condemi J. et al. Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma. J Allergy Clin Immunol 1998; 101: 457-463
  • 270 Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Intern Med 1999; 159: 941-955
  • 271 Chauhan BF, Ducharme FM. Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma. Cochrane Database Syst Rev 2014; 1: CD003137
  • 272 Laviolette M, Malmstrom K, Lu S. et al. Montelukast added to inhaled beclomethasone in treatment of asthma. Montelukast/Beclomethasone Additivity Group. Am J Respir Crit Care Med 1999; 160: 1862-1868
  • 273 Price DB, Hernandez D, Magyar P. et al. Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma. Thorax 2003; 58: 211-216
  • 274 Vaquerizo MJ, Casan P, Castillo J. et al. Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma. Thorax 2003; 58: 204-210
  • 275 Virchow JC, Prasse A, Naya I. et al. Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids. Am J Respir Crit Care Med 2000; 162: 578-585
  • 276 Crompton GK, Ayres JG, Basran G. et al. Comparison of oral bambuterol and inhaled salmeterol in patients with symptomatic asthma and using inhaled corticosteroids. Am J Respir Crit Care Med 1999; 159: 824-828
  • 277 Persson G, Baas A, Knight A. et al. One month treatment with the once daily oral beta 2-agonist bambuterol in asthmatic patients. Eur Respir J 1995; 8: 34-39
  • 278 Wallaert B, Brun P, Ostinelli J. et al. A comparison of two long-acting beta-agonists, oral bambuterol and inhaled salmeterol, in the treatment of moderate to severe asthmatic patients with nocturnal symptoms. The French Bambuterol Study Group. Respir Med 1999; 93: 33-38
  • 279 Murray CS, Thomas M, Richardson K. et al. Comparative Effectiveness of Step-up Therapies in Children with Asthma Prescribed Inhaled Corticosteroids: A Historical Cohort Study. J Allergy Clin Immunol Pract 2017; 5: 1082-1090
  • 280 OʼByrne PM, Naya IP, Kallen A. et al. Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control. Chest 2008; 134: 1192-1199
  • 281 Kerstjens HA, Disse B, Schröder-Babo W. et al. Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol 2011; 128: 308-314
  • 282 Kerstjens HA, Engel M, Dahl R. et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med 2012; 367: 1198-1207
  • 283 Peters SP, Kunselman SJ, Icitovic N. et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 2010; 363: 1715-1726
  • 284 Hamelmann E, Bateman ED, Vogelberg C. et al. Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial. J Allergy Clin Immunol 2016; 138: 441-450
  • 285 Vogelberg C, Moroni-Zentgraf P, Leonaviciute-Klimantaviciene M. et al. A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids. Respir Res 2015; 16: 20
  • 286 Vogelberg C, Engel M, Moroni-Zentgraf P. et al. Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: a randomised dose-ranging study. Respir Med 2014; 108: 1268-1276
  • 287 Ni Chroinin M, Lasserson TJ, Greenstone I. et al. Addition of long-acting beta-agonists to inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev 2009; 3: CD007949
  • 288 Malo JL, Cartier A, Ghezzo H. et al. Comparison of four-times-a-day and twice-a-day dosing regimens in subjects requiring 1200 micrograms or less of budesonide to control mild to moderate asthma. Respir Med 1995; 89: 537-543
  • 289 Toogood JH, Baskerville JC, Jennings B. et al. Influence of dosing frequency and schedule on the response of chronic asthmatics to the aerosol steroid, budesonide. J Allergy Clin Immunol 1982; 70: 288-298
  • 290 Löfdahl CG, Reiss TF, Leff JA. et al. Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients. BMJ 1999; 319: 87-90
  • 291 Tamaoki J, Kondo M, Sakai N. et al. Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. The Tokyo Joshi-Idai Asthma Research Group. Am J Respir Crit Care Med 1997; 155: 1235-1240
  • 292 Normansell R, Walker S, Milan SJ. et al. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev 2014; 1: CD003559
  • 293 Garcia G, Magnan A, Chiron R. et al. A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. Chest 2013; 144: 411-419
  • 294 Bel EH, Wenzel SE, Thompson PJ. et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 2014; 371: 1189-1197
  • 295 Bjermer L, Lemiere C, Maspero J. et al. Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study. Chest 2016; 150: 789-798
  • 296 Corren J, Weinstein S, Janka L. et al. Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts. Chest 2016; 150: 799-810
  • 297 Harrison BD, Stokes TC, Hart GJ. et al. Need for intravenous hydrocortisone in addition to oral prednisolone in patients admitted to hospital with severe asthma without ventilatory failure. Lancet 1986; 1: 181-184
  • 298 OʼDriscoll BR, Kalra S, Wilson M. et al. Double-blind trial of steroid tapering in acute asthma. Lancet 1993; 341: 324-327
  • 299 Walsh LJ, Wong CA, Oborne J. et al. Adverse effects of oral corticosteroids in relation to dose in patients with lung disease. Thorax 2001; 56: 279-284
  • 300 Dunlap NE, Fulmer JD. Corticosteroid therapy in asthma. Clin Chest Med 1984; 5: 669-683
  • 301 Mash B, Bheekie A, Jones PW. Inhaled vs oral steroids for adults with chronic asthma. Cochrane Database Syst Rev 2001; 1: CD002160
  • 302 American College of Rheumatology Task Force on Osteoporosis Guidelines. Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Rheum 1996; 39: 1791-1801
  • 303 Eastell R, Reid DM, Compston J. et al. A UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update. J Intern Med 1998; 244: 271-292
  • 304 Vogelmeier C, Kardos P, Hofmann T. et al. Nebulised budesonide using a novel device in patients with oral steroid-dependent asthma. Eur Respir J 2015; 45: 1273-1282
  • 305 Hill JM. Nebulised corticosteroids in the treatment of patients with asthma. Thorax 1999; 54: 661-663
  • 306 Otulana BA, Varma N, Bullock A. et al. High dose nebulized steroid in the treatment of chronic steroid-dependent asthma. Respir Med 1992; 86: 105-108
  • 307 Davies H, Olson L, Gibson P. Methotrexate as a steroid sparing agent for asthma in adults. Cochrane Database Syst Rev 2000; 2: CD000391
  • 308 Hill JM, Tattersfield AE. Corticosteroid sparing agents in asthma. Thorax 1995; 50: 577-582
  • 309 Aaron SD, Dales RE, Pham B. Management of steroid-dependent asthma with methotrexate: a meta-analysis of randomized clinical trials. Respir Med 1998; 92: 1059-1065
  • 310 Marin MG. Low-dose methotrexate spares steroid usage in steroid-dependent asthmatic patients: a meta-analysis. Chest 1997; 112: 29-33
  • 311 Menz G, Buhl R, Gillissen A. et al. Schwieriges Asthma: Klinische Phänotypen und Prinzipien der Therapie. Pneumologie 2002; 56: 132-137
  • 312 Pfaar O, Bachert C, Bufe A. et al. Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 2014; 23: 282-319
  • 313 Mosbech H, Deckelmann R, de Blay F. et al. Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2014; 134: 568-575
  • 314 Abramson MJ, Puy RM, Weiner JM. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev 2010; 8: CD001186
  • 315 Calderon MA, Casale TB, Nelson HS. et al. An evidence-based analysis of house dust mite allergen immunotherapy: a call for more rigorous clinical studies. J Allergy Clin Immunol 2013; 132: 1322-1336
  • 316 Zielen S, Kardos P, Madonini E. Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial. J Allergy Clin Immunol 2010; 126: 942-949
  • 317 Jacobsen L, Niggemann B, Dreborg S. et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 2007; 62: 943-948
  • 318 Bufe A, Eberle P, Franke-Beckmann E. et al. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy. J Allergy Clin Immunol 2009; 123: 167-173
  • 319 Bousquet J, Scheinmann P, Guinnepain MT. et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 1999; 54: 249-260
  • 320 Pajno GB, Morabito L, Barberio G. et al. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy 2000; 55: 842-849
  • 321 Valovirta E, Berstad AK, de Blic J. et al. Design and recruitment for the GAP trial, investigating the preventive effect on asthma development of an SQ-standardized grass allergy immunotherapy tablet in children with grass pollen-induced allergic rhinoconjunctivitis. Clin Ther 2011; 33: 1537-1546
  • 322 http://www.dgaki.de/leitlinien/s2k-leitlinie-sit/sit-produkte-studien-zulassung/
  • 323 http://www.atemwegsliga.de/
  • 324 Knipel V, Criée CP, Windisch W. [Correct inhalation therapy: instructions provided by Internet-based video screens. An initiative of the German Airway League]. Pneumologie 2013; 67: 157-161
  • 325 Dekhuijzen PN, Vincken W, Virchow JC. et al. Prescription of inhalers in asthma and COPD: towards a rational, rapid and effective approach. Respir Med 2013; 107: 1817-1821
