Klinische Neurophysiologie 2018; 49(01): 30-40
DOI: 10.1055/s-0043-125299
Originalia
© Georg Thieme Verlag KG Stuttgart · New York

Critical Care EEG: Möglichkeiten und Limitationen

Critical Care EEG: Possibilities and Limitations
Johannes Koren
1   Karl Landsteiner Institut für Klinische Epilepsieforschung und Kognitive Neurologie, Neurologische Abteilung, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wien
,
Johannes Herta
2   Universitätsklinik für Neurochirurgie, Medizinische Universität Wien, Wien
,
Christoph Baumgartner
1   Karl Landsteiner Institut für Klinische Epilepsieforschung und Kognitive Neurologie, Neurologische Abteilung, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wien
3   Abteilung für Epileptologie und Klinische Neurophysiologie, Sigmund Freud Universität, Wien
› Author Affiliations
Further Information

Publication History

Publication Date:
17 January 2018 (online)

Zusammenfassung

Unklare quantitative und qualitative Bewusstseinsstörungen, nicht-konvulsive Anfälle und Status epileptici sowie Sedierungs- und Therapiemanagement sind Indikationen für die Anwendung von kontinuierlichem EEG Monitoring auf der Intensivstation. Durch technologische und wissenschaftliche Fortschritte gewinnt das Neuromonitoring mittels EEG bei intensivpflichtigen Patienten in den letzten Jahren immer mehr an Bedeutung und kommt immer häufiger zur Anwendung. Aufgrund des hohen personellen und technischen Aufwandes, in Zeiten begrenzter Ressourcen, ist ein pragmatisches Vorgehen bei der Indikationsstellung notwendig. Dies gilt v. a. auf neurologischen Intensivstationen, wo metabolische, ischämische, entzündliche, traumatische und strukturelle Hirnschädigungen besonders oft eine differenzialdiagnostische Abklärung mittels EEG verlangen. Im Rahmen dieses Artikels soll die aktuelle Literatur, wie auch wichtige pathologische EEG Muster anhand von Beispielen übersichtlich dargestellt werden.

Abstract

Continuous EEG in the intensive care unit should be used for diagnosis of unclear deterioration in consciousness, nonconvulsive seizures and epileptic status as well as management of therapeutic sedation. Due to recent technologic and scientific advances, continuous EEG is more frequently used. However, because of the need for high personnel and technologic resources, a pragmatic approach regarding the use of continuous EEG is necessary. This is especially true in neurological intensive care units, because many patients with metabolic, ischemic, inflammatory, traumatic and structural brain damage/lesions require evaluation with EEG. We focus in this review on the recent literature regarding EEG evaluation in critical care patients. We illustrate important pathologic EEG patterns with examples.

