Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

Khalid Siddiqui; Khalid Al-Rubeaan; Shaik Sarfaraz Nawaz; Khaled H. Aburisheh; Anas M. Zein Alaabdin; Ibrahim A. Tolba

doi:10.1055/s-0043-123348

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2018; 50(02): 138-144
DOI: 10.1055/s-0043-123348

Endocrine Care

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

Authors

Khalid Siddiqui

¹Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Khalid Al-Rubeaan

¹Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia

²University Diabetes Center, King Saud University, College of Medicine, Riyadh, Riyadh Province, Saudi Arabia
Shaik Sarfaraz Nawaz

¹Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Khaled H. Aburisheh

²University Diabetes Center, King Saud University, College of Medicine, Riyadh, Riyadh Province, Saudi Arabia
Anas M. Zein Alaabdin

²University Diabetes Center, King Saud University, College of Medicine, Riyadh, Riyadh Province, Saudi Arabia
Ibrahim A. Tolba

²University Diabetes Center, King Saud University, College of Medicine, Riyadh, Riyadh Province, Saudi Arabia

Abstract

Sex hormone binding globulin (SHBG) is demonstrated to be decreased in subjects with metabolic syndrome (MetS). The aim of the present study was to investigate the association of SHBG in relation to MetS components among men with type 2 diabetes (T2D). This cross-sectional study was carried out among 429 Saudi T2D male patients aged >30 years. Metabolic syndrome was defined using International Diabetes Federation (IDF) criteria. Fasting blood glucose (FBG), HbA1c, albumin, and lipid parameter were measured. Gonadal hormones, namely total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and SHBG were determined using ELISA. The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013. As the MetS score increases, SHBG and HDL levels decrease while weight, BMI, waist circumference, SBP, DBP, FBG, HbA1c, TC, and TG levels increase. SHBG correlated with age, BMI, TG, HDL, TT, free testosterone, and bio-available testosterone. This is the first study that provides detailed analyses of SHBG with MetS components in male diabetic subjects. The mean serum SHBG levels gradually declined with the addition of MetS components in T2D men. TT, free testosterone, and bio-available testosterone remained independently associated with SHBG by multivariable regression analysis.

Key words

sex hormone binding globulin - type 2 diabetes - metabolic syndrome - total testosterone

Full Text

References

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