  • 326 Lavorini F. Inhaled drug delivery in the hands of the patient. J Aerosol Med Pulm Drug Deliv 2014; 27: 414-418
  • 327 Scichilone N. Asthma control: the right inhaler for the right patient. Adv Ther 2015; 32: 285-292
  • 328 Laube BL, Janssens HM, de Jongh FH. et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J 2011; 37: 1308-1331
  • 329 Bosnic-Anticevich SZ, Sinha H, So S. et al. Metered-dose inhaler technique: the effect of two educational interventions delivered in community pharmacy over time. J Asthma 2010; 47: 251-256
  • 330 van der Meer V, van Stel HF, Bakker MJ. et al. Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study. Respir Res 2010; 11: 74
  • 331 Bjermer L. The importance of continuity in inhaler device choice for asthma and chronic obstructive pulmonary disease. Respiration 2014; 88: 346-352
  • 332 Thomas M, Price D, Chrystyn H. et al. Inhaled corticosteroids for asthma: impact of practice level device switching on asthma control. BMC Pulm Med 2009; 9: 1
  • 333 Leach CL, Colice GL. A pilot study to assess lung deposition of HFA-beclomethasone and CFC-beclomethasone from a pressurized metered dose inhaler with and without add-on spacers and using varying breathhold times. J Aerosol Med Pulm Drug Deliv 2010; 23: 355-361
  • 334 Nair A, Menzies D, Hopkinson P. et al. In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhaler. Br J Clin Pharmacol 2009; 67: 191-198
  • 335 Small M, Anderson P, Vickers A. et al. Importance of inhaler-device satisfaction in asthma treatment: real-world observations of physician-observed compliance and clinical/patient-reported outcomes. Adv Ther 2011; 28: 202-212
  • 336 Williams LK, Peterson EL, Wells K. et al. A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma. J Allergy Clin Immunol 2010; 126: 225-231
  • 337 Mehuys E, Van Bortel L, De Bolle L. et al. Effectiveness of pharmacist intervention for asthma control improvement. Eur Respir J 2008; 31: 790-799
  • 338 Papi A, Canonica GW, Maestrelli P. et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. N Engl J Med 2007; 356: 2040-2052
  • 339 Martin AR, Finlay WH. Nebulizers for drug delivery to the lungs. Expert Opin Drug Deliv 2015; 12: 889-900
  • 340 Hess DR. The mask for noninvasive ventilation: principles of design and effects on aerosol delivery. J Aerosol Med 2007; 20: S85-S99
  • 341 Dhand R. Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv 2008; 21: 45-60
  • 342 Ditcham W, Murdzoska J, Zhang G. et al. Lung deposition of 99mTc-radiolabeled albuterol delivered through a pressurized metered dose inhaler and spacer with facemask or mouthpiece in children with asthma. J Aerosol Med Pulm Drug Deliv 2014; 27: S63-S75
  • 343 Gibson PG, Powell H. Written action plans for asthma: an evidence-based review of the key components. Thorax 2004; 59: 94-99
  • 344 Rodrigo GJ, Castro-Rodriguez JA. Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax 2005; 60: 740-746
  • 345 Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev 2013; 9: CD000052
  • 346 Silverman RA, Osborn H, Runge J. et al. IV magnesium sulfate in the treatment of acute severe asthma: a multicenter randomized controlled trial. Chest 2002; 122: 489-497
  • 347 Browne GJ, Penna AS, Phung X. et al. Randomised trial of intravenous salbutamol in early management of acute severe asthma in children. Lancet 1997; 349: 301-305
  • 348 Papo MC, Frank J, Thompson AE. A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children. Crit Care Med 1993; 21: 1479-1486
  • 349 Craven D, Kercsmar CM, Myers TR. et al. Ipratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma. J Pediatr 2001; 138: 51-58
  • 350 Bhogal SK, McGillivray D, Bourbeau J. et al. Early administration of systemic corticosteroids reduces hospital admission rates for children with moderate and severe asthma exacerbation. Ann Emerg Med 2012; 60: 84-91
  • 351 Ream RS, Loftis LL, Albers GM. et al. Efficacy of IV theophylline in children with severe status asthmaticus. Chest 2001; 119: 1480-1488
  • 352 Wheeler DS, Jacobs BR, Kenreigh CA. et al. Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial. Pediatr Crit Care Med 2005; 6: 142-147
  • 353 Pabon H, Monem G, Kissoon N. Safety and efficacy of magnesium sulfate infusions in children with status asthmaticus. Pediatr Emerg Care 1994; 10: 200-203
  • 354 Markovitz B. Does magnesium sulphate have a role in the management of paediatric status asthmaticus?. Arch Dis Child 2002; 86: 381-382
  • 355 Hartling L, Fernandes RM, Bialy L. et al. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis. BMJ 2011; 342: d1714
  • 356 Andrews T, McGintee E, Mittal MK. et al. High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. J Pediatr 2009; 155: 205-210
  • 357 Craig VL, Bigos D, Brilli RJ. Efficacy and safety of continuous albuterol nebulization in children with severe status asthmaticus. Pediatr Emerg Care 1996; 12: 1-5
  • 358 Stephanopoulos DE, Monge R, Schell KH. et al. Continuous intravenous terbutaline for pediatric status asthmaticus. Crit Care Med 1998; 26: 1744-1748
  • 359 Kim IK, Phrampus E, Venkataraman S. et al. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics 2005; 116: 1127-1133
  • 360 Nievas IF, Anand KJ. Severe acute asthma exacerbation in children: a stepwise approach for escalating therapy in a pediatric intensive care unit. J Pediatr Pharmacol Ther 2013; 18: 88-104
  • 361 Brenner B, Corbridge T, Kazzi A. Intubation and mechanical ventilation of the asthmatic patient in respiratory failure. Proc Am Thorac Soc 2009; 6: 371-379
  • 362 Moore WC, Evans MD, Bleecker ER. et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol 2011; 128: 328-336
  • 363 Good JT, Kolakowski CA, Groshong SD. et al. Refractory asthma: importance of bronchoscopy to identify phenotypes and direct therapy. Chest 2012; 141: 599-606
  • 364 Scala R. Noninvasive ventilation in severe acute asthma? Still far from the truth. Respir Care 2010; 55: 630-637
  • 365 Soroksky A, Klinowski E, Ilgyev E. et al. Noninvasive positive pressure ventilation in acute asthmatic attack. Eur Respir Rev 2010; 19: 39-45
  • 366 Westhoff M, Schönhofer B, Neumann P. et al. [Noninvasive Mechanical Ventilation in Acute Respiratory Failure]. Pneumologie 2015; 69: 719-756
  • 367 Nowak R, Corbridge T, Brenner B. Noninvasive ventilation. Proc Am Thorac Soc 2009; 6: 367-370
  • 368 Schönhofer B, Kuhlen R, Neumann P. et al. [Non-invasive mechanical ventilation in acute respiratory failure]. Pneumologie 2008; 62: 449-479
  • 369 Basnet S, Mander G, Andoh J. et al. Safety, efficacy, and tolerability of early initiation of noninvasive positive pressure ventilation in pediatric patients admitted with status asthmaticus: a pilot study. Pediatr Crit Care Med 2012; 13: 393-398
  • 370 Carroll CL, Schramm CM. Noninvasive positive pressure ventilation for the treatment of status asthmaticus in children. Ann Allergy Asthma Immunol 2006; 96: 454-459
  • 371 Mayordomo-Colunga J, Medina A, Rey C. et al. Non-invasive ventilation in pediatric status asthmaticus: a prospective observational study. Pediatr Pulmonol 2011; 46: 949-955
  • 372 Akingbola OA, Simakajornboon N, Hadley Jr EF. et al. Noninvasive positive-pressure ventilation in pediatric status asthmaticus. Pediatr Crit Care Med 2002; 3: 181-184
  • 373 Venkataraman ST. Mechanical ventilation and respiratory care. In: Fuhrman BP, Zimmerman JJ. (Eds). Pediatric critical care. Philadelphia: Mosby; 2006
  • 374 Sodhi C, Singh S, Dandona PK. A study of the effect of yoga training on pulmonary functions in patients with bronchial asthma. Indian J Physiol Pharmacol 2009; 53: 169-174
  • 375 Holloway E, Ram FS. Breathing exercises for asthma. Cochrane Database Syst Rev 2004; 1: CD001277
  • 376 Holloway EA, West RJ. Integrated breathing and relaxation training (the Papworth method) for adults with asthma in primary care: a randomised controlled trial. Thorax 2007; 62: 1039-1042
  • 377 Shaw BS, Shaw I. Pulmonary function and abdominal and thoracic kinematic changes following aerobic and inspiratory resistive diaphragmatic breathing training in asthmatics. Lung 2011; 189: 131-139
  • 378 Freitas DA, Holloway EA, Bruno SS. et al. Breathing exercises for adults with asthma. Cochrane Database Syst Rev 2013; 10: CD001277
  • 379 Ritz T, Rosenfield D, Steele AM. et al. Controlling asthma by training of Capnometry-Assisted Hypoventilation (CATCH) vs slow breathing: a randomized controlled trial. Chest 2014; 146: 1237-1247