 
  • Literatur

  • 1 Chong DJ, Hirsch LJ. Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns. J Clin Neurophysiol 2005; 22: 79-91
  • 2 Sutter R, Kaplan PW. Electroencephalographic criteria for nonconvulsive status epilepticus: synopsis and comprehensive survey. Epilepsia 2012; 53 (Suppl. 03) 1-51
  • 3 Trinka E, Leitinger M. Which EEG patterns in coma are nonconvulsive status epilepticus?. Epilepsy Behav 2015; 49: 203-222
  • 4 Rodriguez Ruiz A, Vlachy J, Lee JW. et al. Association of periodic and rhythmic electroencephalographic patterns with seizures in critically ill patients. JAMA Neurol 2017; 74: 181-188
  • 5 Hirsch LJ, LaRoche SM, Gaspard N. et al. American Clinical Neurophysiology Society's Standardized critical care EEG terminology: 2012 version. J Clin Neurophysiol 2013; 30: 1-27
  • 6 Herman ST, Abend NS, Bleck TP. et al. Consensus statement on continuous EEG in critically ill adults and children, part I: indications. J Clin Neurophysiol 2015; 32: 87-95
  • 7 Herman ST, Abend NS, Bleck TP. et al. Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice. J Clin Neurophysiol 2015; 32: 96-108
  • 8 Alroughani R, Javidan M, Qasem A. et al. Non-convulsive status epilepticus; the rate of occurrence in a general hospital. Seizure 2009; 18: 38-42
  • 9 Altindag E, Okudan ZV, Tavukcu Ozkan S. et al. Electroencephalographic patterns recorded by continuous eeg monitoring in patients with change of consciousness in the neurological intensive care unit. Noro Psikiyatr Ars 2017; 54: 168-174
  • 10 Claassen J, Albers D, Schmidt JM. et al. Nonconvulsive seizures in subarachnoid hemorrhage link inflammation and outcome. Ann Neurol 2014; 75: 771-781
  • 11 Claassen J, Mayer SA, Kowalski RG. et al. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 2004; 62: 1743-1748
  • 12 Claassen J, Perotte A, Albers D. et al. Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomes. Ann Neurol 2013; 74: 53-64
  • 13 Crepeau AZ, Kerrigan JF, Gerber P. et al. Rhythmical and periodic EEG patterns do not predict short-term outcome in critically ill patients with subarachnoid hemorrhage. J Clin Neurophysiol 2013; 30: 247-254
  • 14 DeLorenzo RJ, Waterhouse EJ, Towne AR. et al. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 1998; 39: 833-840
  • 15 Dennis LJ, Claassen J, Hirsch LJ. et al. Nonconvulsive status epilepticus after subarachnoid hemorrhage. Neurosurgery 2002; 51: 1136-1143 discussion 1144
  • 16 Gaspard N, Manganas L, Rampal N. et al. Similarity of lateralized rhythmic delta activity to periodic lateralized epileptiform discharges in critically ill patients. JAMA Neurol 2013; 70: 1288-1295
  • 17 Husain AM, Horn GJ, Jacobson MP. Non-convulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG. J Neurol Neurosurg Psychiatry 2003; 74: 189-191
  • 18 Jordan KG. Continuous EEG and evoked potential monitoring in the neuroscience intensive care unit. J Clin Neurophysiol 1993; 10: 445-475
  • 19 Koren J, Herta J, Draschtak S. et al. Prediction of rhythmic and periodic EEG patterns and seizures on continuous EEG with early epileptiform discharges. Epilepsy Behav 2015; 49: 286-289
  • 20 Koren JP, Herta J, Pirker S. et al. Rhythmic and periodic EEG patterns of 'ictal-interictal uncertainty' in critically ill neurological patients. Clin Neurophysiol 2016; 127: 1176-1181
  • 21 Kurtz P, Gaspard N, Wahl AS. et al. Continuous electroencephalography in a surgical intensive care unit. Intensive Care Med 2014; 40: 228-234
  • 22 Lorenzl S, Mayer S, Feddersen B. et al. Nonconvulsive status epilepticus in palliative care patients. J Pain Symptom Manage 2010; 40: 460-465
  • 23 Naeije G, Depondt C, Meeus C. et al. EEG patterns compatible with nonconvulsive status epilepticus are common in elderly patients with delirium: a prospective study with continuous EEG monitoring. Epilepsy Behav 2014; 36: 18-21
  • 24 Seidel S, Aull-Watschinger S, Pataraia E. The yield of routine electroencephalography in the detection of incidental nonconvulsive status epilepticus--a prospective study. Clin Neurophysiol 2012; 123: 459-462
  • 25 Swisher CB, Shah D, Sinha SR. et al. Baseline EEG pattern on continuous ICU EEG monitoring and incidence of seizures. J Clin Neurophysiol 2015; 32: 147-151
  • 26 Towne AR, Waterhouse EJ, Boggs JG. et al. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000; 54: 340-345
