Abstract
Purnima Thakur
This study aimed to identify the prognostic factors affecting the survival of patients
suffering from Krukenberg tumor (KT) and also to determine the survival in these patients.
A retrospective review of patients diagnosed with KT between January 2015 and December
2021 was conducted at a tertiary cancer center. Clinicopathological variables were
scrutinized, and survival analysis was performed. Thirty-six patients were enrolled
in this study. The median age at diagnosis was 48 years (ranging from 22 to 71 years).
The median overall survival (OS) was 9.9 months (95% confidence interval [CI]: 6.6
to 13 months). The mean OS for tumors originating in the colorectal region was longer
compared to that for tumors of other sites (15.4 vs. 9 months, respectively; p = 0.048). In univariate analysis, patients who received chemotherapy had better survival,
while those presenting with ascites had a poor prognosis. No correlation was observed
between age, menstrual status, bilaterality, size of ovarian metastases, extent of
metastatic disease, metastasectomy, and survival. Multivariate Cox regression analysis
showed that chemotherapy predicted a favorable survival outcome (hazard ratio [HR] = 0.200,
95% CI: 0.046–0.877, p-value = 0.033). KT is an aggressive tumor with a median OS of less than a year. Chemotherapy
may improve survival. Patients with a primary tumor in the colorectal region have
a better outcome, while those presenting with ascites indicate a poor prognosis.
Keywords
Krukenberg tumor - prognostic factors - survival - chemotherapy
