Abstract
Introduction This article describes an unusual case of perianal Paget's Disease in a 42-year-old
man, highlighting distinct characteristics about more typical cases.
Case report 42-year-old male patient with persistent perianal lesion, recurrent abscesses, and
discomfort. Magnetic resonance imaging indicated a possible fistulous path. Biopsy
revealed secondary anal Paget's disease and adenocarcinoma. Chemotherapy and radiotherapy
treatment demonstrated a positive response.
Discussion Perianal Paget's Disease is a rare condition of the anal canal that is part of the
Extramammary Paget's Disease (EMPD) group. Symptoms include itching, pain, perianal
bleeding, and skin lesions. Diagnosis can be challenging and usually involves performing
a histopathological biopsy associated with an immunohistochemical study. Treatment
varies and may involve surgery, radiotherapy, and chemotherapy. Due to the rarity
of the disease, the best therapeutic approach is not yet well defined, and follow-up
is essential due to the risk of recurrence.
Conclusion Perianal Paget's Disease is rare and requires differentiation from other conditions.
Early detection is essential to prevent malignancy.
Keywords
Extramammary Paget's Disease - rectal fistula - Diseases of the Anus - anal channel