  • 380 Barker NJ, Jones M, OʼConnell NE. et al. Breathing exercises for dysfunctional breathing/hyperventilation syndrome in children. Cochrane Database Syst Rev 2013; 12: CD010376
  • 381 Lehrer PM, Vaschillo E, Vaschillo B. et al. Biofeedback treatment for asthma. Chest 2004; 126: 352-361
  • 382 Thomas M, McKinley RK, Mellor S. et al. Breathing exercises for asthma: a randomised controlled trial. Thorax 2009; 64: 55-61
  • 383 Chiang LC, Ma WF, Huang JL. et al. Effect of relaxation-breathing training on anxiety and asthma signs/symptoms of children with moderate-to-severe asthma: a randomized controlled trial. Int J Nurs Stud 2009; 46: 1061-1070
  • 384 Blackhall K, Appleton S, Cates CJ. Ionisers for chronic asthma. Cochrane Database Syst Rev 2003; 3: CD002986
  • 385 Warner JA, Marchant JL, Warner JO. Double blind trial of ionisers in children with asthma sensitive to the house dust mite. Thorax 1993; 48: 330-333
  • 386 Nogrady SG, Furnass SB. Ionisers in the management of bronchial asthma. Thorax 1983; 38: 919-922
  • 387 Yang ZY, Zhong HB, Mao C. et al. Yoga for asthma. Cochrane Database Syst Rev 2016; 4: CD010346
  • 388 Huntley A, White AR, Ernst E. Relaxation therapies for asthma: a systematic review. Thorax 2002; 57: 127-131
  • 389 Yorke J, Fleming S, Shuldham C. et al. Nonpharmacological interventions aimed at modifying health and behavioural outcomes for adults with asthma: a critical review. Clin Exp Allergy 2015; 45: 1750-1764
  • 390 Ritz T, Meuret AE, Trueba AF. et al. Psychosocial factors and behavioral medicine interventions in asthma. J Consult Clin Psychol 2013; 81: 231-250
  • 391 Boyle RJ, Pedroletti C, Wickman M. et al. Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial. Thorax 2012; 67: 215-221
  • 392 Pedroletti C, Millinger E, Dahlén B. et al. Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial. Respir Med 2009; 103: 1313-1319
  • 393 British Thoracic Society; Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. A national clinical guideline. Verfügbar unter http://www.brit-thoracic.org.uk 2016
  • 394 Lingner H, Ernst S, Groβhennig A. et al. Asthma control and health-related quality of life one year after inpatient pulmonary rehabilitation: the ProKAR Study. J Asthma 2015; 52: 614-621
  • 395 Farin E, Opitz U, Jäckel WH. et al. Pneumologische Rehabilitation: Langzeitdaten zur Lebensqualität und Prädiktoren der Behandlungseffekte. Phys Med Rehab Kuror 2009; 19: 75-84
  • 396 Schmidt J, Kaiser U, Kriz D. et al. Die Davoser Outcome-Studie (DOS) – Ergebnisse stationärer pneumologischer und dermatologischer Heilbehandlungen im Spiegel wiederholter Nacherhebungen. Prävention und Rehabilitation 2014; 26: 119-140
  • 397 Schultz K, Seidl H, Jelusic D. et al. Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA). BMC Pulm Med 2017; 17: 49
  • 398 de Vries U. Asthma – Patientenschulung im Rahmen ambulanter und stationärer Rehabilitation. Regensburg: Roderer Verlag; 2004
  • 399 Nici L, Donner C, Wouters E. et al. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med 2006; 173: 1390-1413
  • 400 British Thoracic Society Standards of Care Subcommittee on Pulmonary Rehabilitation. Pulmonary rehabilitation. Thorax 2001; 56: 827-834
  • 401 Ries AL, Bauldoff GS, Carlin BW. et al. Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines. Chest 2007; 131: 4S-42S
  • 402 Bergmann KC, Fischer J, Schmitz M. et al. [Inpatient pneumologic rehabilitation of adults: goals--diagnostic and therapeutic standards-research needs]. Pneumologie 1997; 51: 523-532
  • 403 World Health Organisation. (Hrsg). International Classification of Functioning, Disability and Health (ICF). 2001
  • 404 Fischer J, Raschke F. [Goal-oriented measurement of short-, medium- and long-term effects in pneumological rehabilitation]. Pneumologie 2000; 54: 458-463
  • 405 Worth H, Petro W. [Recommendations for structure and contents of train-the-trainer seminars for educating patients with chronic obstructive respiratory tract diseases]. Pneumologie 1998; 52: 473-474
  • 406 Spindler T, Rank M, Otto J. Veränderte psychosoziale Rahmenbedingungen erfordern Umdenken in der Rehabilitation. Kinder- und Jugendmedizin 2001; 5: 35-38
  • 407 Szczepanski R, Jaeschke R, Spindler T. et al. Preschoolers' and parents' asthma education trial (P2AET)-a randomized controlled study. Eur J Pediatr 2010; 169: 1051-1060
  • 408 Spindler T, Lob-Corzilius T. Qualitätmanagement in der Asthmaschulung von Kindern und Jugendlichen. 4. Auflage Wangen im Allgäu: iKuh-Verlag; 2013
  • 409 Bauer CP, Petermann F, Kiosz D. et al. [Long-term effect of indoor rehabilitation on children and young people with moderate and severe asthma]. Pneumologie 2002; 56: 478-485
  • 410 Emtner M, Finne M, Stålenheim G. A 3-year follow-up of asthmatic patients participating in a 10-week rehabilitation program with emphasis on physical training. Arch Phys Med Rehabil 1998; 79: 539-544
  • 411 Petermann F, Gulyas A, Niebank K. et al. Rehabilitationserfolg bei Kindern und Jugendlichen mit Asthma und Neurodermitis. Allergologie 2000; 23: 492-502
  • 412 Warschburger P, Busch S, Bauer CP. et al. Health-related quality of life in children and adolescents with asthma: results from the ESTAR Study. J Asthma 2004; 41: 463-470
  • 413 Cambach W, Wagenaar RC, Koelman TW. et al. The long-term effects of pulmonary rehabilitation in patients with asthma and chronic obstructive pulmonary disease: a research synthesis. Arch Phys Med Rehabil 1999; 80: 103-111
  • 414 Cambach W, Chadwick-Straver RV, Wagenaar RC. et al. The effects of a community-based pulmonary rehabilitation programme on exercise tolerance and quality of life: a randomized controlled trial. Eur Respir J 1997; 10: 104-113
  • 415 Foglio K, Bianchi L, Bruletti G. et al. Long-term effectiveness of pulmonary rehabilitation in patients with chronic airway obstruction. Eur Respir J 1999; 13: 125-132
  • 416 www.asthmaschulung.de
  • 417 Gibson PG, Powell H, Coughlan J. et al. Self-management education and regular practitioner review for adults with asthma. Cochrane Database Syst Rev 2003; 1: CD001117
  • 418 Gibson PG, Powell H, Coughlan J. et al. Limited (information only) patient education programs for adults with asthma. Cochrane Database Syst Rev 2002; 2: CD001005
  • 419 Schacher C, Dhein Y, Münks-Lederer C. et al. [Evaluation of a structured outpatient education program for adult asthmatics]. Dtsch Med Wochenschr 2006; 131: 606-610
  • 420 Powell H, Gibson PG. Options for self-management education for adults with asthma. Cochrane Database Syst Rev 2003; 1: CD004107
  • 421 Petro W, Wettengel R, Worth H. Empfehlungen zum strukturierten Patiententraining bei obstruktiven Atemwegserkrankungen. Med Klin 1995; 90: 515-519
  • 422 Carson KV, Chandratilleke MG, Picot J. et al. Physical training for asthma. Cochrane Database Syst Rev 2013; 9: CD001116
  • 423 Emtner M, Herala M, Stålenheim G. High-intensity physical training in adults with asthma. A 10-week rehabilitation program. Chest 1996; 109: 323-330
  • 424 Mendes FA, Gonçalves RC, Nunes MP. et al. Effects of aerobic training on psychosocial morbidity and symptoms in patients with asthma: a randomized clinical trial. Chest 2010; 138: 331-337
  • 425 Turner S, Eastwood P, Cook A. et al. Improvements in symptoms and quality of life following exercise training in older adults with moderate/severe persistent asthma. Respiration 2011; 81: 302-310
  • 426 Dogra S, Kuk JL, Baker J. et al. Exercise is associated with improved asthma control in adults. Eur Respir J 2011; 37: 318-323
  • 427 Beggs S, Foong YC, Le HC. et al. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database Syst Rev 2013; 4: CD009607
  • 428 Worth H, Meyer A, Folgering H. et al. [Recommendations of the German Respiratory League on sports and physical training for patients with obstructive respiratory tract diseases]. Pneumologie 2000; 54: 61-67
  • 429 Siroux V, Pin I, Oryszczyn MP. et al. Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma. Eur Respir J 2000; 15: 470-477
  • 430 Ehrlich RI, Du Toit D, Jordaan E. et al. Risk factors for childhood asthma and wheezing. Importance of maternal and household smoking. Am J Respir Crit Care Med 1996; 154: 681-688
  • 431 Chaudhuri R, Livingston E, McMahon AD. et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med 2006; 174: 127-133
  • 432 Rayens MK, Burkhart PV, Zhang M. et al. Reduction in asthma-related emergency department visits after implementation of a smoke-free law. J Allergy Clin Immunol 2008; 122: 537-541 .e3
