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CC BY 4.0 · Indian J Med Paediatr Oncol 2025; 46(03): 327-331
DOI: 10.1055/s-0043-1770904
Case Report with Review of Literature

Isolated Cerebral Metachronous Metastasis in Fibular Osteosarcoma: A Rare Case Report with Review of Literature

Authors

  • Manoj Kumar Nayak 

    1   Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

  • Sameer Rastogi

    2   Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India

  • Leve Joseph Sebastian 

    1   Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

  • Ghazal Tansir 

    2   Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India

  • Anubhav Narwal 

    3   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Funding None.
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Abstract

Isolated brain involvement is rarely reported as isolated metachronous metastasis from osteosarcoma. Herein, we report a case of fibular osteosarcoma in a young female who presented with solitary hemorrhagic metachronous cerebral metastasis after years of disease-free interval. Imaging showed a large mass lesion in the right posterior temporal lobe with internal areas of bleed not associated with calcification or ossification mimicking high-grade glioma. No other sites of distant metastases were found on the workup. Two-dimensional echocardiography was done to rule out any cardiac anomaly, including the shunt defect, but no abnormality was detected. She was operated for the cerebral lesion, and histopathology of the resected specimen showed osteosarcoma. The patient was started on chemotherapy and is doing well so far. This case presents a unique scenario of osteosarcoma with an isolated lesion in the brain without any other site of distant metastasis.

Keywords

osteosarcoma - brain metastasis - high-grade glioma - lung metastasis

Authors' Contributions

M.K.N. and S.R. designed and wrote the manuscript. A.N. provided the histopathology and images. S.L.J., G.T., S.R., A.N., and M.K.N. critically reviewed and revised the manuscript. Finally, all the authors have read and approved the manuscript. The requirements for authorship have been met, and that each author believes that the manuscript represents honest work.


Patient Consent

The authors certify that the appropriate consent forms were taken from the patient. In the consent, she had given the consent for the images and clinical information to be reported to this journal. The patient understands that her name and identity will not be disclosed but anonymity cannot be guaranteed.




Publication History

Article published online:
27 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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