Neurology International Open 2017; 01(04): E312-E315
DOI: 10.1055/s-0043-119865
New Developments in Neurology
© Georg Thieme Verlag KG Stuttgart · New York

New Results on Brain Stimulation in Chronic Pain

Andrea Antal
1   Department of Clinical Neurophysiology
,
Walter Paulus
1   Department of Clinical Neurophysiology
,
Veit Rohde
2   Department of Neurosurgery, University Medical Center, Georg-August University, Göttingen, Germany
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
09. November 2017 (online)

Abstract

Pain that has become chronic has lost its warning function and is associated with dysfunction of the so-called pain network. Systematic brain stimulation aims to normalize this network by modulating neuronal activities. Non-invasive DC stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) are considered effective in pain treatment. Here, the stimulation of the primary motor cortex (M1) plays a central role. If the pain is not adequately controlled by tDCS and rTMS, invasive procedures such as motor cortex stimulation (MCS) or deep brain stimulation are available as a last resort.

 
  • References

  • 1 Lang N, Siebner HR, Ward NS. et al. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?. Eur J Neurosci 2005; 22: 495-504
  • 2 van Schouwenburg MR, O'Shea J, Mars RB. et al. Controlling human striatal cognitive function via the frontal cortex. J Neurosci 2012; 32: 5631-5637
  • 3 Wang JX, Rogers LM, Gross EZ. et al. Targeted enhancement of cortical-hippocampal brain networks and associative memory. Science 2014; 345: 1054-1057
  • 4 Nitsche MA, Fricke K, Henschke U. et al. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J Physiol 2003; 553: 293-301
  • 5 Nitsche MA, Jaussi W, Liebetanz D. et al. Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology 2004; 29: 1573-1578
  • 6 Brunoni AR, Ferrucci R, Bortolomasi M. et al. Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the major depressive episode: findings from a naturalistic study. Eur Psychiatry 2013; 28: 356-361
  • 7 Brunoni AR, Junior RF, Kemp AH. et al. Differential improvement in depressive symptoms for tDCS alone and combined with pharmacotherapy: an exploratory analysis from the sertraline vs. electrical current therapy for treating depression clinical study. Int J Neuropsychopharmacol 2014; 17: 53-61
  • 8 Apkarian AV, Sosa Y, Sonty S. et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004; 24: 10410-10415
  • 9 Tsubokawa T, Katayama Y, Yamamoto T. et al. Chronic motor cortex stimulation for the treatment of central pain. Acta Neurochir Suppl (Wien) 1991; 52: 137-139
  • 10 Tsubokawa T, Katayama Y, Yamamoto T. et al Treatment of thalamic pain by chronic motor cortex stimulation. Pacing and Clinical Electrophysiology 1991; 14: 131-134
  • 11 Meyerson BA, Lindblom U, Linderoth B. et al. Motor cortex stimulation as treatment of trigeminal neuropathic pain. Acta Neurochir Suppl (Wien) 1993; 58: 150-153
  • 12 Lefaucheur JP, Drouot X, Nguyen JP. Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin 2001; 31: 247-252
  • 13 Lefaucheur JP. Transcranial magnetic stimulation in the management of pain. Suppl Clin Neurophysiol 2004; 57: 737-748
  • 14 Lefaucheur JP. Cortical neurostimulation for neuropathic pain: state of the art and perspectives. Pain 2016; 157 (Suppl. 01) S81-S89
  • 15 Lefaucheur JP, Andre-Obadia N, Antal A. et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol 2014; 125: 2150-2206
  • 16 Cruccu G, Garcia-Larrea L, Hansson P. et al. EAN guidelines on central neurostimulation therapy in chronic pain conditions. Eur J Neurol 2016; 23: 1489-1499
  • 17 Lefaucheur JP. Use of repetitive transcranial magnetic stimulation in pain relief. Expert Rev Neurother 2008; 8: 799-808
  • 18 O'Connell NE, Wand BM, Marston L. et al. Non-invasive brain stimulation techniques for chronic pain. A report of a Cochrane systematic review and meta-analysis. Eur J Phys Rehabil Med 2011; 47: 309-326
  • 19 Lefaucheur JP. Methods of therapeutic cortical stimulation. Neurophysiol Clin 2009; 39: 1-14
  • 20 Lefaucheur JP. New insights into the therapeutic potential of non-invasive transcranial cortical stimulation in chronic neuropathic pain. Pain 2006; 122: 11-13
  • 21 Andre-Obadia N, Mertens P, Lelekov-Boissard T. et al. Is Life better after motor cortex stimulation for pain control? Results at long-term and their prediction by preoperative rTMS. Pain Physician 2014; 17: 53-62