  • 433 Andreas S, Batra A, Behr J. et al. [Guidelines for smoking cessation in patients with COPD issued by the Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin]. Pneumologie 2008; 62: 255-272
  • 434 Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 2007; 101: 2240-2247
  • 435 Lavoie KL, Bacon SL, Labrecque M. et al. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med 2006; 100: 648-657
  • 436 Saint-Pierre P, Bourdin A, Chanez P. et al. Are overweight asthmatics more difficult to control?. Allergy 2006; 61: 79-84
  • 437 Sutherland ER, Goleva E, Strand M. et al. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008; 178: 682-687
  • 438 Adeniyi FB, Young T. Weight loss interventions for chronic asthma. Cochrane Database Syst Rev 2012; 7: CD009339
  • 439 Moreira A, Bonini M, Garcia-Larsen V. et al. Weight loss interventions in asthma: EAACI evidence-based clinical practice guideline (part I). Allergy 2013; 68: 425-439
  • 440 Boulet LP, Turcotte H, Martin J. et al. Effect of bariatric surgery on airway response and lung function in obese subjects with asthma. Respir Med 2012; 106: 651-660
  • 441 Dixon AE, Pratley RE, Forgione PM. et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol 2011; 128: 508-515
  • 442 Scott HA, Gibson PG, Garg ML. et al. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin Exp Allergy 2013; 43: 36-49
  • 443 Castro M, Rubin AS, Laviolette M. et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 2010; 181: 116-124
  • 444 Thomson NC, Rubin AS, Niven RM. et al. Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med 2011; 11: 8
  • 445 Cox G, Thomson NC, Rubin AS. et al. Asthma control during the year after bronchial thermoplasty. N Engl J Med 2007; 356: 1327-1337
  • 446 Wechsler ME, Laviolette M, Rubin AS. et al. Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol 2013; 132: 1295-1302
  • 447 Cazzola M, Calzetta L, Bettoncelli G. et al. Asthma and comorbid medical illness. Eur Respir J 2011; 38: 42-49
  • 448 Gershon AS, Wang C, Guan J. et al. Burden of comorbidity in individuals with asthma. Thorax 2010; 65: 612-618
  • 449 Havemann BD, Henderson CA, El-Serag HB. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut 2007; 56: 1654-1664
  • 450 Maher MM, Darwish AA. Study of respiratory disorders in endoscopically negative and positive gastroesophageal reflux disease. Saudi J Gastroenterol 2010; 16: 84-89
  • 451 Prosser R, Carleton B, Smith A. The comorbidity burden of the treated asthma patient population in British Columbia. Chronic Dis Can 2010; 30: 46-55
  • 452 Tsai MC, Lin HL, Lin CC. et al. Increased risk of concurrent asthma among patients with gastroesophageal reflux disease: a nationwide population-based study. Eur J Gastroenterol Hepatol 2010; 22: 1169-1173
  • 453 Khorasani EN, Fallahi GH, Mansouri F. et al. The effect of omeprazole on asthmatic adolescents with gastroesophageal reflux disease. Allergy Asthma Proc 2008; 29: 517-520
  • 454 Sharma B, Sharma M, Daga MK. et al. Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux. World J Gastroenterol 2007; 13: 1706-1710
  • 455 Shimizu Y, Dobashi K, Zhao JJ. et al. Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease. Respiration 2007; 74: 558-564
  • 456 Chan WW, Chiou E, Obstein KL. et al. The efficacy of proton pump inhibitors for the treatment of asthma in adults: a meta-analysis. Arch Intern Med 2011; 171: 620-629
  • 457 Writing Committee for the American Lung Association Asthma Clinical Research Centers; Holbrook JT. Wise RA. Gold BD et al. Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA 2012; 307: 373-381
  • 458 Kiljander TO, Junghard O, Beckman O. et al. Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 2010; 181: 1042-1048
  • 459 American Lung Association Asthma Clinical Research Centers; Mastronarde JG. Anthonisen NR. Castro M et al. Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med 2009; 360: 1487-1499
  • 460 Riscili BP, Parsons JP, Mastronarde JG. Treating silent reflux disease does not improve poorly controlled asthma. Cleve Clin J Med 2010; 77: 155-160
  • 461 Julien JY, Martin JG, Ernst P. et al. Prevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma. J Allergy Clin Immunol 2009; 124: 371-376
  • 462 Teodorescu M, Consens FB, Bria WF. et al. Predictors of habitual snoring and obstructive sleep apnea risk in patients with asthma. Chest 2009; 135: 1125-1132
  • 463 Teodorescu M, Polomis DA, Hall SV. et al. Association of obstructive sleep apnea risk with asthma control in adults. Chest 2010; 138: 543-550
  • 464 Yigla M, Tov N, Solomonov A. et al. Difficult-to-control asthma and obstructive sleep apnea. J Asthma 2003; 40: 865-871
  • 465 Deutsche Gesellschaft für Schlafforschung und Schlafmedizin. S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen – Kapitel „Schlafbezogene Atmungsstörungen“. Somnologie 2017; 20: S97-S180
  • 466 Ehlayel MS, Bener A, Sabbah A. Is high prevalence of vitamin D deficiency evidence for asthma and allergy risks?. Eur Ann Allergy Clin Immunol 2011; 43: 81-88
  • 467 Li F, Peng M, Jiang L. et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration 2011; 81: 469-475
  • 468 Erkkola M, Kaila M, Nwaru BI. et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 2009; 39: 875-882
  • 469 Todd DC, Armstrong S, DʼSilva L. et al. Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clin Exp Allergy 2007; 37: 1049-1054
  • 470 Kim KM, Kim SS, Kwon JW. et al. Association between subcutaneous abdominal fat and airway hyperresponsiveness. Allergy Asthma Proc 2011; 32: 68-73
  • 471 Yoo S, Kim HB, Lee SY. et al. Association between obesity and the prevalence of allergic diseases, atopy, and bronchial hyperresponsiveness in Korean adolescents. Int Arch Allergy Immunol 2011; 154: 42-48
  • 472 Ciprandi G, Pistorio A, Tosca M. et al. Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma. Respir Med 2009; 103: 289-295
  • 473 Kilic H, Oguzulgen IK, Bakir F. et al. Asthma in obese women: outcomes and factors involved. J Investig Allergol Clin Immunol 2011; 21: 290-296
  • 474 Farah CS, Kermode JA, Downie SR. et al. Obesity is a determinant of asthma control independent of inflammation and lung mechanics. Chest 2011; 140: 659-666
  • 475 McGinley B, Punjabi NM. Obesity, metabolic abnormalities, and asthma: establishing causal links. Am J Respir Crit Care Med 2011; 183: 424-425
  • 476 Peters JI, McKinney JM, Smith B. et al. Impact of obesity in asthma: evidence from a large prospective disease management study. Ann Allergy Asthma Immunol 2011; 106: 30-35
  • 477 Raviv S, Dixon AE, Kalhan R. et al. Effect of obesity on asthma phenotype is dependent upon asthma severity. J Asthma 2011; 48: 98-104
  • 478 Thomsen SF, Duffy DL, Kyvik KO. et al. Risk of asthma in adult twins with type 2 diabetes and increased body mass index. Allergy 2011; 66: 562-568
  • 479 Minas M, Papaioannou AI, Tsaroucha A. et al. Body composition in severe refractory asthma: comparison with COPD patients and healthy smokers. PloS one 2010; 5: e13233
  • 480 Song Y, Klevak A, Manson JE. et al. Asthma, chronic obstructive pulmonary disease, and type 2 diabetes in the Womenʼs Health Study. Diabetes Res Clin Pract 2010; 90: 365-371
  • 481 Dixon AE, Holguin F, Sood A. et al. An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc 2010; 7: 325-335
  • 482 Sinniah D. Obesity: links to diabetes and asthma. Intern Med J 2010; 40: 471-472
  • 483 Grammer LC, Weiss KB, Pedicano JB. et al. Obesity and asthma morbidity in a community-based adult cohort in a large urban area: the Chicago Initiative to Raise Asthma Health Equity (CHIRAH). J Asthma 2010; 47: 491-495
  • 484 Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy 2010; 65: 1455-1463
  • 485 Camargo CA, Sutherland ER, Bailey W. et al. Effect of increased body mass index on asthma risk, impairment and response to asthma controller therapy in African Americans. Curr Med Res Opin 2010; 26: 1629-1635
  • 486 Wilson DH, Appleton SL, Taylor AW. et al. Depression and obesity in adults with asthma: multiple comorbidities and management issues. Med J Aust 2010; 192: 381-383
  • 487 Farah CS, Boulet LP, Reddel HK. Obesity and asthma control in an urban population. J Allergy Clin Immunol 2010; 125: 769-770
  • 488 Jordan JG, Mann JR. Obesity and mortality in persons with obstructive lung disease using data from the NHANES III. South Med J 2010; 103: 323-330
  • 489 Uddenfeldt M, Janson C, Lampa E. et al. High BMI is related to higher incidence of asthma, while a fish and fruit diet is related to a lower- Results from a long-term follow-up study of three age groups in Sweden. Respir Med 2010; 104: 972-980
