Planta Med
DOI: 10.1055/s-0043-119888
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Grincamycins I – K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32

Zhenzhu Lai1, 2, Jianchen Yu3, Huiping Ling1, Yongxiang Song2, Jie Yuan3, Jianhua Ju2, Yiwen Tao1, 4, Hongbo Huang2
  • 1School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
  • 2CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
  • 3Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
  • 4The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Further Information

Publication History

received 02 July 2017
revised 04 September 2017

accepted 14 September 2017

Publication Date:
26 September 2017 (eFirst)

Abstract

Three new angucycline glycosides, designated grincamycin I (1), J (2), and K (3), together with the known congener A-7884 (4), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC50 values ranging from 0.4 to 6.9 µM. In addition, A-7884 (4) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 µg/mL.

Supporting Information