  • 22 Hosomi K, Saitoh Y, Kishima H. et al. Electrical stimulation of primary motor cortex within the central sulcus for intractable neuropathic pain. Clin Neurophysiol 2008; 119: 993-1001
  • 23 Huang YZ, Edwards MJ, Rounis E. et al. Theta burst stimulation of the human motor cortex. Neuron 2005; 45: 201-206
  • 24 Lefaucheur JP, Drouot X, Menard-Lefaucheur I. et al. Neurogenic pain relief by repetitive transcranial magnetic cortical stimulation depends on the origin and the site of pain. J Neurol Neurosurg Psychiatry 2004; 75: 612-616
  • 25 Khedr EM, Kotb H, Kamel NF. et al Longlasting antalgic effects of daily sessions of repetitive transcranial magnetic stimulation in central and peripheral neuropathic pain. J Neurol Neurosurg Psychiatry 2005; 76: 833-838
  • 26 Ahmed MA, Mohamed SA, Sayed D. Long-term antalgic effects of repetitive transcranial magnetic stimulation of motor cortex and serum beta-endorphin in patients with phantom pain. Neurol Res 2011; 33: 953-958
  • 27 Hosomi K, Kishima H, Oshino S. et al. Cortical excitability changes after high-frequency repetitive transcranial magnetic stimulation for central poststroke pain. Pain 2013; 154: 1352-1357
  • 28 Nardone R, Holler Y, Langthaler PB. et al. rTMS of the prefrontal cortex has analgesic effects on neuropathic pain in subjects with spinal cord injury. Spinal Cord 2017; 55: 20-25
  • 29 Lefaucheur JP, Antal A, Ayache SS. et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol 2017; 128: 56-92
  • 30 Antal A, Kriener N, Lang N. et al. Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine. Cephalalgia 2011; 31: 820-828
  • 31 Wickmann F, Stephani C, Czesnik D. et al. Prophylactic treatment in menstrual migraine: A proof-of-concept study. J Neurol Sci 2015; 354: 103-109
  • 32 Antal A, Terney D, Kuhnl S. et al. Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition. J Pain Symptom Manage 2010; 39: 890-903
  • 33 Fregni F, Boggio PS, Lima MC. et al. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 2006; 122: 197-209
  • 34 Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol 2007; 6: 188-191
  • 35 Fregni F, Gimenes R, Valle AC. et al. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum 2006; 54: 3988-3998
  • 36 Kim YJ, Ku J, Kim HJ. et al. Randomized, sham controlled trial of transcranial direct current stimulation for painful diabetic polyneuropathy. Ann Rehabil Med 2013; 37: 766-776
  • 37 Valle A, Roizenblatt S, Botte S. et al. Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial. J Pain Manag 2009; 2: 353-361
  • 38 Attal N, Ayache SS, Ciampi De Andrade D. et al. Repetitive transcranial magnetic stimulation and transcranial direct-current stimulation in neuropathic pain due to radiculopathy: a randomized sham-controlled comparative study. Pain 2016; 157: 1224-1231
  • 39 Jakobs M, Unterberg A, Treede RD. et al. Subcutaneous trigeminal nerve field stimulation for refractory trigeminal pain: a cohort analysis. Acta Neurochir (Wien) 2016; 158: 1767-1774
  • 40 Honey CM, Tronnier VM, Honey CR. Deep brain stimulation versus motor cortex stimulation for neuropathic pain: A minireview of the literature and proposal for future research. Comput Struct Biotechnol J 2016; 14: 234-237
  • 41 Rasche D, Tronnier VM. Clinical significance of invasive motor cortex stimulation for trigeminal facial neuropathic pain syndromes. Neurosurgery 2016; 79: 655-666
  • 42 Zhang X, Hu Y, Tao W. et al. The effect of motor cortex stimulation on central poststroke pain in a series of 16 patients with a mean follow-up of 28 months. Neuromodulation 2017; 20: 492-496
  • 43 Lima MC, Fregni F. Motor cortex stimulation for chronic pain: systematic review and meta-analysis of the literature. Neurology 2008; 70: 2329-2337
  • 44 Kolodziej MA, Hellwig D, Nimsky C. et al. Treatment of central deafferentation and trigeminal neuropathic pain by motor cortex Stimulation: report of a series of 20 patients. J Neurol Surg A Cent Eur Neurosurg 2016; 77: 52-58
  • 45 Fontaine D, Hamani C, Lozano A. Efficacy and safety of motor cortex stimulation for chronic neuropathic pain: critical review of the literature. J Neurosurg 2009; 110: 251-256
  • 46 Pereira EA, Green AL, Aziz TZ. Deep brain stimulation for pain. Handb Clin Neurol 2013; 116: 277-294
  • 47 Boccard SG, Pereira EA, Aziz TZ. Deep brain stimulation for chronic pain. J Clin Neurosci 2015; 22: 1537-1543