  • 490 Pakhale S, Doucette S, Vandemheen K. et al. A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction. Chest 2010; 137: 1316-1323
  • 491 Hjellvik V, Tverdal A, Furu K. Body mass index as predictor for asthma: a cohort study of 118,723 males and females. Eur Respir J 2010; 35: 1235-1242
  • 492 McHugh MK, Symanski E, Pompeii LA. et al. Prevalence of asthma among adult females and males in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2001-2004. J Asthma 2009; 46: 759-766
  • 493 Ahmad N, Biswas S, Bae S. et al. Association between obesity and asthma in US children and adolescents. J Asthma 2009; 46: 642-646
  • 494 Clerisme-Beaty E, Rand CS. The effect of obesity on asthma incidence: moving past the epidemiologic evidence. J Allergy Clin Immunol 2009; 123: 96-97
  • 495 Coogan PF, Palmer JR, O'Connor GT. et al. Body mass index and asthma incidence in the Black Women's Health Study. J Allergy Clin Immunol 2009; 123: 89-95
  • 496 Mosen DM, Schatz M, Magid DJ. et al. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 2008; 122: 507-511
  • 497 Eneli IU, Skybo T, Camargo CA. Weight loss and asthma: a systematic review. Thorax 2008; 63: 671-676
  • 498 McClean KM, Kee F, Young IS. et al. Obesity and the lung: 1. Epidemiology. Thorax 2008; 63: 649-654
  • 499 Taylor B, Mannino D, Brown C. et al. Body mass index and asthma severity in the National Asthma Survey. Thorax 2008; 63: 14-20
  • 500 Thomsen SF, Ulrik CS, Kyvik KO. et al. Association between obesity and asthma in a twin cohort. Allergy 2007; 62: 1199-1204
  • 501 Sood A. Sex differences: implications for the obesity-asthma association. Exerc Sport Sci Rev 2011; 39: 48-56
  • 502 Forno E, Lescher R, Strunk R. et al. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011; 127: 741-749
  • 503 Barranco P, Delgado J, Sastre J. et al. Obesity is not associated with mild asthma diagnosis in a population of Spanish adults. J Asthma 2009; 46: 867-871
  • 504 Musaad SM, Patterson T, Ericksen M. et al. Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant. J Allergy Clin Immunol 2009; 123: 1321-1327
  • 505 Thuesen BH, Husemoen LL, Hersoug LG. et al. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy 2009; 39: 700-707
  • 506 Lombardi C, Gargioni S, Gardinazzi A. et al. Impact of bariatric surgery on pulmonary function and nitric oxide in asthmatic and non-asthmatic obese patients. J Asthma 2011; 48: 553-557
  • 507 Brancatisano A, Wahlroos S, Brancatisano R. Improvement in comorbid illness after placement of the Swedish Adjustable Gastric Band. Surg Obes Relat Dis 2008; 4: S39-S46
  • 508 Peluso L, Vanek VW. Efficacy of gastric bypass in the treatment of obesity-related comorbidities. Nutr Clin Pract 2007; 22: 22-28
  • 509 Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it?. Thorax 2009; 64: 728-735
  • 510 Hardin M, Silverman EK, Barr RG. et al. The clinical features of the overlap between COPD and asthma. Respir Res 2011; 12: 127
  • 511 Andersén H, Lampela P, Nevanlinna A. et al. High hospital burden in overlap syndrome of asthma and COPD. Clin Respir J 2013; 7: 342-346
  • 512 Blanchette CM, Broder M, Ory C. et al. Cost and utilization of COPD and asthma among insured adults in the US. Curr Med Res Opin 2009; 25: 1385-1392
  • 513 de Marco R, Pesce G, Marcon A. et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PloS one 2013; 8: e62985
  • 514 Hardin M, Cho M, McDonald ML. et al. The clinical and genetic features of COPD-asthma overlap syndrome. Eur Respir J 2014; 44: 341-350
  • 515 Iwamoto H, Gao J, Koskela J. et al. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap. Eur Respir J 2014; 43: 421-429
  • 516 Izquierdo-Alonso JL, Rodriguez-Gonzálezmoro JM, de Lucas-Ramos P. et al. Prevalence and characteristics of three clinical phenotypes of chronic obstructive pulmonary disease (COPD). Respir Med 2013; 107: 724-731
  • 517 Kauppi P, Kupiainen H, Lindqvist A. et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma 2011; 48: 279-285
  • 518 Kitaguchi Y, Komatsu Y, Fujimoto K. et al. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int J Chron Obstruct Pulmon Dis 2012; 7: 283-289
  • 519 Marsh SE, Travers J, Weatherall M. et al. Proportional classifications of COPD phenotypes. Thorax 2008; 63: 761-767
  • 520 Menezes AM, Montes de Oca M, Pérez-Padilla R. et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest 2014; 145: 297-304
  • 521 Miravitlles M, Soler-Cataluña JJ, Calle M. et al. Treatment of COPD by clinical phenotypes: putting old evidence into clinical practice. Eur Respir J 2013; 41: 1252-1256
  • 522 Pleasants RA, Ohar JA, Croft JB. et al. Chronic obstructive pulmonary disease and asthma-patient characteristics and health impairment. COPD 2014; 11: 256-266
  • 523 Putcha N, Drummond MB, Wise RA. et al. Comorbidities and Chronic Obstructive Pulmonary Disease: Prevalence, Influence on Outcomes, and Management. Semin Respir Crit Care Med 2015; 36: 575-591
  • 524 Rhee CK, Yoon HK, Yoo KH. et al. Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma. COPD 2014; 11: 163-170
  • 525 Shaya FT, Dongyi D, Akazawa MO. et al. Burden of concomitant asthma and COPD in a Medicaid population. Chest 2008; 134: 14-19
  • 526 Tálamo C, de Oca MM, Halbert R. et al. Diagnostic labeling of COPD in five Latin American cities. Chest 2007; 131: 60-67
  • 527 Wurst KE, Shukla A, Muellerova H. et al. Respiratory pharmacotherapy use in patients newly diagnosed with chronic obstructive pulmonary disease in a primary care setting in the UK: a retrospective cohort study. COPD 2014; 11: 521-530
  • 528 Diaz-Guzman E, Khosravi M, Mannino DM. Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population. COPD 2011; 8: 400-407
  • 529 Brightling CE, McKenna S, Hargadon B. et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax 2005; 60: 193-198
  • 530 Leigh R, Pizzichini MM, Morris MM. et al. Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J 2006; 27: 964-971
  • 531 O'Donnell DE, Aaron S, Bourbeau J. et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J 2007; 14: 5B-32B
  • 532 Barrecheguren M, Esquinas C, Miravitlles M. The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges. Curr Opin Pulm Med 2015; 21: 74-79
  • 533 Brusselle GG, Bracke K, Lahousse L. Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts. Lancet Respir Med 2015; 3: 416-417
  • 534 Iqbal A, Barnes NC, Brooks J. Is Blood Eosinophil Count a Predictor of Response to Bronchodilators in Chronic Obstructive Pulmonary Disease? Results from Post Hoc Subgroup Analyses. Clin Drug Investig 2015; 35: 685-688
  • 535 Park HY, Lee H, Koh WJ. et al. Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients. Int J Chron Obstruct Pulmon Dis 2016; 11: 23-30
  • 536 Pascoe S, Locantore N, Dransfield MT. et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med 2015; 3: 435-442
  • 537 Pavord ID, Lettis S, Locantore N. et al. Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD. Thorax 2016; 71: 118-125
  • 538 Siddiqui SH, Guasconi A, Vestbo J. et al. Blood Eosinophils: A Biomarker of Response to Extrafine Beclomethasone/Formoterol in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2015; 192: 523-525
  • 539 Marple BF. Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace. Am J Rhinol Allergy 2010; 24: 249-254
  • 540 Guerra S, Sherrill DL, Martinez FD. et al. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002; 109: 419-425
  • 541 Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001; 108: S147-334
  • 542 Stevenson DD, Mathison DA, Tan EM. et al. Provoking factors in bronchial asthma. Arch Intern Med 1975; 135: 777-783
  • 543 Settipane RJ, Hagy GW, Settipane GA. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc 1994; 15: 21-25
  • 544 Huovinen E, Kaprio J, Laitinen LA. et al. Incidence and prevalence of asthma among adult Finnish men and women of the Finnish Twin Cohort from 1975 to 1990, and their relation to hay fever and chronic bronchitis. Chest 1999; 115: 928-936
  • 545 Braman SS, Barrows AA, DeCotiis BA. et al. Airway hyperresponsiveness in allergic rhinitis. A risk factor for asthma. Chest 1987; 91: 671-674
  • 546 Ciprandi G, Cirillo I, Tosca MA. et al. Bronchial hyperreactivity and spirometric impairment in patients with perennial allergic rhinitis. Int Arch Allergy Immunol 2004; 133: 14-18
  • 547 Ciprandi G, Cirillo I, Tosca MA. et al. Bronchial hyperreactivity and spirometric impairment in patients with seasonal allergic rhinitis. Respir Med 2004; 98: 826-831
