Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Dao Ngoc Hien Tam; Duy Hieu Truong; Thi Thanh Hoa Nguyen; Le Nhat Quynh; Linh Tran; Hong Duong Nguyen; Bahaa eldin Shamandy; Thi Minh Huong Le; Dang Khoa Tran; Dina Sayed; Van Vinh Vu; Shusaku Mizukami; Kenji Hirayama; Nguyen Tien Huy

doi:10.1055/s-0043-124087

Planta Medica, Table of Contents

Planta Med 2018; 84(03): 139-152
DOI: 10.1055/s-0043-124087

Reviews

Georg Thieme Verlag KG Stuttgart · New York

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Authors

Dao Ngoc Hien Tam^*

¹Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
Duy Hieu Truong^*

²Institute of Research and Development, Duy Tan University, Da Nang, Vietnam
Thi Thanh Hoa Nguyen

³Huy Cuong Pharmaceutical Company, Ho Chi Minh City, Vietnam
Le Nhat Quynh

⁴Hue University of Medicine and Pharmacy, Hue, Vietnam
Linh Tran

²Institute of Research and Development, Duy Tan University, Da Nang, Vietnam
Hong Duong Nguyen

⁵Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan
Bahaa eldin Shamandy

⁶Faculty of Medicine, Aswan University, Aswan, Egypt
Thi Minh Huong Le

⁷Tien Giang General Hospital, Tien Giang, Vietnam
Dang Khoa Tran

⁸Vo Truong Toan University, Hau Giang, Vietnam
Dina Sayed

⁹Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt
Van Vinh Vu

¹⁰School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea
Shusaku Mizukami

¹¹Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Kenji Hirayama

¹¹Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Nguyen Tien Huy

¹²Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam

¹³Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

Abstract

Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

Key words

ginsenoside Rh1 - Panax ginseng - Araliaceae - in vitro - in vivo

Full Text

References

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