Abstract
Malformations of cortical development are rarely diagnosed in utero. Cortical malformations
are aberrations in the process of corticogenesis. We report two rare and unique cases
of evolving cortical malformation with unusual ultrasonogram markers: (1) narrow cavum
septum pellucidum and (2) ill-defined and irregular lateral ventricular borders on
the midtrimester anomaly scan. This was further confirmed by fetal brain evaluation
on magnetic resonance imaging with additional information on irregular ventricular
borders, scattered hyperintensities in the cerebral parenchyma and periventricular
area, loss of cerebral layering pattern at 24 weeks gestation in one case, and hemimegalencephaly
in another case with a probable diagnosis of evolving cortical malformation. Literature
review reveals the above as an unusual presentation on the anomaly scan.
Keywords
malformations of cortical development - narrow CSP - fetal MRI - irregular ventricular
margins - hemimegalencephaly