  • 548 Ciprandi G, Cirillo I, Pistorio A. et al. Impact of allergic rhinitis on asthma: effects on bronchodilation testing. Ann Allergy Asthma Immunol 2008; 101: 42-46
  • 549 Ciprandi G, Capasso M, Tosca MA. Early bronchial involvement in children with allergic rhinitis. Am J Rhinol Allergy 2011; 25: e30-e33
  • 550 Ciprandi G, Signori A, Cirillo I. Relationship between bronchial hyperreactivity and bronchodilation in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2011; 106: 460-466
  • 551 Braunstahl GJ, Overbeek SE, Kleinjan A. et al. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol 2001; 107: 469-476
  • 552 Braunstahl GJ, Kleinjan A, Overbeek SE. et al. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med 2000; 161: 2051-2057
  • 553 Gaga M, Lambrou P, Papageorgiou N. et al. Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis. Clin Exp Allergy 2000; 30: 663-669
  • 554 Becky Kelly EA, Busse WW, Jarjour NN. A comparison of the airway response to segmental antigen bronchoprovocation in atopic asthma and allergic rhinitis. J Allergy Clin Immunol 2003; 111: 79-86
  • 555 Kurt E, Aktas A, Gulbas Z. et al. The effects of natural pollen exposure on inflammatory cytokines and their relationship with nonspecific bronchial hyperresponsiveness in seasonal allergic rhinitis. Allergy Asthma Proc 2010; 31: 126-131
  • 556 Pinart M, Benet M, Annesi-Maesano I. et al. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. Lancet Respir Med 2014; 2: 131-140
  • 557 Brozek JL, Bousquet J, Baena-Cagnani CE. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010; 126: 466-476
  • 558 Welsh PW, Stricker WE, Chu CP. et al. Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. Mayo Clin Proc 1987; 62: 125-134
  • 559 Henriksen JM, Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am Rev Respir Dis 1984; 130: 1014-1018
  • 560 Corren J, Adinoff AD, Buchmeier AD. et al. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 1992; 90: 250-256
  • 561 Aubier M, Levy J, Clerici C. et al. Different effects of nasal and bronchial glucocorticosteroid administration on bronchial hyperresponsiveness in patients with allergic rhinitis. Am Rev Respir Dis 1992; 146: 122-126
  • 562 Dahl R, Nielsen LP, Kips J. et al. Intranasal and inhaled fluticasone propionate for pollen-induced rhinitis and asthma. Allergy 2005; 60: 875-881
  • 563 Yatera K, Yamasaki K, Noguchi S. et al. Prevalence of sinusitis and efficacy of intranasal corticosteroid treatment on asthmatic symptoms in asthmatic patients with rhinosinusitis: a pilot study. Int Forum Allergy Rhinol 2016; 6: 398-406
  • 564 Grant JA, Nicodemus CF, Findlay SR. et al. Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. J Allergy Clin Immunol 1995; 95: 923-932
  • 565 Spector SL, Nicodemus CF, Corren J. et al. Comparison of the bronchodilatory effects of cetirizine, albuterol, and both together versus placebo in patients with mild-to-moderate asthma. J Allergy Clin Immunol 1995; 96: 174-181
  • 566 Aubier M, Neukirch C, Peiffer C. et al. Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma. Allergy 2001; 56: 35-42
  • 567 Crystal-Peters J, Neslusan C, Crown WH. et al. Treating allergic rhinitis in patients with comorbid asthma: the risk of asthma-related hospitalizations and emergency department visits. J Allergy Clin Immunol 2002; 109: 57-62
  • 568 Corren J, Manning BE, Thompson SF. et al. Rhinitis therapy and the prevention of hospital care for asthma: a case-control study. J Allergy Clin Immunol 2004; 113: 415-419
  • 569 Chun TH, Weitzen SH, Fritz GK. The asthma/mental health nexus in a population-based sample of the United States. Chest 2008; 134: 1176-1182
  • 570 Katon W, Lozano P, Russo J. et al. The prevalence of DSM-IV anxiety and depressive disorders in youth with asthma compared with controls. J Adolesc Health 2007; 41: 455-463
  • 571 Scott KM, Von Korff M, Ormel J. et al. Mental disorders among adults with asthma: results from the World Mental Health Survey. Gen Hosp Psychiatry 2007; 29: 123-133
  • 572 Katon WJ, Richardson L, Russo J. et al. Quality of mental health care for youth with asthma and comorbid anxiety and depression. Med Care 2006; 44: 1064-1072
  • 573 Di Marco F, Verga M, Santus P. et al. Close correlation between anxiety, depression, and asthma control. Respir Med 2010; 104: 22-28
  • 574 Goodwin RD, Pagura J, Cox B. et al. Asthma and mental disorders in Canada: impact on functional impairment and mental health service use. J Psychosom Res 2010; 68: 165-173
  • 575 Kozyrskyj AL, Mai XM, McGrath P. et al. Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma. Am J Respir Crit Care Med 2008; 177: 142-147
  • 576 Richardson LP, Russo JE, Lozano P. et al. The effect of comorbid anxiety and depressive disorders on health care utilization and costs among adolescents with asthma. Gen Hosp Psychiatry 2008; 30: 398-406
  • 577 Strine TW, Mokdad AH, Balluz LS. et al. Impact of depression and anxiety on quality of life, health behaviors, and asthma control among adults in the United States with asthma, 2006. J Asthma 2008; 45: 123-133
  • 578 von Leupoldt A, Dahme B. Psychological aspects in the perception of dyspnea in obstructive pulmonary diseases. Respir Med 2007; 101: 411-422
  • 579 von Leupoldt A, Sommer T, Kegat S. et al. Down-regulation of insular cortex responses to dyspnea and pain in asthma. Am J Respir Crit Care Med 2009; 180: 232-238
  • 580 von Leupoldt A, Chan PY, Bradley MM. et al. The impact of anxiety on the neural processing of respiratory sensations. NeuroImage 2011; 55: 247-252
  • 581 Lecheler J. Gesellschaftlicher Kontext: Schule. In: Lingner H, Schwartz FW, Schultz K. Hrsg. Volkskrankheit Asthma/COPD. Heidelberg : Springer Medizin Verlag; 2007
  • 582 Cookson H, Granell R, Joinson C. et al. Mothers' anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol 2009; 123: 847-853
  • 583 Boulet LP. Influence of comorbid conditions on asthma. Eur Respir J 2009; 33: 897-906
  • 584 Ahnert J, Löffler S, Müller J. et al. [Systematic literature review on interventions in rehabilitation for children and adolescents with asthma bronchiale]. Rehabilitation 2010; 49: 147-159
  • 585 Menz G, Kronenberger H, Lecheler J. et al. [Pulmonary rehabilitation in asthma bronchiale]. Pneumologie 2007; 61: 710-718
  • 586 Petermann F, Warschburger P. Asthma bronchiale. Göttingen: Hogrefe; 2000
  • 587 Zacharasiewicz A. Maternal smoking in pregnancy and its influence on childhood asthma. ERJ Open Res 2016; 2: 00042-2016
  • 588 Schäfer T, Bauer CP, Beyer K. et al. S3-Guideline on allergy prevention: 2014 update: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Society for Pediatric and Adolescent Medicine (DGKJ). Allergo J Int 2014; 23: 186-199
  • 589 Schäfer T, Borowski C, Diepgen TL. et al. [Evidence-based and consented guideline on allergy prevention]. J Dtsch Dermatol Ges 2004; 2: 1030-1036
  • 590 Wahn U, von Mutius E. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol 2001; 107: 567-574
  • 591 Becker AB. Is primary prevention of asthma possible?. Pediatr Pulmonol 2000; 30: 63-72
  • 592 Haahtela T, Holgate S, Pawankar R. et al. The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J 2013; 6: 3
  • 593 Karvonen AM, Hyvärinen A, Gehring U. et al. Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas. Clin Exp Allergy 2012; 42: 1246-1256
  • 594 Peters M, Kauth M, Schwarze J. et al. Inhalation of stable dust extract prevents allergen induced airway inflammation and hyperresponsiveness. Thorax 2006; 61: 134-139
  • 595 Braun-Fahrländer C, Riedler J, Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347: 869-877
  • 596 Riedler J, Braun-Fahrländer C, Eder W. et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358: 1129-1133
  • 597 Ege MJ, Frei R, Bieli C. et al. Not all farming environments protect against the development of asthma and wheeze in children. J Allergy Clin Immunol 2007; 119: 1140-1147
  • 598 Chan-Yeung M, Becker A. Primary prevention of childhood asthma and allergic disorders. Curr Opin Allergy Clin Immunol 2006; 6: 146-151
  • 599 Oddy WH, Holt PG, Sly PD. et al. Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study. BMJ 1999; 319: 815-819
  • 600 Maas T, Kaper J, Sheikh A. et al. Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev 2009; 3: CD006480
  • 601 Hide DW, Matthews S, Tariq S. et al. Allergen avoidance in infancy and allergy at 4 years of age. Allergy 1996; 51: 89-93
  • 602 Boyle RJ, Ierodiakonou D, Khan T. et al. Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis. BMJ 2016; 352: i974
