CC BY 4.0 · Libyan International Medical University Journal 2024; 09(01): 035-041
DOI: 10.1055/s-0044-1779669
Original Article

Quantitative Measurement and Analysis of the Radial Peripapillary and Central Macular Microvasculature Density in Early Open-Angle Glaucoma Using OCT Angiography

1   Department of Ophthalmology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Suliman Mohamed Masoud
1   Department of Ophthalmology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
2   Department of Ophthalmology, Benghazi Eye Hospital, Benghazi, Libya
› Author Affiliations
Funding None.


Abstract

Background Glaucoma is a prevalent cause of visual impairment, and early detection is critical to prevent progressive vision loss. Optical coherence tomography angiography (OCT-A) enables visualization of retinal and optic nerve microvasculature and holds promise for early glaucoma detection.

Aims This study aims to assess microvasculature density alterations in glaucoma using OCT-A.

Methods An observational cross-sectional case–control study was conducted at Benghazi Eye Hospital in Libya from December 2022 to August 2023. It included 160 eyes of 126 patients diagnosed with primary open-angle glaucoma and 120 eyes of 96 control subjects. OCT-A was performed using the Swept-Source OCT DRI Triton. Vessel density measurements were obtained from OCT-A images using new built-in software within the device. The data presented as mean ± standard deviation and percentages were analyzed using SPSS. The statistical significance of the differences between different groups was determined using independent t-tests, and the level of significance was set at p-value less than 0.05.

Results OCT-A demonstrated significantly reduced microvasculature density in glaucoma eyes across all optic nerve sectors including the inferior (29.0%), superior (25.2%), central (23.5%), nasal (9.9%), and temporal sectors (9.3%; p < 0.02). Moreover, glaucoma patients exhibited a significant reduction in vessel density in the superior macula (17% reduction), the temporal (15.7%,), nasal (12.9%), and inferior sectors (12.6%) (p < 0.002). No statistical difference was seen with vessel density of the central sector (0.49%, p >0.05).

Conclusion OCT-A demonstrated significant reductions in microvasculature density in glaucoma patients compared with healthy controls. These findings support the association between glaucoma and vascular changes. Additionally, the TOPCON Swept-Source OCT DRI Triton new software shows promise as a valuable tool for early detection and monitoring of glaucoma-related vascular changes.



Publication History

Article published online:
01 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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