Effect of Neuromuscular Electrical Stimulation on Brain-derived Neurotrophic Factor

Toshiaki Miyamoto; Keihou Kou; Hideya Yanamoto; Saya Hashimoto; Mai Ikawa; Takashi Sekiyama; Yoshiki Nakano; Shin-ichiro Kashiwamura; Chisako Takeda; Hiroyuki Fujioka

doi:10.1055/s-0043-120343

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2018; 39(01): 5-11
DOI: 10.1055/s-0043-120343

Physiology & Biochemistry

Effect of Neuromuscular Electrical Stimulation on Brain-derived Neurotrophic Factor

Authors

Toshiaki Miyamoto

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Keihou Kou

²School of Nursing, Hyogo University of Health Sciences, Kobe, Japan
Hideya Yanamoto

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Saya Hashimoto

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Mai Ikawa

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Takashi Sekiyama

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Yoshiki Nakano

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan
Shin-ichiro Kashiwamura

³General Education Center, Hyogo University of Health Sciences, Kobe, Japan

⁴Institute for Advanced Medical Sciences, Hyogo College of Medicine Nishinomiya, Japan
Chisako Takeda

²School of Nursing, Hyogo University of Health Sciences, Kobe, Japan
Hiroyuki Fujioka

¹School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan

Abstract

Brain-derived neurotrophic factor (BDNF) has been considered an essential mediator responsible for the beneficial effects of physical activity in preventing cognitive impairment. This study aimed at examining the effects of a single bout of neuromuscular electrical stimulation (NMES) on levels of BDNF in the plasma and on cognitive performance in healthy adult men. Thirteen healthy adult men participated in three experimental sessions. The first session was 30 min of NMES to both legs, the second was 30 min of cycling exercise at the intensity of 60% peak oxygen uptake, and the third was 30 min of complete rest. Blood was examined for plasma BDNF levels and glucose concentrations, and cognitive performance tests were performed before and after each session. A single bout of NMES significantly increased plasma BDNF levels (p<0.05), which were equivalent to the amount of plasma BDNF released during the exercise session (p>0.05). However, there were no significant changes in cognitive performance between the sessions (p>0.05). The present study found that a single bout of NMES significantly increased plasma BDNF to levels normally present during moderate voluntary exercise. Therefore, NMES could serve as an alternative method of exercise, and might shed light on individuals for whom voluntary physical exercise is contraindicated.

Key words

Electrical muscle stimulation - physical activity - cognitive function - dementia

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