  • 603 von Berg A, Filipiak-Pittroff B, Schulz H. et al. Allergic manifestation 15 years after early intervention with hydrolyzed formulas--the GINI Study. Allergy 2016; 71: 210-219
  • 604 von Berg A, Filipiak-Pittroff B, Krämer U. et al. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 2008; 121: 1442-1447
  • 605 von Berg A, Krämer U, Link E. et al. Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course - the GINIplus study up to the age of 6 years. Clin Exp Allergy 2010; 40: 627-636
  • 606 Schoetzau A, Gehring U, Wichmann HE. Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review. Eur J Pediatr 2001; 160: 323-332
  • 607 Vandenplas Y, Hauser B, Van den Borre C. et al. The long-term effect of a partial whey hydrolysate formula on the prophylaxis of atopic disease. Eur J Pediatr 1995; 154: 488-494
  • 608 Azad MB, Coneys JG, Kozyrskyj AL. et al. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ 2013; 347: f6471
  • 609 Grüber C, van Stuijvenberg M, Mosca F. et al. Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol 2010; 126: 791-797
  • 610 Kuitunen M, Kukkonen K, Juntunen-Backman K. et al. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. J Allergy Clin Immunol 2009; 123: 335-341
  • 611 Kopp MV, Hennemuth I, Heinzmann A. et al. Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics 2008; 121: e850-856
  • 612 Kukkonen K, Savilahti E, Haahtela T. et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007; 119: 192-198
  • 613 Moro G, Arslanoglu S, Stahl B. et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006; 91: 814-819
  • 614 Dunstan JA, Mori TA, Barden A. et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003; 112: 1178-1184
  • 615 Rautava S, Kalliomäki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol 2002; 109: 119-121
  • 616 Kalliomäki M, Salminen S, Arvilommi H. et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001; 357: 1076-1079
  • 617 Zutavern A, Brockow I, Schaaf B. et al. Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics 2008; 121: e44-52
  • 618 Filipiak B, Zutavern A, Koletzko S. et al. Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study. J Pediatr 2007; 151: 352-358
  • 619 Flexeder C, Thiering E, Brüske I. et al. Growth velocity during infancy and onset of asthma in school-aged children. Allergy 2012; 67: 257-264
  • 620 Zammit C, Liddicoat H, Moonsie I. et al. Obesity and respiratory diseases. Int J Gen Med 2010; 3: 335-343
  • 621 Delgado J, Barranco P, Quirce S. Obesity and asthma. J Investig Allergol Clin Immunol 2008; 18: 420-425
  • 622 Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007; 175: 661-666
  • 623 Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005; 115: 897-909
  • 624 Wongtrakool C, Wang N, Hyde DM. et al. Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. Am J Respir Cell Mol Biol 2012; 46: 695-702
  • 625 Burke H, Leonardi-Bee J, Hashim A. et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics 2012; 129: 735-744
  • 626 Horak F, Fazekas T, Zacharasiewicz A. et al. [The Fetal Tobacco Syndrome - A statement of the Austrian Societies for General- and Family Medicine (ÖGAM), Gynecology and Obstetrics (ÖGGG), Hygiene, Microbiology and Preventive Medicine (ÖGHMP), Pediatrics and Adolescence Medicine (ÖGKJ) as well as Pneumology (ÖGP)]. Wien Klin Wochenschr 2012; 124: 129-145
  • 627 Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001; 163: 429-436
  • 628 Tariq SM, Hakim EA, Matthews SM. et al. Influence of smoking on asthmatic symptoms and allergen sensitisation in early childhood. Postgrad Med J 2000; 76: 694-699
  • 629 Strachan DP, Cook DG. Health effects of passive smoking. 6. Parental smoking and childhood asthma: longitudinal and case-control studies. Thorax 1998; 53: 204-212
  • 630 Tarlo SM, Liss GM, Yeung KS. Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures. Occup Environ Med 2002; 59: 58-62
  • 631 Merget R, Caspari C, Dierkes-Globisch A. et al. Effectiveness of a medical surveillance program for the prevention of occupational asthma caused by platinum salts: a nested case-control study. J Allergy Clin Immunol 2001; 107: 707-712
  • 632 Schönberger HJ, Maas T, Dompeling E. et al. Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens-a randomized trial. Clin Exp Allergy 2004; 34: 1024-1031
  • 633 Lodge CJ, Lowe AJ, Gurrin LC. et al. House dust mite sensitization in toddlers predicts current wheeze at age 12 years. J Allergy Clin Immunol 2011; 128: 782-788
  • 634 Celedón JC, Milton DK, Ramsey CD. et al. Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood. J Allergy Clin Immunol 2007; 120: 144-149
  • 635 Schram-Bijkerk D, Doekes G, Boeve M. et al. Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children. Allergy 2006; 61: 640-647
  • 636 Gøtzsche PC, Johansen HK, Schmidt LM. et al. House dust mite control measures for asthma. Cochrane Database Syst Rev 2004; 4: CD001187
  • 637 Lau S, Illi S, Sommerfeld C. et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet 2000; 356: 1392-1397
  • 638 Gøtzsche PC, Hammarquist C, Burr M. House dust mite control measures in the management of asthma: meta-analysis. BMJ 1998; 317: 1105-1110
  • 639 Kuehr J, Frischer T, Meinert R. et al. Mite allergen exposure is a risk for the incidence of specific sensitization. J Allergy Clin Immunol 1994; 94: 44-52
  • 640 Sporik R, Holgate ST, Platts-Mills TA. et al. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med 1990; 323: 502-507
  • 641 Lau S, Falkenhorst G, Weber A. et al. High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. J Allergy Clin Immunol 1989; 84: 718-725
  • 642 Perzanowski MS, Chew GL, Divjan A. et al. Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort. J Allergy Clin Immunol 2008; 121: 1047-1052
  • 643 Takkouche B, González-Barcala FJ, Etminan M. et al. Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis. Allergy 2008; 63: 857-864
  • 644 Bufford JD, Gern JE. Early exposure to pets: good or bad?. Curr Allergy Asthma Rep 2007; 7: 375-382
  • 645 Waser M, von Mutius E, Riedler J. et al. Exposure to pets, and the association with hay fever, asthma, and atopic sensitization in rural children. Allergy 2005; 60: 177-184
  • 646 Brussee JE, Smit HA, van Strien RT. et al. Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. J Allergy Clin Immunol 2005; 115: 946-952
  • 647 Svanes C, Heinrich J, Jarvis D. et al. Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol 2003; 112: 289-300
  • 648 Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002; 288: 963-972
  • 649 Custovic A, Simpson BM, Simpson A. et al. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet 2001; 358: 188-193
  • 650 Melén E, Wickman M, Nordvall SL. et al. Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children. Allergy 2001; 56: 646-652
  • 651 Remes ST, Castro-Rodriguez JA, Holberg CJ. et al. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001; 108: 509-515
  • 652 Hesselmar B, Aberg N, Aberg B. et al. Does early exposure to cat or dog protect against later allergy development?. Clin Exp Allergy 1999; 29: 611-617
  • 653 Perzanowski MS, Rönmark E, Platts-Mills TA. et al. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002; 166: 696-702
  • 654 Campo P, Kalra HK, Levin L. et al. Influence of dog ownership and high endotoxin on wheezing and atopy during infancy. J Allergy Clin Immunol 2006; 118: 1271-1278
  • 655 Litonjua AA, Milton DK, Celedon JC. et al. A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol 2002; 110: 736-742
  • 656 Chen CM, Morgenstern V, Bischof W. et al. Dog ownership and contact during childhood and later allergy development. Eur Respir J 2008; 31: 963-973
  • 657 Tischer CG, Hohmann C, Thiering E. et al. Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative. Allergy 2011; 66: 1570-1579
  • 658 Tischer C, Chen CM, Heinrich J. Association between domestic mould and mould components, and asthma and allergy in children: a systematic review. Eur Respir J 2011; 38: 812-824
  • 659 Tischer C, Gehring U, Chen CM. et al. Respiratory health in children, and indoor exposure to (1,3)-β-D-glucan, EPS mould components and endotoxin. Eur Respir J 2011; 37: 1050-1059
  • 660 Fisk WJ, Lei-Gomez Q, Mendell MJ. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor air 2007; 17: 284-296
  • 661 Wiesmüller GA, Heinzow B, Aurbach U. et al. [Medical Diagnostics for Mold Exposure Indoors]. Pneumologie 2016; 70: 699-741
  • 662 Gasana J, Dillikar D, Mendy A. et al. Motor vehicle air pollution and asthma in children: a meta-analysis. Environ Res 2012; 117: 36-45
