CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0044-1787291
Original Article

Oncological Safety and Feasibility of Posterior Marginal Mandibulectomy vis-à-vis Anterior Marginal Mandibulectomy in Oral Cancers

Sudhir Nair
1   Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Affiliated to the Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India
,
Hitesh R. Singhavi
2   Department of Surgical Oncology, Fortis Hospital Mulund, Mumbai, Maharashtra, India
,
3   Command Hospital (WC), Chandimandir, Haryana, India
,
Rathan Shetty
1   Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Affiliated to the Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India
,
Poonam Joshi
1   Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Affiliated to the Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India
,
4   Department of Radiation Oncology, Tata Memorial Hospital, Affiliated to the Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Pankaj Chaturvedi
5   Department of Surgical Oncology, Tata Memorial Hospital, Affiliated to the Homi Bhabha National Institute, Mumbai, Maharashtra, India
› Author Affiliations
Funding None.

Abstract

Zoom Image
Sudhir Nair

The surgical management of retromolar trigone cancer (RTC) is an area of contention regarding the extent of bony resection. We aim to evaluate the oncological safety and feasibility of posterior marginal mandibulectomy (PMM) for RTC. We analyzed the clinical records of 98 patients with squamous cell carcinoma managed surgically using marginal mandibulectomy during 2014 to 2017, in which anterior segment mandibulectomy (AMM) and PMM were done in 56 and 42 patients, respectively. The median follow-up time was 44.4 months (95% confidence interval [CI] 42.3, 49.5) and the overall survival rate was 93.9% (95% CI 89.4–98.8%). The local recurrence rate was 19.6 and 18.3 % in PMM and AMM (p = 0.854). In the PMM group, osteoradionecrosis (ORN) was detected in two patients (4.3%) and fractures in one (2.1%) patient, while the AMM group neither had fracture nor ORN till the latest follow-up. The study results suggest that PMM is an oncological safe and adequate procedure for RTC.



Publication History

Received: 21 June 2023

Accepted: 01 May 2024

Article published online:
30 May 2024

© 2024. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Werning JW, Abrahams JJ, Amdur R. et al. Oral Cancer: Diagnosis, Management, and Rehabilitation. Thieme Verlag; 2007
  • 2 Mazziotti S, Pandolfo I, D'Angelo T. et al. Diagnostic approach to retromolar trigone cancer by multiplanar computed tomography reconstructions. Can Assoc Radiol J 2014; 65 (04) 335-344
  • 3 Petruzzelli GJ, Knight FK, Vandevender D, Clark JI, Emami B. Posterior marginal mandibulectomy in the management of cancer of the oral cavity and oropharynx. Otolaryngol Head Neck Surg 2003; 129 (06) 713-719
  • 4 Pinsolle V, Truilhé Y, Majoufre C, Michelet V, Pinsolle J. Posterior marginal mandibulectomy for cancer of the oral cavity and oropharynx. Experience with 14 clinical cases [in French]. Ann Chir Plast Esthet 1997; 42 (03) 223-227
  • 5 Wong RCW, Tideman H, Kin L, Merkx MA. Biomechanics of mandibular reconstruction: a review. Int J Oral Maxillofac Implants 2010; 39 (04) 313-319
  • 6 Ayad T, Guertin L, Soulières D, Belair M, Temam S, Nguyen-Tân PF. Controversies in the management of retromolar trigone carcinoma. Head Neck 2009; 31 (03) 398-405
  • 7 Petrovic I, Montero PH, Migliacci JC. et al. Influence of bone invasion on outcomes after marginal mandibulectomy in squamous cell carcinoma of the oral cavity. J Craniomaxillofac Surg 2017; 45 (02) 252-257
  • 8 Pathak KA, Shah BC. Marginal mandibulectomy: 11 years of institutional experience. J Oral Maxillofac Surg 2009; 67 (05) 962-967
  • 9 Demir UL, Öztürk Yanaşma H. Treatment outcomes for primary retromolar trigone carcinoma: a single institution experience. Turk Arch Otorhinolaryngol 2020; 58 (02) 87-92
  • 10 Nabil S, Samman N. Risk factors for osteoradionecrosis after head and neck radiation: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113 (01) 54-69
  • 11 Faisal M, Abbas T, Khaleeq U. et al. Treatment outcomes of rare retromolar trigone squamous cell carcinoma using combined modalities. Cureus 2017; 9 (05) e1203
  • 12 Du W, Fang Q, Wu Y, Wu J, Zhang X. Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva. BMC Cancer 2019; 19 (01) 775
  • 13 Chen Y-L, Kuo S-W, Fang K-H, Hao S-P. Prognostic impact of marginal mandibulectomy in the presence of superficial bone invasion and the nononcologic outcome. Head Neck 2011; 33 (05) 708-713
  • 14 Gou L, Yang W, Qiao X. et al. Marginal or segmental mandibulectomy: treatment modality selection for oral cancer: a systematic review and meta-analysis. Int J Oral Maxillofac Implants 2018; 47 (01) 1-10