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CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(05): E518-E523
DOI: 10.1055/s-0044-102297
Original article
Owner and Copyright © Georg Thieme Verlag KG 2018

Narrow band imaging efficiency in evaluation of mucosal healing/relapse of ulcerative colitis

Seiko Sasanuma
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Kazuo Ohtsuka
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
2   Department of Endoscopy, Tokyo Medical and Dental University, Tokyo, Japan
,
Shin-ei Kudo
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Noriyuki Ogata
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Yasuharu Maeda
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Masashi Misawa
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Yuichi Mori
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Toyoki Kudo
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Tomokauzu Hisayuki
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Kunihiko Wakamura
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Takemasa Hayashi
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Atsushi Katagiri
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Hideyuki Miyachi
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Toshiyuki Baba
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
,
Fumio Ishida
1   Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
› Author Affiliations
Further Information

Publication History

submitted 18 September 2017

accepted after revision 10 January 2018

Publication Date:
18 April 2018 (online)

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Abstract

Background and study aims Mucosal healing is a current treatment target in ulcerative colitis (UC), while histological remission is another target. The aim of this study was to evaluate the efficiency of magnified narrow band imaging (NBI) findings of mucosal healing and their relationship with histological activity and prognosis.

Patients and methods Patients with UC who underwent total colonoscopy between January 2010 and December 2012 with left-sided or total-colitis type UC and achieved clinical remission with an endoscopic Mayo score of 0 or 1 were included. Each colon section was observed with white light and magnified NBI, with the colonoscopy being repeated at 1-year follow-up. We assessed the relationships of magnified NBI with histological disease activity and prognosis. Magnified NBI findings were divided into three categories; honeycomb-like blood vessels (BV-H), blood vessels shaped like bare branches (BV-BB), and blood vessels shaped like vines (BV-V).

Results Fifty-two patients were included. The percentage of remitted mucosa with BV-BB was 37 %, while that of mucosa with scars with BV-H was 35 %. BV-H and BV-BB did not show pathological activity (12/292 and 8/299, respectively), while BV-V showed high pathological activity (27/33, 81 %). There was a correlation between magnified NBI findings and pathological findings (P < 0.01). The odds ratio for inflammation activity at 1-year follow-up was 14.2 for BV-BB (95 % CI, 3.3 – 60.9)

Conclusion Magnified NBI findings showed a good relationship with histological activity. This suggests that we could estimate histological activity without biopsy, and also the possibility of predicting relapse over the following year.

 

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