CC BY 4.0 · ACI open 2024; 08(01): e25-e32
DOI: 10.1055/s-0044-1782534
Research Article

Factors Influencing Health Care Professionals' Perceptions of Frequent Drug–Drug Interaction Alerts

Yasmine Biady
1   School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia
Teresa Lee
1   School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia
Lily Pham
1   School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia
Asad Patanwala
1   School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia
2   Department of Pharmacy, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Simon Poon
3   School of Computer Science, Faculty of Engineering, The University of Sydney, New South Wales, Australia
Angus Ritchie
4   Department of Nephrology, Concord Repatriation General Hospital, Sydney, New South Wales, Australia
Rosemary Burke
5   Department of Pharmacy, Sydney Local Health District, Sydney, New South Wales, Australia
Jonathan Penm
1   School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia
6   Department of Pharmacy, Prince of Wales Hospital, Randwick, Australia
› Institutsangaben
Funding No funding was received.


Background Drug–drug interactions (DDIs) remain a highly prevalent issue for patients in both community and hospital settings. Electronic medication management systems have implemented DDI alerts to mitigate DDI-related harm from occurring.

Objectives The primary aim of this study was to explore factors that influence health care professionals' (hospital doctors, hospital pharmacists, general practitioners, and community pharmacists) perceptions and action taken by them in response to DDI alerts.

Methods A qualitative study was conducted using semi-structured interviews between early January and late February 2021. The top 20 most frequently triggered DDI alerts previously identified were used as examples of alert prompts shown to participants.

Results A total of 20 participants were recruited. General practitioners (n = 4) were most likely to consider DDI alerts to be clinically relevant and important, and hospital doctors (n = 4) were most likely to consider these alerts not being clinically relevant nor important. Three main factors were identified to influence health care professionals' perceptions of DDI alerts, which included clinical relevance, visual presentation, and content of alerts.

Conclusion Health care professionals' perceptions of DDI alerts are influenced by multiple factors and considerations are required to create tailored alerts for users and their clinical contexts. Improvement in DDI alerts should be a priority to improve patient medication safety and health outcomes.

Protection of Human and Animal Subjects

This study was conducted at the Royal Prince Alfred Hospital as authorized by Sydney Local Health District (protocol number: X20-0533).

Supplementary Material


Eingereicht: 16. März 2023

Angenommen: 26. Januar 2024

Artikel online veröffentlicht:
31. März 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

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