Planta Med 2018; 84(08): 536-543
DOI: 10.1055/s-0043-123655
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

A Simple and Rapid UPLC-PDA Method for Quality Control of Nardostachys jatamansi

Weize Zhang
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Guo Nan
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Hong-Hua Wu
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Miaomiao Jiang
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Tian-Xiang Li
2   Chinese Medicine Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Meng Wang
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Xiu-Mei Gao
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Yan Zhu
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Yun Seon Song
3   College of Pharmacy, Sookmyung Womenʼs University, Seoul, Korea
,
Jiaming Wang
4   Key Laboratory of Industrial Fermentation Microbiology Ministry of Education, Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, P. R. China
,
Yan-Tong Xu
1   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 12. Mai 2017
revised 09. November 2017

accepted 17. November 2017

Publikationsdatum:
04. Dezember 2017 (online)

Abstract

Nardostachys jatamansi is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of N. jatamansi. Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of N. jatamansi and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in N. jatamansi. For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of N. jatamansi samples from different retail sources. Six of the common peaks (5, 7, 12, and 16 – 18) were identified as desoxo-narchinol A, buddleoside, isonardosinone, nardosinone, kanshone H, and (−)-aristolone, respectively, by phytochemical investigation. Five of the six compounds significantly either enhanced or inhibited serotonin transporter activity, while (−)-aristolone (18) didnʼt show any serotonin transporter activity. In quantitative analysis, the six compounds showed good linearity (r > 0.999) within test ranges. The precision, expressed as relative standard deviation, was in the range of 0.25 – 2.77%, and the recovery of the method was in the range of 92 – 105%. The UPLC-photodiode array detection-based fingerprint analysis and quantitative methods reported here could be used for routine quality control of N. jatamansi.

