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Exp Clin Endocrinol Diabetes 2019; 127(05): 320-325
DOI: 10.1055/s-0043-122881
Article
© Georg Thieme Verlag KG Stuttgart · New York

The Beneficial Effects of Trimetazidine on Reperfusion–Induced Arrhythmia in Diabetic Rats

Fatemeh Ramezani-Aliakbari
1   Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
,
Mohammad Badavi
1   Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
2   Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
3   Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
,
Mahin Dianat
1   Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
2   Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
,
Seyed Ali Mard
1   Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
2   Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
,
Akram Ahangarpour
1   Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
2   Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran
4   Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran
› Author Affiliations
Further Information

Publication History

received 06 August 2017
revised 22 October 2017

accepted 13 November 2017

Publication Date:
05 March 2018 (online)

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Abstract

Trimetazidine (TMZ), as an anti-ischemic drug, plays a critical role in protecting against cardiovascular complications induced by diabetes. This study was therefore aimed to evaluate the protective effects of TMZ on reperfusion-induced arrhythmias in the diabetic rats. Male Sprague-Dawley rats (250±20 g) were randomly assigned to four (n=8): control rats (C), alloxan induced diabetic rats (D), diabetic rats treated with TMZ (10 mg/kg, D+T10), diabetic rats treated with TMZ (30 mg/kg, D+T30). TMZ was treated orally once daily for 8 weeks. Diabetes was induced by a single intraperitoneal injection of alloxan (120 mg/kg). Ischemia-reperfusion (I/R) was carried out via 30 min of ischemia and following120-min reperfusion. The magnitude and score of arrhythmia, the left ventricular function, infarct size, lactate dehydrogenase (LDH), myocardial creatine kinase (CK-MB) and troponin (cTnI) were measured. The findings were evaluated by two-way repeated measures and one-way ANOVA followed by LSD post hoc test and Fisher's exact test for incidence percentage. The duration, incidence and score of arrhythmia (p<0.001), infarct size (p<0.01) were significantly increased, the cardiac contractility (±dp/dt), LDH, CK-MB (p<0.001) and cTnI (p<0.05) were significantly decreased in the diabetic rats in comparison with the control group. However, treatment with TMZ in the diabetic rats was significantly improved the duration (p<0.001), incidence and score of arrhythmia,±dp/dt LDH, CK-MB, cTnI (p<0.05) and infarct size (p<0.01) in comparison with the untreated diabetic group. The present study indicates anti-arrhythmic effect of TMZ in reducing arrhythmias induced by reperfusion in the diabetic rats.

Key words

diabetes - trimetazidine - arrhythmia - reperfusion - rats
 

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