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DOI: 10.1055/s-0043-1768631
Deciphering the Patterns of Dual Primary Cases Registered at the Hospital-Based Cancer Registry: First Experience from Rural Cancer Center in North India
Abstract
Objectives The objective is to present the patterns of dual primary malignancies diagnosed at the Pathology Laboratory of Cancer Hospital with the support from hospital-based cancer registry (HBCR), Sangrur, Punjab, India for the years 2018 and 2019.
Methods HBCR abstracts data from electronic medical records. Trained cancer registry staff abstracts cases in standard pro forma. Dual primary was coded as per the International Agency for Research on Cancer rule and was rechecked by the pathologist.
Statistical Analysis Data about multiple primary was entered and documented in an Excel sheet. Time interval was calculated by subtracting the date of diagnosis for second primary and first primary.
Results A total of 6,933 cases were registered, 45 cases are dual primary (26 females, 19 males) of which 64.4% are synchronous and 35.6% metachronous cases. Seventy-nine percent received cancer-directed treatment for synchronous and 87% for metachronous. The most common sites of the primary tumor were breast (33%), head and neck (22.2%), gynecological sites (11%), prostate (9%), esophagus (4%), and remaining other tumors (20.8%). Most common sites for second malignancies were gastrointestinal (GI) tract (31%), gynecological sites (18%), head and neck (16%), hematological malignancies (7%), soft tissue sarcoma (4%), breast (2%), and other sites (22%).
Conclusion More than 70% of cases of primary tumors were in breast, head and neck, gynecological, and prostate. Of these, more than 60% of the second malignancy was found in the GI tract, gynecological, and head and neck sites. Around two-thirds of dual tumors are synchronous. Breast cancer cases have higher incidence of second malignancy. Regular follow-up is necessary to assess the survival of the second primary.
Authors' Contributions
S.S.: Conceptualization, methodology, pathology inputs, writing the original draft.
A.K.G.: Conceptualization, clinical inputs, assistance in writing the draft.
A.S.: Conceptualization, clinical inputs, assistance in writing the draft.
K.S.C.: Data collection, data quality control, data abstraction, assistance in writing the draft.
K.A.: Data collection, data quality control, data abstraction, assistance in writing the draft.
D.C.: Conceptualization, clinical inputs, assistance in writing the draft.
T.D.: Conceptualization, clinical inputs, assistance in writing the draft.
S.T.: Conceptualization, clinical inputs, assistance in writing the draft.
P.K.: Data collection, data quality control, data abstraction, assistance in writing the draft.
P.J.: Data collection, data quality control, data abstraction, assistance in writing the draft.
A.S.: Conceptualization, pathological inputs, assistance in writing draft.
R.S.B.: Radiologist, assistance in writing the draft.
A.B.: Conceptualization, methodology, data analysis, overall supervision, writing the original draft.
A.G.: Conceptualization, clinical inputs, assistance in writing the draft, overall supervision.
J.V.D.: Conceptualization, clinical inputs, assistance in writing the draft, overall supervision.
R.A.B.: Conceptualization, supervision, technical guidance, clinical inputs, and valuable criticism on the write-up.
Publication History
Received: 26 December 2022
Accepted: 13 March 2023
Article published online:
12 May 2023
© 2023. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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