  • 27 Vespa PM, O'Phelan K, Shah M. et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology 2003; 60: 1441-1446
  • 28 Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996; 47: 83-89
  • 29 Holtkamp M, Meierkord H. Nonconvulsive status epilepticus: a diagnostic and therapeutic challenge in the intensive care setting. Ther Adv Neurol Disord 2011; 4: 169-181
  • 30 Sutter R, Semmlack S, Kaplan PW. Nonconvulsive status epilepticus in adults - insights into the invisible. Nat Rev Neurol 2016; 12: 281-293
  • 31 Beniczky S, Hirsch LJ, Kaplan PW. et al. Unified EEG terminology and criteria for nonconvulsive status epilepticus. Epilepsia 2013; 54 (Suppl. 06) 28-29
  • 32 Leitinger M, Beniczky S, Rohracher A. et al. Salzburg consensus criteria for non-convulsive status epilepticus–approach to clinical application. Epilepsy Behav 2015; 49: 158-163
  • 33 Ferguson M, Bianchi MT, Sutter R. et al. Calculating the risk benefit equation for aggressive treatment of non-convulsive status epilepticus. Neurocrit Care 2013; 18: 216-227
  • 34 Accolla EA, Kaplan PW, Maeder-Ingvar M. et al. Clinical correlates of frontal intermittent rhythmic delta activity (FIRDA). Clin Neurophysiol 2011; 122: 27-31
  • 35 Kaplan PW. Assessing the outcomes in patients with nonconvulsive status epilepticus: nonconvulsive status epilepticus is underdiagnosed, potentially overtreated, and confounded by comorbidity. J Clin Neurophysiol 1999; 16: 341-352 discussion 353
  • 36 Kaplan PW. No, some types of nonconvulsive status epilepticus cause little permanent neurologic sequelae (or: "the cure may be worse than the disease"). Neurophysiol Clin 2000; 30: 377-382
  • 37 Sutter R, Marsch S, Fuhr P. et al. Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology 2014; 82: 656-664
  • 38 Trinka E, Hofler J, Leitinger M. et al. Pharmacologic treatment of status epilepticus. Expert Opin Pharmacother 2016; 17: 513-534
  • 39 Foreman B, Claassen J. Quantitative EEG for the detection of brain ischemia. Crit Care 2012; 16: 216
  • 40 Finnigan S, van Putten MJ. EEG in ischaemic stroke: quantitative EEG can uniquely inform (sub-)acute prognoses and clinical management. Clin Neurophysiol 2013; 124: 10-19
  • 41 Herta J, Koren J, Furbass F. et al. Reduced electrode arrays for the automated detection of rhythmic and periodic patterns in the intensive care unit: Frequently tried, frequently failed?. Clin Neurophysiol 2017; 128: 1524-1531
  • 42 Friedman D, Claassen J, Hirsch LJ. Continuous electroencephalogram monitoring in the intensive care unit. Anesth Analg 2009; 109: 506-523
  • 43 Machado C, Estevez M, Carrick F. et al. qEEG may increase the reliability of diagnostic and prognostic procedures in cerebral arterial gas embolism. Clin Neurophysiol 2012; 123: 225-226
  • 44 Nuwer M. Assessment of digital EEG, quantitative EEG, and EEG brain mapping: report of the American Academy of Neurology and the American Clinical Neurophysiology Society. Neurology 1997; 49: 277-292
  • 45 Nuwer MR. Assessing digital and quantitative EEG in clinical settings. J Clin Neurophysiol 1998; 15: 458-463
  • 46 Furbass F, Hartmann MM, Halford JJ. et al. Automatic detection of rhythmic and periodic patterns in critical care EEG based on American Clinical Neurophysiology Society (ACNS) standardized terminology. Neurophysiol Clin 2015; 45: 203-213
  • 47 Herta J, Koren J, Furbass F. et al. Prospective assessment and validation of rhythmic and periodic pattern detection in NeuroTrend: A new approach for screening continuous EEG in the intensive care unit. Epilepsy Behav 2015; 49: 273-279
  • 48 Herta J, Koren J, Furbass F. et al. Applicability of NeuroTrend as a bedside monitor in the neuro ICU. Clin Neurophysiol 2017; 128: 1000-1007
  • 49 Foreman B, Claassen J, Abou Khaled K. et al. Generalized periodic discharges in the critically ill: a case-control study of 200 patients. Neurology 2012; 79: 1951-1960
  • 50 Reiher J, Rivest J, Grand'Maison F. et al. Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures. Electroencephalogr Clin Neurophysiol 1991; 78: 12-17
  • 51 Brigo F. Intermittent rhythmic delta activity patterns. Epilepsy Behav 2011; 20: 254-256
  • 52 Trinka E, Cock H, Hesdorffer D. et al. A definition and classification of status epilepticus–Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 2015; 56: 1515-1523