  • 663 Sonnenschein-van der Voort AM, de Kluizenaar Y, Jaddoe VW. et al. Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort. Environ Health 2012; 11: 91
  • 664 Morgenstern V, Zutavern A, Cyrys J. et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med 2008; 177: 1331-1337
  • 665 Morgenstern V, Zutavern A, Cyrys J. et al. Respiratory health and individual estimated exposure to traffic-related air pollutants in a cohort of young children. Occup Environ Med 2007; 64: 8-16
  • 666 Nicolai T, Carr D, Weiland SK. et al. Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J 2003; 21: 956-963
  • 667 Scott M, Roberts G, Kurukulaaratchy RJ. et al. Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax 2012; 67: 1046-1051
  • 668 van Schayck OC, Maas T, Kaper J. et al. Is there any role for allergen avoidance in the primary prevention of childhood asthma?. J Allergy Clin Immunol 2007; 119: 1323-1328
  • 669 Chan-Yeung M, Ferguson A, Watson W. et al. The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol 2005; 116: 49-55
  • 670 Schönberger HJ, Dompeling E, Knottnerus JA. et al. The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma. Eur Respir J 2005; 25: 660-670
  • 671 Becker A, Watson W, Ferguson A. et al. The Canadian asthma primary prevention study: outcomes at 2 years of age. J Allergy Clin Immunol 2004; 113: 650-656
  • 672 Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax 2003; 58: 489-493
  • 673 Marra F, Marra CA, Richardson K. et al. Antibiotic use in children is associated with increased risk of asthma. Pediatrics 2009; 123: 1003-1010
  • 674 Stensballe LG, Simonsen J, Jensen SM. et al. Use of antibiotics during pregnancy increases the risk of asthma in early childhood. J Pediatr 2013; 162: 832-838
  • 675 Celedón JC, Fuhlbrigge A, Rifas-Shiman S. et al. Antibiotic use in the first year of life and asthma in early childhood. Clin Exp Allergy 2004; 34: 1011-1016
  • 676 Etminan M, Sadatsafavi M, Jafari S. et al. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. Chest 2009; 136: 1316-1323
  • 677 Eyers S, Weatherall M, Jefferies S. et al. Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis. Clin Exp Allergy 2011; 41: 482-489
  • 678 Thavagnanam S, Fleming J, Bromley A. et al. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy 2008; 38: 629-633
  • 679 Azad MB, Konya T, Maughan H. et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 2013; 185: 385-394
  • 680 Alm JS, Lilja G, Pershagen G. et al. BCG vaccination does not seem to prevent atopy in children with atopic heredity. Allergy 1998; 53: 537
  • 681 Alm JS, Lilja G, Pershagen G. et al. Early BCG vaccination and development of atopy. Lancet 1997; 350: 400-403
  • 682 Blanc PD, Toren K. How much adult asthma can be attributed to occupational factors?. Am J Med 1999; 107: 580-587
  • 683 Balmes J, Becklake M, Blanc P. et al. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med 2003; 167: 787-797
  • 684 Mapp CE, Boschetto P, Maestrelli P. et al. Occupational asthma. Am J Respir Crit Care Med 2005; 172: 280-305
  • 685 Kogevinas M, Zock JP, Jarvis D. et al. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet 2007; 370: 336-341
  • 686 Baur X, Bakehe P, Vellguth H. Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach. J Occup Med Toxicol 2012; 7: 19
  • 687 Burge PS, Moore VC, Robertson AS. Sensitization and irritant-induced occupational asthma with latency are clinically indistinguishable. Occup Med 2012; 62: 129-133
  • 688 Brooks SM, Weiss MA, Bernstein IL. Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures. Chest 1985; 88: 376-384
  • 689 Nowak D. Chemosensory irritation and the lung. Int Arch Occup Environ Health 2002; 75: 326-331
  • 690 Le Moual N, Siroux V, Pin I. et al. Asthma severity and exposure to occupational asthmogens. Am J Respir Crit Care Med 2005; 172: 440-445
  • 691 Baur X. A compendium of causative agents of occupational asthma. J Occup Med Toxicol 2013; 8: 15
  • 692 Wilken D, Baur X, Barbinova L. et al. What are the benefits of medical screening and surveillance?. Eur Respir Rev 2012; 21: 105-111
  • 693 Vandenplas O, Ghezzo H, Munoz X. et al. What are the questionnaire items most useful in identifying subjects with occupational asthma?. Eur Respir J 2005; 26: 1056-1063
  • 694 Baur X, Drexler H, Kraus T. et al. Arbeitsmedizinische Leitlinie der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. (DGAUM). Arbeitsplatzbezogener Inhalationstest (AIT). Arbeitsmed Sozialmed Umweltmed 2010; 45: 434-441
  • 695 http://www.dguv.de/formtexte/aerzte/index.jsp
  • 696 Bundesregierung. Berufskrankheiten-Verordnung vom 31. Oktober 1997 (BGBl. I S. 2623), die zuletzt durch Artikel 1 der Verordnung vom 11. Juni 2009 (BGBl. I S. 1273) geändert worden ist. BGBl I; 2009
  • 697 Vandenplas O, Dressel H, Nowak D. et al. What is the optimal management option for occupational asthma?. Eur Respir Rev 2012; 21: 97-104
  • 698 Heederik D, Henneberger PK, Redlich CA. Primary prevention: exposure reduction, skin exposure and respiratory protection. Eur Respir Rev 2012; 21: 112-124
  • 699 Baur X, Sigsgaard T, Aasen TB. et al. Guidelines for the management of work-related asthma. Eur Respir J 2012; 39: 529-545
  • 700 Nicholson PJ, Cullinan P, Taylor AJ. et al. Evidence based guidelines for the prevention, identification, and management of occupational asthma. Occup Environ Med 2005; 62: 290-299
  • 701 Schatz M, Harden K, Forsythe A. et al. The course of asthma during pregnancy, post partum, and with successive pregnancies: a prospective analysis. J Allergy Clin Immunol 1988; 81: 509-517
  • 702 Gluck JC, Gluck PA. The effect of pregnancy on the course of asthma. Immunol Allergy Clin North Am 2006; 26: 63-80
  • 703 Murphy VE, Gibson PG, Smith R. et al. Asthma during pregnancy: mechanisms and treatment implications. Eur Respir J 2005; 25: 731-750
  • 704 Murphy VE, Clifton VL, Gibson PG. Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes. Thorax 2006; 61: 169-176
  • 705 Cydulka RK, Emerman CL, Schreiber D. et al. Acute asthma among pregnant women presenting to the emergency department. Am J Respir Crit Care Med 1999; 160: 887-892
  • 706 Murphy VE, Powell H, Wark PA. et al. A prospective study of respiratory viral infection in pregnant women with and without asthma. Chest 2013; 144: 420-427
  • 707 Mendola P, Laughon SK, Männistö TI. et al. Obstetric complications among US women with asthma. Am J Obstet Gynecol 2013; 208: 127-128 .e1
  • 708 Demissie K, Breckenridge MB, Rhoads GG. Infant and maternal outcomes in the pregnancies of asthmatic women. Am J Respir Crit Care Med 1998; 158: 1091-1095
  • 709 Murphy VE, Gibson PG. Asthma in pregnancy. Clin Chest Med 2011; 32: 93-110
  • 710 Salihu HM, Wilson RE. Epidemiology of prenatal smoking and perinatal outcomes. Early Hum Dev 2007; 83: 713-720
  • 711 Hodyl NA, Stark MJ, Scheil W. et al. Perinatal outcomes following maternal asthma and cigarette smoking during pregnancy. Eur Respir J 2014; 43: 704-716
  • 712 Lumley J, Oliver SS, Chamberlain C. et al. Interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev 2004; 4: CD001055
  • 713 Juniper EF, Bousquet J, Abetz L. et al. Identifying ‘well-controlled’ and ‘not well-controlled’ asthma using the Asthma Control Questionnaire. Respir Med 2006; 100: 616-621
  • 714 Lim AS, Stewart K, Abramson MJ. et al. Multidisciplinary Approach to Management of Maternal Asthma (MAMMA): a randomized controlled trial. Chest 2014; 145: 1046-1054
  • 715 National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol 2005; 115: 34-46
  • 716 Lim A, Stewart K, König K. et al. Systematic review of the safety of regular preventive asthma medications during pregnancy. Ann Pharmacother 2011; 45: 931-945
  • 717 Vogt H, Lindström K, Bråbäck L. et al. Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study. Pediatrics 2011; 127: 1052-1059
  • 718 Wendel PJ, Ramin SM, Barnett-Hamm C. et al. Asthma treatment in pregnancy: a randomized controlled study. Am J Obstet Gynecol 1996; 175: 150-154
  • 719 Schatz M, Leibman C. Inhaled corticosteroid use and outcomes in pregnancy. Ann Allergy Asthma Immunol 2005; 95: 234-238
  • 720 Beschluss des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM- RL) in Anlage IV: Therapiehinweis zu Omalizumab. Dtsch Arztebl 2011; 108: A600/ B-488/C-488
  • 721 Mylonas I. Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration. Arch Gynecol Obstet 2011; 283: 7-18
  • 722 Nelson-Piercy C. Asthma in pregnancy. Thorax 2001; 56: 325-328