Supporting Information

 
  • References

  • 1 The State Pharmacopoeia Commission of the Peopleʼs Republic of China. Pharmacopoeia of the Peopleʼs Republic of China, Vol. 1. Beijing: China Medical Pharmaceutical Science and Technology Publishing House; 2015: 86
  • 2 Shang XF, Tao CX, Miao XL, Wang DS, Dawa T, Wang Y, Yang YG, Pan H. Ethno-veterinary survey of medicinal plants in Ruoergai region, Sichuan province, China. J Ethnopharmacol 2012; 142: 390-400
  • 3 Subashini R, Ragavendran B, Gnanapragasam A, Yogeeta SK, Devaki T. Biochemical study on the protective potential of Nardostachys jatamansi extract on lipid profile and lipid metabolizing enzymes in doxorubicin intoxicated rats. Pharmazie 2007; 62: 382-387
  • 4 Bae GS, Kim MS, Park KC, Koo BS, Jo IJ, Choi SB, Lee DS, Kim YC, Kim TH, Seo SW, Shin YK, Song HJ, Park SJ. Effect of biologically active fraction of Nardostachys Jatamansi on cerulein-induced acute pancreatitis. Word J Gastroenterology 2012; 18: 3223-3234
  • 5 Rahman H, Shaik HA, Madhavi P, Eswaraiah MC. A review: pharmacognostics and pharmacological profiles of Nardastachys jatamansi DC. Elixir Pharmacy 2011; 39: 5017-5020
  • 6 Tanitsu MA, Takaya Y, Akasaka M, Niwa M, Oshima Y. Guaiane- and aristolane-type sesquiterpenoids of Nardostachys chinensis roots. Phytochemistry 2002; 59: 845-849
  • 7 Zhang Y, Lu Y, Zhang L, Zheng QT, Xu LZ, Yang SL. Terpenoids from the roots and rhizomes of Nardostachys chinensis . J Nat Prod 2005; 68: 1131-1133
  • 8 Deng X, Wu YJ, Chen YP, Zheng HH, Wang ZP, Zhu Y, Gao XM, Xu YT, Wu HH. Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal. Bioorg Med Chem Lett 2017; 27: 875-879
  • 9 Wu HH, Chen YP, Ying SS, Zhang P, Xu YT, Gao XM, Zhu Y. Dinardokanshones A and B, two unique sesquiterpene dimers from the roots and rhizomes of Nardostachys chinensis . Tetrahedron Lett 2015; 56: 5851-5854
  • 10 Wang FJ, Liu S, Luo MY, Qin Y, Lei P, Liu YH, Liang YZ. Analysis of essential oil of Nardostachys chinensis Batal. by GC-MS combined with chemometric techniques. Acta Chromatographica 2015; 27: 157-175
  • 11 Li YM, Liu GL, Qiao J, Liu S, Zhang Y, Qin ZX, Liu Y. Simultaneous determination of chlorogenic acid and nardosinone in Nardostachys chinensis DC. from different producing areas by HPLC. Inf Tradit Chin Med 2015; 32: 27-30
  • 12 Lu ZH, Zhou P, Zhan YZ, Su JR, Yi DL. Quantification of nardosinone in rat plasma using liquid chromatography-tandem mass spectrometry and its pharmacokinetics application. J Chromatogr Sci 2015; 53: 1725-1729
  • 13 Divakaran R, Philip MP, Lakshmanan AJ, Sadanandan K, Murugesan M, Somanathan AR, Bayamma KV, Damodaran NP. Standardization of ayurvedic medicines – 1: single plant drugs, part 1 – gas chromatographic profiles as an approach to fingerprint standards for oil-bearing drugs. Indian Drugs 1985; 23: 5-12
  • 14 Mallavadhani UV, Panigrahi R, Pattnaik B. A rapid and highly sensitive UPLC-QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker. Biomed Chromatogr 2011; 25: 902-907
  • 15 Parekh A, Jadhav VM. Development of validated HPTLC method for quantification of jatamansone in jatamansi oil. J Pharm Sci 2009; 2: 975-977
  • 16 Srivastava A, Tiwari SS, Srivastava S, Rawat AKS. HPTLC method for quantification of valerenic acid in Ayurvedic drug Jatamansi and its substitutes. J Liq Chromatogr Relat Technol 2010; 33: 1679-1688
  • 17 Thorat RM, Jadhav VM, Kadam VJ, Kamble SS, Salaskar KP. Development of HPTLC method for estimation of wedelolactone, quercetin and jatamansone in polyherbal formulations. Int J ChemTech Res 2009; 1: 1079-1086
  • 18 Drug Administration. Bureau of China, Requirements for Studying Fingerprint of Traditional Chinese Injections (Draft). Shanghai: Drug Administration; 2000
  • 19 World Health Organization. General Guidelines for Methodologies on Research and Evaluation of traditional Medicines. Geneva: WHO; 2000
  • 20 Itokawa H, Masuyama K, Morita H, Takeya K. Cytotoxic sesquiterpenes from Nardostachys chinensis . Chem Pharm Bull 1993; 41: 1183-1184
  • 21 Bagchi A, Oshima Y, Hikino H. Neolignans and lignans of Nardostachys jatamansi roots. Planta Med 1991; 57: 96-97
  • 22 Bagchi A, Oshima Y, Hikino H. Kanshones D and E, sesquiterpenoids of Nardostachys chinensis roots. Phytochemistry 1988; 27: 3667-3669
  • 23 Liu ML, Duan YH, Zhang JB, Yu Y, Dai Y, Yao XS. Novel sesquiterpenes from Nardostachys chinensis Batal. Tetrahedron 2013; 69: 6574-6578
  • 24 Su H, Shi DY, Li J, Guo SJ, Li LL, Yuan ZH, Zhu XB. Sesquiterpenes from Laurencia similis . Molecules 2009; 14: 1889-1897
  • 25 Han Y, Wen J, Zhou TT, Fan GR. Chemical fingerprinting of Gardenia jasminoides Ellis by HPLC-DAD-ESIMS combined with chemometrics methods. Food Chem 2015; 188: 648-657
  • 26 Zhang X, Hu XM, Luo X, Fu CM, Li Y, Wang S. Determination of acaciin in Nardostachys chinenesis Batal by HPLC. West China J Pharm Sci 2007; 22: 690-692
  • 27 Chen YP, Ying SS, Zheng HH, Liu YT, Wang ZP, Zhang H, Deng X, Wu YJ, Gao XM, Li TX, Zhu Y, Xu YT, Wu HH. Novel serotonin transporter regulators: Natural aristolane- and nardosinane- types of sesquiterpenoids from Nardostachys chinensis Batal. Sci Rep 2017; 7: 15114
  • 28 Zhang JB, Liu ML, Li C, Zhang Y, Dai Y, Yao XS. Nardosinane-type sesquiterpenoids of Nardostachys chinensis Batal. Fitoterapia 2015; 100: 195-200