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Eur J Pediatr Surg 2023; 33(03): 255
DOI: 10.1055/s-0043-1767791
Letter to the Editor

Response to: Endoscopic Injections of Botulinum Toxin Type A in the Piglet Esophagus Is Safe and Feasible but Did Not Result in any Significant Structural Changes 3 Days after Injection

Morten Rose
1   Department of Surgery, Odense University Hospital, Odense, Syddanmark, Denmark
,
Patrick Clarke
2   Department of Surgery, University of Vermont Larner College of Medicine, Burlington, Vermont, United States
,
Ashton H. Pike
2   Department of Surgery, University of Vermont Larner College of Medicine, Burlington, Vermont, United States
,
Peter Zvara
3   Department of Clinical Research, University of Southern Denmark, Odense, Syddanmark, Denmark
,
Henrik D. Schrøder
4   Department of Clinical Pathology, Odense University Hospital, Odense, Syddanmark, Denmark
,
Eva K. Hejboel
4   Department of Clinical Pathology, Odense University Hospital, Odense, Syddanmark, Denmark
,
Niels Qvist
1   Department of Surgery, Odense University Hospital, Odense, Syddanmark, Denmark
,
Mark B. Ellebæk
1   Department of Surgery, Odense University Hospital, Odense, Syddanmark, Denmark
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Comment on:

Endoscopic Injections of Botulinum Toxin Type A in the Piglet Esophagus Is Safe and Feasible but Did Not Result in any Significant Structural Changes 3 Days after InjectionEur J Pediatr Surg 2022; 32(05): 460-464
DOI: 10.1055/s-0042-1745783

Endoscopic Injections of Botulinum Toxin Type A in the Piglet Esophagus Is Safe and Feasible but Did Not Result in any Significant Structural Changes 3 Days after Injection

Endoscopic Injections of Botulinum Toxin Type A in the Piglet Esophagus Is Safe and Feasible but Did Not Result in any Significant Structural Changes 3 Days after Injection

Thank you for your interest in our project and for this important comment. We completely agree that a longer waiting period needs to be examined. Nonetheless, there is an “acute” effect of Botulinum toxin with reductions of muscle strength,[1] and the aim of our study was to evaluate this. We have also, in previous articles, shown that a significant increase in elongation of the esophagus could be achieved already after 1 hour.[2] We do agree that an investigation after 1 to 2 weeks would be very relevant, and we are conducting further experimental studies to see if that makes a difference. We chose to study the “acute” effect because this might be interesting from a clinical perspective, but we do agree that a waiting period for 1 to 2 weeks to esophageal reconstruction after Botulinum injection should be no major problem if our ongoing studies show a more pronounced effect.



Publication History

Received: 06 February 2023

Accepted: 06 February 2023

Article published online:
05 April 2023

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  • References

  • 1 Croes SA, Baryshnikova LM, Kaluskar SS, von Bartheld CS. Acute and long-term effects of botulinum neurotoxin on the function and structure of developing extraocular muscles. Neurobiol Dis 2007; 25 (03) 649-664 DOI: 10.1016/j.nbd.2006.11.007. Epub 2007 Jan 10. PMID: 17222559; PMCID: PMC1855088.
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  • 2 Larsen HF, Jensen TS, Rasmussen L, Ellebæk M, Qvist N. Intramural injection with botulinum toxin significantly elongates the pig esophagus. J Pediatr Surg 2013; 48 (10) 2032-2035 DOI: 10.1016/j.jpedsurg.2013.03.062.. PMID: 24094953.
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