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CC BY 4.0 · Indian Journal of Neurosurgery 2023; 12(02): 163-167
DOI: 10.1055/s-0043-1771448
Original Article

Intraoperative Squash Cytology and Histopathological Correlation of Glial Tumors at a Tertiary Care Hospital

Diya Bajaj
1   Department of Neuropathology, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Lekha Ramchandani
1   Department of Neuropathology, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Shamim Ansari
1   Department of Neuropathology, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Nishtha Yadav
2   Department of Neuroradiology, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Jitin Bajaj 
,
Shailendra Ratre
3   Department of Neurosurgery, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Vijay Parihar
3   Department of Neurosurgery, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
M. Narayan Swamy
3   Department of Neurosurgery, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
,
Yad Ram Yadav 
3   Department of Neurosurgery, Super-Speciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh, India
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Abstract

Introduction Central nervous system (CNS) tumors account for around 1 to 2% of all neoplasms, commonest of them being gliomas. Gliomas constitute a large, heterogenous group of tumors known for a wide variation in clinical presentation, gross and microscopic features, and biologic behavior. Squash cytology can be a great asset in the intraoperative diagnosis of CNS pathology. In this article, we correlate it with the histopathology of gliomas.

Methods A prospective analytical study was conducted at the Department of Neuropathology, Super-Speciality Hospital, NSCB Medical College, Jabalpur, India. A total of 75 samples were collected for intraoperative squash cytology. The biopsy samples were collected subsequently after surgery for histopathological correlation. Statistical analysis was done using SPSS software to calculate the sensitivity, specificity, and diagnostic accuracy of squash cytology.

Results Of the total 75 patients clinically and radiologically suspected of having gliomas, 43 (57.33%) were males to give a male-to-female ratio of 1.34:1. The mean age at presentation was 36.50 ± 16.87 years. Right-sided tumors were more common. The most common location was the frontal lobe (46.66%). Concordance with squash cytology was found in 81.33% of cases. Sensitivity, specificity, and diagnostic accuracy of squash cytology in the diagnosis of gliomas were found to be 98.61, 66.66, and 97.33%, respectively.

Conclusion Squash cytology is a rapid, inexpensive, and accurate diagnostic method for intraoperative diagnosis of gliomas that can guide the surgeon on the extent of tumor resection.

Keywords

glioma - cytology - histopathology - intraoperative - squash


Publication History

Article published online:
26 July 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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