Subscribe to RSS
DOI: 10.1055/s-0044-1779751
FDG-PET in HIV-Positive Patient with Extranodal Diffuse Large B-Cell Lymphoma
Abstract
Extranodal diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease process and an aggressive form of non-Hodgkin's lymphoma. We present a case of multiorgan involvement of DLBCL in a patient with documented risk factors, including [18F] fluorodeoxyglucose positron emission tomography/magnetic resonance imaging findings highlighting striking perineural spread involving intracranial and extracranial segments of the bilateral trigeminal nerves.
Keywords
extranodal lymphoma - diffuse large B-cell lymphoma - perineural spread - PET/MRI - brain PETAuthors' Contributions
F.M. and G.K. were involved in writing (original draft) and review and editing. J.E.G. helped in conceptualization, data curation, resources, and writing (review and editing). A.M.F. contributed to conceptualization, data curation, resources, software, supervision, writing (original draft), and review and editing.
Publication History
Article published online:
25 April 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Sehn LH, Salles G. Diffuse large B-cell lymphoma. N Engl J Med 2021; 384 (09) 842-858
- 2 Ollila TA, Olszewski AJ. Extranodal diffuse large B cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol 2018; 19 (08) 38
- 3 Villa D, Connors JM, Sehn LH, Gascoyne RD, Savage KJ. Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse. Haematologica 2011; 96 (07) 1002-1007
- 4 Lehners N, Krämer I, Schwarzbich MA, Ho AD, Witzens-Harig M. Analysis of clinical characteristics and outcome of patients with previously untreated diffuse large B-cell lymphoma and renal involvement in the rituximab era. Leuk Lymphoma 2016; 57 (11) 2619-2625
- 5 Ferreri AJM. Risk of CNS dissemination in extranodal lymphomas. Lancet Oncol 2014; 15 (04) e159-e169
- 6 Schmitz N, Zeynalova S, Nickelsen M. et al. CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 2016; 34 (26) 3150-3156
- 7 Møller MB, Pedersen NT, Christensen BE. Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation–a population-based study of 1575 cases. Br J Haematol 2004; 124 (02) 151-159
- 8 Boussios S, Zerdes I, Vassou A. et al. Extranodal diffuse large B-cell lymphomas: a retrospective case series and review of the literature. Hematol Rep 2018; 10 (01) 7070
- 9 Barta SK, Xue X, Wang D. et al. Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: a pooled analysis of 1546 patients. Blood 2013; 122 (19) 3251-3262
- 10 Besson C, Lancar R, Prevot S. et al; ANRS-CO16 LYMPHOVIR Cohort. Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era. AIDS 2017; 31 (18) 2493-2501
- 11 Cronin CG, Swords R, Truong MT. et al. Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol 2010; 194 (01) W91-W103
- 12 Sarikaya I. Biology of cancer and PET imaging: pictorial review. J Nucl Med Technol 2022; DOI: 10.2967/jnmt.121.263534.
- 13 Smith AB, Smirniotopoulos JG, Rushing EJ. From the archives of the AFIP: central nervous system infections associated with human immunodeficiency virus infection: radiologic-pathologic correlation. Radiographics 2008; 28 (07) 2033-2058
- 14 Tanwar M, Branstetter Iv BF. Mimics of perineural tumor spread in the head and neck. Br J Radiol 2021; 94 (1128): 20210099
- 15 Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN. Central nervous system lymphoma presenting as trigeminal neuralgia: a diagnostic challenge. J Clin Neurosci 2015; 22 (07) 1188-1190
- 16 Yılmaz S, Sağer S, Sen F, Halac M. Bilateral trigeminal nerve recurrence of non-Hodgkin lymphoma revealed with FDG PET/CT. Indian J Nucl Med 2014; 29 (01) 50-52